Search Results - "Barkan, A L"

Role of pulsatile growth hormone (GH) secretion in the regulation of lipolysis in fasting humans by Goldenberg, N, Horowitz, J F, Gorgey, A, Sakharova, A, Barkan, A L

“…The increase in growth hormone (GH) secretion during a prolonged fast stimulates lipolytic rate, thereby augmenting the mobilization of endogenous energy at a…”
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Evaluation of the integrity of the hypothalamic-pituitary-adrenal axis by insulin hypoglycemia test by ERTURK, E, JAFFE, C. A, BARKAN, A. L

“…We retrospectively reviewed dynamic ACTH and cortisol responses to insulin hypoglycemia in 193 subjects with suspected ACTH deficiency to ascertain the…”
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In vivo semiquantification of hypothalamic growth hormone-releasing hormone (GHRH) output in humans : Evidence for relative GHRH deficiency in aging by RUSSELL-AULET, M, JAFFE, C. A, DEMOTT-FRIBERG, R, BARKAN, A. L

“…GH secretion declines with aging. The neuroendocrine mechanisms of somatopause are uncertain. To semiquantify endogenous hypothalamic GHRH output, we measured…”
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Regulatory mechanisms of growth hormone secretion are sexually dimorphic by Jaffe, C A, Ocampo-Lim, B, Guo, W, Krueger, K, Sugahara, I, DeMott-Friberg, R, Bermann, M, Barkan, A L

“…Sexually dimorphic growth hormone (GH) secretory pattern is important in the determination of gender-specific patterns of growth and metabolism in rats…”
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Pituitary irradiation is ineffective in normalizing plasma insulin-like growth factor I in patients with acromegaly by Barkan, A L, Halasz, I, Dornfeld, K J, Jaffe, C A, Friberg, R D, Chandler, W F, Sandler, H M

“…Pituitary irradiation suppresses GH hypersecretion in patients with acromegaly. Within 10 yr after radiotherapy, up to 80% of patients achieve plasma GH levels…”
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Pituitary disorders : Drug treatment options by ORREGO, J. J, BARKAN, A. L

“…Pituitary diseases are relatively common entities in the general population. They include pituitary adenomas and hypopituitarism. Pituitary tumours can cause…”
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The quality of life-assessment of growth hormone deficiency in adults questionnaire : Can it be used to assess quality of life in hypopituitarism by BARKAN, Ariel L

“…Patients with hypopituitarism often have a multitude of physical and psychological complaints, collectively referred to as low quality of life (QoL). It has…”
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Chromosome 13q deletion mapping in pituitary tumors : Infrequent loss of the retinoblastoma susceptibility gene (RB1) locus despite loss of RB1 protein product in somatotrophinomas by SIMPSON, D. J, MAGNAY, J, BICKNELL, J. E, BARKAN, A. L, MCNICOL, A. M, CLAYTON, R. N, FARRELL, W. E

“…Two recent studies have described allelic loss of an RB1 intragenic marker on chromosome 13q in aggressive and metastatic pituitary tumors that did not…”
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Growth hormone (GH)-releasing peptide-6 requires endogenous hypothalamic GH-releasing hormone for maximal GH stimulation by PANDYA, N, DEMOTT-FRIBERG, R, BOWERS, C. Y, BARKAN, A. L, JAFFE, C. A

“…GH-releasing peptide-6 (GHRP-6) is a potent GH secretagogue that releases GH by uncertain mechanisms. To assess whether GHRH is required for GH release by…”
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Suppression of growth hormone (GH) secretion by a selective GH-releasing hormone (GHRH) antagonist : direct evidence for involvement of endogenous GHRH in the generation of GH pulses by JAFFE, C. A, DEMOTT FRIBERG, R, BARKAN, A. L

“…To study the potential involvement of growth hormone-releasing hormone (GHRH) in the generation of growth hormone (GH) pulses in humans we have used a…”
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Aging-related growth hormone (GH) decrease is a selective hypothalamic GH-releasing hormone pulse amplitude mediated phenomenon by Russell-Aulet, M, Dimaraki, E V, Jaffe, C A, DeMott-Friberg, R, Barkan, A L

“…Aging is accompanied by declining growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels. The neuroendocrine mechanisms of this decline have been…”
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Treatment of acromegaly with dopamine agonists by Jaffe, C A, Barkan, A L

“…This article reviews the current understanding of how dopamine agonists stimulate growth hormone secretion in normal individuals, yet suppress growth hormone…”
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Giant pituitary prolactinoma with falsely low serum prolactin: the pitfall of the "high-dose hook effect": case report by Barkan, A L, Chandler, W F

“…We present a case of a giant prolactinoma with a falsely low serum prolactin concentration determined by a two-site chemiluminometric assay. Awareness of the…”
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Negative feedback regulation of pulsatile growth hormone secretion by insulin-like growth factor I. Involvement of hypothalamic somatostatin by Bermann, M, Jaffe, C A, Tsai, W, DeMott-Friberg, R, Barkan, A L

“…To investigate the mechanisms of the negative feedback inhibition of growth hormone (GH) secretion by IGF-I, we studied parameters of GH pulsatility in six…”
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Acromegaly. Diagnosis and therapy by Barkan, A L

“…Acromegaly may be due to various pathologic processes, but the majority of patients harbor a GH-producing pituitary tumor. Careful clinical, biochemical, and…”
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Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist by van der Lely, Aart Jan, Hutson, R Kent, Trainer, Peter J, Besser, G Michael, Barkan, Ariel L, Katznelson, Laurence, Klibanski, Anne, Herman-Bonert, Vivien, Melmed, Shlomo, Vance, Mary Lee, Freda, Pamela U, Stewart, Paul M, Friend, Keith E, Clemmons, David R, Johannsson, Gudmundur, Stavrou, Stavros, Cook, David M, Phillips, Lawrence S, Strasburger, Christian J, Hacker, Suzanne, Zib, Kenneth A, Davis, Robert J, Scarlett, John A, Thorner, Michael O

“…Pegvisomant is a new growth hormone receptor antagonist that improves symptoms and normalises insulin-like growth factor-1 (IGF-1) in a high proportion of…”
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Plasma insulin-like growth factor-I/somatomedin-C in acromegaly: correlation with the degree of growth hormone hypersecretion by Barkan, A L, Beitins, I Z, Kelch, R P

“…We measured plasma insulin-like growth factor I/somatomedin-C (IGF-I/SmC) concentrations and mean 24-h GH secretion serially before and during therapy with the…”
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Nocturnal growth hormone (GH) secretion is eliminated by infusion of GH-releasing hormone antagonist by OCAMPO-LIM, B, GUO, W, DEMOTT-FRIBERG, R, BARKAN, A. L, JAFFE, C. A

“…The neuroendocrine mechanisms underlying the generation of pulsatile GH secretion in humans are poorly understood. GH secretory pulses are likely to result…”
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Effects of a prolonged growth hormone (GH)-releasing peptide infusion on pulsatile GH secretion in normal men by Jaffe, C A, Ho, P J, Demott-Friberg, R, Bowers, C Y, Barkan, A L

“…Bolus injection of the synthetic hexapeptide GH-releasing peptide-6 (GHRP-6) reliably promotes GH secretion. However, desensitization to the GH-releasing…”
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Rapid reduction of left ventricular hypertrophy in acromegaly after suppression of growth hormone hypersecretion by Lim, M J, Barkan, A L, Buda, A J

“…To examine the possible role of growth hormone as a pathogenetic factor in the development of myocardial hypertrophy in acromegaly. An uncontrolled clinical…”
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