Search Results - "Barkauskas, Deborah"

Co-inhibition of CD73 and A2AR Adenosine Signaling Improves Anti-tumor Immune Responses by Young, Arabella, Ngiow, Shin Foong, Barkauskas, Deborah S., Sult, Erin, Hay, Carl, Blake, Stephen J., Huang, Qihui, Liu, Jing, Takeda, Kazuyoshi, Teng, Michele W.L., Sachsenmeier, Kris, Smyth, Mark J.

“…Preclinical studies targeting the adenosinergic pathway have gained much attention for their clinical potential in overcoming tumor-induced immunosuppression…”
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A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment by Young, Arabella, Ngiow, Shin Foong, Gao, Yulong, Patch, Ann-Marie, Barkauskas, Deborah S, Messaoudene, Meriem, Lin, Gene, Coudert, Jerome D, Stannard, Kimberley A, Zitvogel, Laurence, Degli-Esposti, Mariapia A, Vivier, Eric, Waddell, Nicola, Linden, Joel, Huntington, Nicholas D, Souza-Fonseca-Guimaraes, Fernando, Smyth, Mark J

“…Extracellular adenosine is a key immunosuppressive metabolite that restricts activation of cytotoxic lymphocytes and impairs antitumor immune responses. Here,…”
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Cdk5 disruption attenuates tumor PD-L1 expression and promotes antitumor immunity by Dorand, R. Dixon, Nthale, Joseph, Myers, Jay T., Barkauskas, Deborah S., Avril, Stefanie, Chirieleison, Steven M., Pareek, Tej K., Abbott, Derek W., Stearns, Duncan S., Letterio, John J., Huang, Alex Y., Petrosiute, Agne

“…Cancers often evade immune surveillance by adopting peripheral tissue–tolerance mechanisms, such as the expression of programmed cell death ligand 1 (PD-L1),…”
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Noninvasive in vivo human multiphoton microscopy: a key method in proving nanoparticulate zinc oxide sunscreen safety by Mohammed, Yousuf H, Barkauskas, Deborah S, Holmes, Amy, Grice, Jeffrey, Roberts, Michael S

“…We describe the contribution of our in vivo multiphoton microscopy (MPM) studies over the last ten years with DermaInspect® (JenLab, Germany), a CE-certified…”
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Adenosine 2B Receptor Expression on Cancer Cells Promotes Metastasis by Mittal, Deepak, Sinha, Debottam, Barkauskas, Deborah, Young, Arabella, Kalimutho, Murugan, Stannard, Kimberley, Caramia, Franco, Haibe-Kains, Benjamin, Stagg, John, Khanna, Kum Kum, Loi, Sherene, Smyth, Mark J

“…Adenosine plays an important role in inflammation and tumor development, progression, and responses to therapy. We show that an adenosine 2B receptor inhibitor…”
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High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieback in traumatic spinal cord injury by Evans, Teresa A., Barkauskas, Deborah S., Myers, Jay T., Hare, Elisabeth G., You, Jing Qiang, Ransohoff, Richard M., Huang, Alex Y., Silver, Jerry

“…After traumatic spinal cord injury, functional deficits increase as axons die back from the center of the lesion and the glial scar forms. Axonal dieback…”
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Intravital imaging of immune cells and their interactions with other cell types in the spinal cord: Experiments with multicolored moving cells by Evans, Teresa A., Barkauskas, Deborah S., Silver, Jerry

“…Intravital imaging of the immune system is a powerful technique for studying biology of the immune response in the spinal cord using a variety of disease…”
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NK cell heparanase controls tumor invasion and immune surveillance by Putz, Eva M, Mayfosh, Alyce J, Kos, Kevin, Barkauskas, Deborah S, Nakamura, Kyohei, Town, Liam, Goodall, Katharine J, Yee, Dean Y, Poon, Ivan Kh, Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D, Smyth, Mark J

“…NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly…”
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Targeting Adenosine in BRAF-Mutant Melanoma Reduces Tumor Growth and Metastasis by Young, Arabella, Ngiow, Shin Foong, Madore, Jason, Reinhardt, Julia, Landsberg, Jennifer, Chitsazan, Arash, Rautela, Jai, Bald, Tobias, Barkauskas, Deborah S, Ahern, Elizabeth, Huntington, Nicholas D, Schadendorf, Dirk, Long, Georgina V, Boyle, Glen M, Hölzel, Michael, Scolyer, Richard A, Smyth, Mark J

“…Increasing evidence exists for the role of immunosuppressive adenosine in promoting tumor growth and spread in a number of cancer types, resulting in poor…”
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The roles of blood-derived macrophages and resident microglia in the neuroinflammatory response to implanted Intracortical microelectrodes by Ravikumar, Madhumitha, Sunil, Smrithi, Black, James, Barkauskas, Deborah S, Haung, Alex Y, Miller, Robert H, Selkirk, Stephen M, Capadona, Jeffrey R

