Search Results - "Barja, Gustavo"

Updating the mitochondrial free radical theory of aging: an integrated view, key aspects, and confounding concepts by Barja, Gustavo

“…An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity is reviewed. Key aspects of the theory are emphasized. Another main…”
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Towards a unified mechanistic theory of aging by Barja, Gustavo

“…A large amount of the longevity-modulating genes discovered during the last two decades are highly conserved during evolution from yeast and invertebrates to…”
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The Mitochondrial Free Radical Theory of Aging by Barja, Gustavo

“…The mitochondrial free radical theory of aging is reviewed. Only two parameters currently correlate with species longevity in the right sense: the…”
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Regulation of longevity and oxidative stress by nutritional interventions: Role of methionine restriction by Sanchez-Roman, Ines, Barja, Gustavo

“…Comparative studies indicate that long-lived mammals have low rates of mitochondrial reactive oxygen species production (mtROSp) and oxidative damage in their…”
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Mitochondrial oxidative stress, aging and caloric restriction: The protein and methionine connection by Pamplona, Reinald, Barja, Gustavo

“…Caloric restriction (CR) decreases aging rate and mitochondrial ROS (MitROS) production and oxidative stress in rat postmitotic tissues. Low levels of these…”
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Programmed versus non-programmed evolution of aging. What is the evidence? by Pamplona, Reinald, Jové, Mariona, Gómez, José, Barja, Gustavo

“…The evolutionary meaning and basic molecular mechanisms involved in the determination of longevity remain an unresolved problem. Currently, different theories…”
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Whole organism aging: Parabiosis, inflammaging, epigenetics, and peripheral and central aging clocks. The ARS of aging by Pamplona, Reinald, Jové, Mariona, Gómez, José, Barja, Gustavo

“…The strong interest shown in the study of the causes of aging in recent decades has uncovered many mechanisms that could contribute to the rate of aging. These…”
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Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production–DNA damage mechanism? by Barja, Gustavo

“…Oxygen is toxic to aerobic animals because it is univalently reduced inside cells to oxygen free radicals. Studies dealing with the relationship between…”
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Rate of generation of oxidative stress-related damage and animal longevity by Barja, Gustavo

“…Comparative studies about the relationship between endogenous antioxidant and pro-oxidant factors and maximum longevity of different animal species are…”
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Mitochondrial ROS production, oxidative stress and aging within and between species: Evidences and recent advances on this aging effector by Gómez, José, Mota-Martorell, Natàlia, Jové, Mariona, Pamplona, Reinald, Barja, Gustavo

“…Mitochondria play a wide diversity of roles in cell physiology and have a key functional implication in cell bioenergetics and biology of free radicals. As the…”
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Minireview: The Role of Oxidative Stress in Relation to Caloric Restriction and Longevity by Gredilla, Ricardo, Barja, Gustavo

“…Reduction of caloric intake without malnutrition is one of the most consistent experimental interventions that increases mean and maximum life spans in…”
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Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity by Pamplona, Reinald, Barja, Gustavo

“…Abstract Key characteristics relating oxidative damage to aging and longevity are reviewed. Available information indicates that the specific composition of…”
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Is the mitochondrial free radical theory of aging intact? by Sanz, Alberto, Pamplona, Reinald, Barja, Gustavo

“…The present state of the mitochondrial free radical theory of aging is reviewed. Available studies do not support the hypothesis that antioxidants control the…”
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Low abundance of NDUFV2 and NDUFS4 subunits of the hydrophilic complex I domain and VDAC1 predicts mammalian longevity by Mota-Martorell, Natalia, Jove, Mariona, Pradas, Irene, Sanchez, Isabel, Gómez, José, Naudi, Alba, Barja, Gustavo, Pamplona, Reinald

“…Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species…”
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Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals by Barja, Gustavo, Herrero, Asunción

“…ABSTRACT DNA damage is considered of paramount importance in aging. Among causes of this damage, free radical attack, particularly from mitochondrial origin,…”
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Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins by Sanz, Alberto, Caro, Pilar, Ayala, Victoria, Portero-Otin, Manuel, Pamplona, Reinald, Barja, Gustavo

“…Previous studies have consistently shown that caloric restriction (CR) decreases mitochondrial reactive oxygen species (ROS) (mitROS) generation and oxidative…”
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Elovl2-Ablation Leads to Mitochondrial Membrane Fatty Acid Remodeling and Reduced Efficiency in Mouse Liver Mitochondria by Gómez Rodríguez, Alexia, Talamonti, Emanuela, Naudi, Alba, Kalinovich, Anastasia V, Pauter, Anna M, Barja, Gustavo, Bengtsson, Tore, Jacobsson, Anders, Pamplona, Reinald, Shabalina, Irina G

“…The fatty acid elongase elongation of very long-chain fatty acids protein 2 (ELOVL2) controls the elongation of polyunsaturated fatty acids (PUFA) producing…”
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Methionine Metabolism Is Down-Regulated in Heart of Long-Lived Mammals by Mota-Martorell, Natalia, Jové, Mariona, Berdún, Rebeca, Òbis, Èlia, Barja, Gustavo, Pamplona, Reinald

“…Methionine constitutes a central hub of intracellular metabolic adaptations leading to an extended longevity (maximum lifespan). The present study follows a…”
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Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria by López-Torres, Mónica, Gredilla, Ricardo, Sanz, Alberto, Barja, Gustavo

“…The effect of long-term caloric restriction and aging on the rates of mitochondrial H 2O 2 production and oxygen consumption as well as on oxidative damage to…”
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Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart by Sanchez-Roman, Ines, Gomez, Alexia, Gomez, Jose, Suarez, Henar, Sanchez, Carlota, Naudi, Alba, Ayala, Victoria, Portero-Otin, Manuel, Lopez-Torres, Monica, Pamplona, Reinald, Barja, Gustavo

“…Methionine dietary restriction (MetR), like dietary restriction (DR), increases rodent maximum longevity. However, the mechanism responsible for the…”
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