Search Results - "Barkan, Daniel"

Establishment and Validation of Galleria mellonella as a Novel Model Organism To Study Mycobacterium abscessus Infection, Pathogenesis, and Treatment by Meir, Michal, Grosfeld, Tatyana, Barkan, Daniel

“…Treatment of infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of…”
Get full text

Alternative and Experimental Therapies of Mycobacterium abscessus Infections by Meir, Michal, Barkan, Daniel

“…is a non-tuberculous mycobacterium notoriously known for causing severe, chronic infections. Treatment of these infections is challenging due to either…”
Get full text

Virulence-Associated Secretion in Mycobacterium abscessus by Bar-Oz, Michal, Meir, Michal, Barkan, Daniel

“…Non-tuberculous mycobacteria (NTM) are a heterogeneous group of originally environmental organi3sms, increasingly recognized as pathogens with rising…”
Get full text

The Mycobacterium abscessus mbtE Analog MAB_2122 Is, in Contrast to the mbtE Analog MAB_2248c, Dispensable for Normal Growth in Low-Iron Conditions by Foreman, Mark, Barkan, Daniel

Get full text

The small non-coding RNA B11 regulates multiple facets of Mycobacterium abscessus virulence by Bar-Oz, Michal, Martini, Maria Carla, Alonso, Maria Natalia, Meir, Michal, Lore, Nicola Ivan, Miotto, Paolo, Riva, Camilla, Angala, Shiva K, Xiao, Junpei, Masiello, Catherine S, Misiakou, Maria-Anna, Sun, Huaming, Moy, Justin K, Jackson, Mary, Johansen, Helle Krogh, Cirillo, Daniela Maria, Shell, Scarlet S, Barkan, Daniel

“…Mycobacterium abscessus causes severe disease in patients with cystic fibrosis. Little is known in M. abscessus about the roles of small regulatory RNAs (sRNA)…”
Get full text

Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis by Watson, Avia, Li, Hao, Ma, Bingting, Weiss, Ronen, Bendayan, Daniele, Abramovitz, Lilach, Ben-Shalom, Noam, Mor, Michael, Pinko, Erica, Bar Oz, Michal, Wang, Zhenqi, Du, Fengjiao, Lu, Yu, Rybniker, Jan, Dahan, Rony, Huang, Hairong, Barkan, Daniel, Xiang, Ye, Javid, Babak, Freund, Natalia T.

“…Mycobacterium tuberculosis (Mtb) exposure drives antibody responses, but whether patients with active tuberculosis elicit protective antibodies, and against…”
Get full text

Peptide Deformylase (def) is essential in Mycobacterium smegmatis, but the essentiality is compensated by inactivation of methionine formylation by Naor, Noga, Gadot, Omer, Meir, Michal, Barkan, Daniel

“…Co-translational processes in bacteria are attractive drug targets, but while some processes are essential, others are not. The essentiality of Peptide…”
Get full text

A Pivotal Role for Mycobactin/ mbtE in Growth and Adaptation of Mycobacterium abscessus by Foreman, Mark, Kolodkin-Gal, Ilana, Barkan, Daniel

“…Mycobacterium abscessus is an emerging pathogen that critically depends on iron for growth and pathogenesis. The acquisition of iron in Mycobacterium…”
Get full text

Differential Sensitivity of Mycobacteria to Isoniazid Is Related to Differences in KatG-Mediated Enzymatic Activation of the Drug by Reingewertz, Tali H, Meyer, Tom, McIntosh, Fiona, Sullivan, Jaryd, Meir, Michal, Chang, Yung-Fu, Behr, Marcel A, Barkan, Daniel

“…Isoniazid (INH) is a cornerstone of antitubercular therapy. complex bacteria are the only mycobacteria sensitive to clinically relevant concentrations of INH…”
Get full text

EttA is likely non-essential in Staphylococcus aureus persistence, fitness or resistance to antibiotics by Meir, Michal, Rozenblit, Anna, Fliger, Simona, Geffen, Yuval, Barkan, Daniel

