Search Results - "Barkalow, Jufang"

Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor by Barnes, David M, Shekhar, Shashank, Dunn, Travis B, Barkalow, Jufang H, Chan, Vincent S, Franczyk, Thaddeus S, Haight, Anthony R, Hengeveld, John E, Kolaczkowski, Lawrence, Kotecki, Brian J, Liang, Guangxin, Marek, James C, McLaughlin, Maureen A, Montavon, Donna K, Napier, James J

“…Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the…”
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A Facile Method for the Preparation of MOM-Protected Carbamates by Barnes, David M, Barkalow, Jufang, Plata, Daniel J

“…A novel method for the preparation of MOM-protected carbamates is described that avoids the use of MOM-Cl, a regulated carcinogen. The two-step, one-pot…”
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Process Development for ABT-472, a Benzimidazole PARP Inhibitor by Barkalow, Jufang H, Breting, Jeffrey, Gaede, Bruce J, Haight, Anthony R, Henry, Rodger, Kotecki, Brian, Mei, Jianzhang, Pearl, Kurt B, Tedrow, Jason S, Viswanath, Shekhar K

“…A nine-step convergent process was developed for the synthesis of ABT-472, a benzimidazole PARP inhibitor. The identity and origin of several impurities were…”
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Synthesis of (R)‑Boc-2-methylproline via a Memory of Chirality Cyclization. Application to the Synthesis of Veliparib, a Poly(ADP-ribose) Polymerase Inhibitor by Kolaczkowski, Lawrence, Barkalow, Jufang, Barnes, David M, Haight, Anthony, Pritts, Wayne, Schellinger, Adam

“…(R)-Boc-2-methylproline (3a) was synthesized in good yield with excellent stereochemical control from alanine benzyl ester hydrochloride 11. The process, which…”
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Impact of Entropic Effects in the Classical Resolution of a 2-Arylpyrrolidine by Barnes, David M, Barkalow, Jufang, Chen, Yong, Gupta, Ashok, Haight, Anthony R, Hengeveld, John E, Kerdesky, Francis A. J, Kotecki, Brian J, Macri, Bryan, Pal, Agnes

“…The impact of entropic effects on the classical salt resolution of a 2-arylpyrrolidine is described. We have found that the crystallization of a racemic…”
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A Scalable Process for the Novel Antidepressant ABT-200 by Deshpande, Mahendra N, Cain, Michael H, Patel, Subhash R, Singam, Pulla Reddy, Brown, David, Gupta, Ashok, Barkalow, Jufang, Callen, Gary, Patel, Ketan, Koops, Roger, Chorghade, Mukund, Foote, Howard, Pariza, Richard

“…A scalable process for the novel antidepressant ABT-200, starting with 5,6-methylenedioxy-1-tetralone, is described. The new process improves the scale-up and…”
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