“…Abstract Resident microglia and blood-borne macrophages have both been implicated to play a dominant role in mediating the neuroinflammatory response affecting…”
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Co-administration of RANKL and CTLA4 Antibodies Enhances Lymphocyte-Mediated Antitumor Immunity in Mice by Ahern, Elizabeth, Harjunpää, Heidi, Barkauskas, Deborah, Allen, Stacey, Takeda, Kazuyoshi, Yagita, Hideo, Wyld, David, Dougall, William C, Teng, Michele W L, Smyth, Mark J

“…Novel partners for established immune checkpoint inhibitors in the treatment of cancer are needed to address the problems of primary and acquired resistance…”
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NK cell heparanase controls tumor invasion and immune surveillance by Putz, Eva M, Mayfosh, Alyce J, Kos, Kevin, Barkauskas, Deborah S, Nakamura, Kyohei, Town, Liam, Goodall, Katharine J, Yee, Dean Y, Poon, Ivan Kh, Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D, Smyth, Mark J

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CCL3 augments tumor rejection and enhances CD8+ T cell infiltration through NK and CD103+ dendritic cell recruitment via IFNγ by Allen, Frederick, Bobanga, Iuliana D., Rauhe, Peter, Barkauskas, Deborah, Teich, Nathan, Tong, Caryn, Myers, Jay, Huang, Alex Y.

“…Inflammatory chemokines are critical contributors in attracting relevant immune cells to the tumor microenvironment and driving cellular interactions and…”
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SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation by Adolphe, Christelle, Millar, Amanda, Kojic, Marija, Barkauskas, Deborah S, Sundström, Anders, Swartling, Fredrik J, Hediyeh-Zadeh, Soroor, Tan, Chin Wee, Davis, Melissa J, Genovesi, Laura A, Wainwright, Brandon J

“…Medulloblastoma is the most common malignant pediatric brain tumor and there is an urgent need for molecularly targeted and subgroup-specific therapies. The…”
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Proximity Labelling Confirms the Involvement of Papain-Like Cysteine Proteases and Chaperones in Cyclotide Biosynthesis by Lee, Meng-Han, Jackson, Mark A., Rehm, Fabian B. H., Barkauskas, Deborah S., Ho, Wing L., Yap, Kuok, Craik, David J., Gilding, Edward K.

“…Cyclotides are disulfide-rich insecticidal peptides from plants that harbour a cyclic cystine knot motif that imparts them with high stability. Like most…”
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CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms by Li, Xian-Yang, Das, Indrajit, Lepletier, Ailin, Addala, Venkateswar, Bald, Tobias, Stannard, Kimberley, Barkauskas, Deborah, Liu, Jing, Aguilera, Amelia Roman, Takeda, Kazuyoshi, Braun, Matthias, Nakamura, Kyohei, Jacquelin, Sebastien, Lane, Steven W, Teng, Michele Wl, Dougall, William C, Smyth, Mark J

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Selective activation of anti-CD73 mechanisms in control of primary tumors and metastases by Vijayan, Dipti, Barkauskas, Deborah S., Stannard, Kimberley, Sult, Erin, Buonpane, Rebecca, Takeda, Kazuyoshi, Teng, Michele W. L., Sachsenmeier, Kris, Hay, Carl, Smyth, Mark J.

“…The emerging role for CD73 in driving cancer growth and metastasis has presented opportunities to develop anti-CD73 monoclonal antibodies (mAbs) in the…”
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Co-inhibition of colony stimulating factor-1 receptor and BRAF oncogene in mouse models of BRAFV600E melanoma by Ngiow, Shin Foong, Meeth, Katrina M., Stannard, Kimberley, Barkauskas, Deborah S., Bollag, Gideon, Bosenberg, Marcus, Smyth, Mark J.

“…The presence of colony stimulating factor-1 (CSF1)/CSF1 receptor (CSF1R)-driven tumor-infiltrating macrophages and myeloid-derived suppressor cells (MDSCs) is…”
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Focal transient CNS vessel leak provides a tissue niche for sequential immune cell accumulation during the asymptomatic phase of EAE induction by Barkauskas, Deborah S., Dixon Dorand, R., Myers, Jay T., Evans, Teresa A., Barkauskas, Kestutis J., Askew, David, Purgert, Robert, Huang, Alex Y.

“…Peripheral immune cells are critical to the pathogenesis of neurodegenerative diseases including multiple sclerosis (MS) (Hendriks et al., 2005; Kasper and…”
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Transient Surface CCR5 Expression by Naive CD8+ T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell-Dependent Memory Response by Askew, David, Su, Charles A, Barkauskas, Deborah S, Dorand, R Dixon, Myers, Jay, Liou, Rachel, Nthale, Joseph, Huang, Alex Y

“…In inflamed lymph nodes, Ag-specific CD4(+) and CD8(+) T cells encounter Ag-bearing dendritic cells and, together, this complex enhances the release of CCL3…”
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