“…Tolerance to antibiotics and persistence are associated with antibiotic treatment failures, chronic-relapsing infections, and emerging antibiotic resistance in…”
Get full text

The Nocardial aph(2″) Gene Confers Tobramycin and Gentamicin Resistance and Is an Effective Positive Selection Marker in Mycobacteria and Nocardia by Hershko, Yizhak, Adler, Amos, Barkan, Daniel

“…The current study aimed to evaluate the feasibility of using the aminoglycoside 2″-O-phosphotransferase gene as a positive selection marker in , , and . The…”
Get full text

A Simplified and Efficient Method for Himar-1 Transposon Sequencing in Bacteria, Demonstrated by Creation and Analysis of a Saturated Transposon-Mutant Library in Mycobacterium abscessus by Foreman, Mark, Gershoni, Moran, Barkan, Daniel

“…Transposon insertion sequencing is a powerful tool, but many researchers are discouraged by the apparent technical complexity of preparing the genomic library…”
Get full text

Mycobacterium tuberculosis Lacking All Mycolic Acid Cyclopropanation Is Viable but Highly Attenuated and Hyperinflammatory in Mice by BARKAN, Daniel, HEDHLI, Dorsaf, YAN, Han-Guang, HUYGEN, Kris, GLICKMANA, Michael S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

The addition of avibactam renders piperacillin an effective treatment for Mycobacterium abscessus infection in an in vivo model by Meir, Michal, Bifani, Pablo, Barkan, Daniel

“…Treating infection is challenging due to the potent β-lactamase Bla (Beta-lactamase of . Avibactam is a non-β-lactam, β-lactamase inhibitor shown to inhibit…”
Get full text

Comparison of Isogenic Strains Shows No Evidence of Altered Nosocomial Transmission-Competency of Rough, GPL-Negative Mycobacterium abscessus Strains by Meir, Michal, Foreman, Mark, Bar-Oz, Michal, Naor, Noga, Rozenblit, Anna, Barkan, Daniel

“…Mycobacterium abscessus is an emerging pathogen causing severe pulmonary infections. While environmental in origin, in the clinical setting M. abscessus often…”
Get full text

Redundant Function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis Cyclopropanation of Oxygenated Mycolates by BARKAN, Daniel, RAO, Vivek, SUKENICK, George D, GLICKMAN, Michael S

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR , but Not by L-, D- or Iso-Glutamine by Rakovitsky, Nadya, Bar Oz, Michal, Goldberg, Karin, Gibbons, Simon, Zimhony, Oren, Barkan, Daniel

“…Nitrogen metabolism plays a central role in the physiology of microorganisms, and Glutamine Synthetase (GS) genes are present in virtually all bacteria. In ,…”
Get full text

Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses by Velasquez, Lis Noelia, Stüve, Philipp, Gentilini, Maria Virginia, Swallow, Maxine, Bartel, Judith, Lycke, Nils Yngve, Barkan, Daniel, Martina, Mariana, Lujan, Hugo D, Kalay, Hakan, van Kooyk, Yvette, Sparwasser, Tim D, Berod, Luciana

“…Tuberculosis remains a major global health problem and efforts to develop a more effective vaccine have been unsuccessful so far. Targeting antigens (Ags) to…”
Get full text

M.tuberculosis mutants lacking oxygenated mycolates show increased immunogenicity and protective efficacy as compared to M. bovis BCG vaccine in an experimental mouse model by Hedhli, Dorsaf, Denis, Olivier, Barkan, Daniel, Daffé, Mamadou, Glickman, Michael S, Huygen, Kris

“…The existing vaccine against tuberculosis (M. bovis BCG) exerts some protection against the extrapulmonary forms of the disease, particularly in young…”
Get full text

MapB Protein is the Essential Methionine Aminopeptidase in Mycobacterium tuberculosis by Vanunu, Miriam, Schall, Patrick, Reingewertz, Tali-Haviv, Chakraborti, Pradip K, Grimm, Bernhard, Barkan, Daniel

“…, which causes tuberculosis disease, continues to be a major global health threat. Correct identification of valid drug targets is important for the…”
Get full text