Search Results - "Barin, Ersilia"

HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells by Nguyen, Diu T. T., Lu, Yuheng, Chu, Eren L., Yang, Xuejing, Park, Sun-Mi, Choo, Zi-Ning, Chin, Christopher R., Prieto, Camila, Schurer, Alexandra, Barin, Ersilia, Savino, Angela M., Gourkanti, Saroj, Patel, Payal, Vu, Ly P., Leslie, Christina S., Kharas, Michael G.

“…The cell-context dependency for RNA binding proteins (RBPs) mediated control of stem cell fate remains to be defined. Here we adapt the HyperTRIBE method using…”
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High Fructose Drives the Serine Synthesis Pathway in Acute Myeloid Leukemic Cells by Jeong, Sangmoo, Savino, Angela Maria, Chirayil, Rachel, Barin, Ersilia, Cheng, Yuanming, Park, Sun-Mi, Schurer, Alexandra, Mullarky, Edouard, Cantley, Lewis C., Kharas, Michael G., Keshari, Kayvan R.

“…A significant increase in dietary fructose consumption has been implicated as a potential driver of cancer. Metabolic adaptation of cancer cells to utilize…”
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Systemic alterations play a dominant role in epigenetic predisposition to breast cancer in offspring of obese fathers and is transmitted to a second generation by Fontelles, Camile C., da Cruz, Raquel Santana, Gonsiewski, Alexandra K., Barin, Ersilia, Tekmen, Volkan, Jin, Lu, Cruz, M. Idalia, Loudig, Olivier, Warri, Anni, de Assis, Sonia

“…We previously showed that environmentally-induced epigenetic inheritance of cancer occurs in rodent models. For instance, we reported that paternal consumption…”
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RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells by Herrejon Chavez, Florisela, Luo, Hanzhi, Cifani, Paolo, Pine, Alli, Chu, Eren L., Joshi, Suhasini, Barin, Ersilia, Schurer, Alexandra, Chan, Mandy, Chang, Kathryn, Han, Grace Y. Q., Pierson, Aspen J., Xiao, Michael, Yang, Xuejing, Kuehm, Lindsey M., Hong, Yuning, Nguyen, Diu T. T., Chiosis, Gabriela, Kentsis, Alex, Leslie, Christina, Vu, Ly P., Kharas, Michael G.

“…Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem…”
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Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment depends on stearoyl-CoA desaturase by Savino, Angela Maria, Fernandes, Sara Isabel, Olivares, Orianne, Zemlyansky, Anna, Cousins, Antony, Markert, Elke K., Barel, Shani, Geron, Ifat, Frishman, Liron, Birger, Yehudit, Eckert, Cornelia, Tumanov, Sergey, MacKay, Gillian, Kamphorst, Jurre J., Herzyk, Pawel, Fernández-García, Jonatan, Abramovich, Ifat, Mor, Inbal, Bardini, Michela, Barin, Ersilia, Janaki-Raman, Sudha, Cross, Justin R., Kharas, Michael G., Gottlieb, Eyal, Izraeli, Shai, Halsey, Christina

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N 6 -Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation by Cheng, Yuanming, Xie, Wei, Pickering, Brian F, Chu, Karen L, Savino, Angela M, Yang, Xuejing, Luo, Hanzhi, Nguyen, Diu Tt, Mo, Shanlan, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas M, Patel, Dinshaw J, Jaffrey, Samie R, Kharas, Michael G

“…N -Methyladenosine (m A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m A dictates its diverse…”
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Abstract 644: Ancestral paternal obesity: Systemic versus local effects on offspring mammary tissue development and tumorigenesis by Fontelles, Camile C., Wärri, Anni, Cruz, Raquel S. Da, Cruz, Maria I., Barin, Ersilia, Assis, Sonia De

“…Background: Obesity and overweight are risk factors for breast cancer, particularly in the post-menopausal years. We recently reported that having a history of…”
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RNA Binding Protein Syncrip Is Required for the Low-Output HSC By Sustaining Proteome Quality by Chavez, Florisela Herrejon, Cifani, Paolo, Pine, Alli, Chu, Karen L, Barin, Ersilia, Schurer, Alexandra, Luo, Hanzhi, Nguyen, Diu T.T., Kentsis, Alex, Leslie, Christina, Kharas, Michael G, Vu, Ly P

“…RNA binding proteins (RBPs) have been increasingly recognized as an important class of regulators of normal and malignant hematopoiesis. However, the exact…”
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BTG1 mutation yields supercompetitive B cells primed for malignant transformation by Mlynarczyk, Coraline, Teater, Matt, Pae, Juhee, Chin, Christopher R, Wang, Ling, Arulraj, Theinmozhi, Barisic, Darko, Papin, Antonin, Hoehn, Kenneth B, Kots, Ekaterina, Ersching, Jonatan, Bandyopadhyay, Arnab, Barin, Ersilia, Poh, Hui Xian, Evans, Chiara M, Chadburn, Amy, Chen, Zhengming, Shen, Hao, Isles, Hannah M, Pelzer, Benedikt, Tsialta, Ioanna, Doane, Ashley S, Geng, Huimin, Rehman, Muhammad Hassan, Melnick, Jonah, Morgan, Wyatt, Nguyen, Diu T T, Elemento, Olivier, Kharas, Michael G, Jaffrey, Samie R, Scott, David W, Khelashvili, George, Meyer-Hermann, Michael, Victora, Gabriel D, Melnick, Ari

“…Multicellular life requires altruistic cooperation between cells. The adaptive immune system is a notable exception, wherein germinal center B cells compete…”
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N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation by Cheng, Yuanming, Xie, Wei, Pickering, Brian F., Chu, Karen L., Savino, Angela M., Yang, Xuejing, Luo, Hanzhi, Nguyen, Diu TT, Mo, Shanlan, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas M., Patel, Dinshaw J., Jaffrey, Samie R., Kharas, Michael G.

“…N6-Methyladenosine (m6A) on mRNAs mediates different biological processes and its dysregulation contributes to tumorigenesis. How m6A dictates its diverse…”
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BTG1 Mutation Promotes Aggressive Lymphoma Development By Lowering the Threshold to MYC Activation and Generating “Super-Competitor” B Cells by Mlynarczyk, Coraline, Teater, Matthew, Pae, Juhee, Arulraj, Theinmozhi, Chin, Christopher R, Wang, Ling, Ersching, Jonatan, Kots, Ekaterina, Chadburn, Amy, Barin, Ersilia, Xian Poh, Hui, Isles, Hannah M, Zhengming, Chen, Shen, Hao, Bandyopadhyay, Arnab, Hoehn, Kenneth B, Nguyen, Diu T.T., Doane, Ashley S, Geng, Huimin, Rehman, Muhammad H, Melnick, Jonah, Morgan, Wyatt, Elemento, Olivier, Kharas, Michael G, Scott, David W., Jaffrey, Samie R, Meyer-Hermann, Michael, Khelashvili, George, Victora, Gabriel, Melnick, Ari

“…Somatic missense mutations of BTG1 are exclusive to germinal center (GC)-derived B cell lymphomas (~12% of DLBCLs) and are most prevalent in ABC-DLBCL…”
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Transcriptional Control of HP1a By the RNA Binding Proteins Rbmx/L1 Maintain Chromatin State in Myeloid Leukemia by Nguyen, Diu T.T., Prieto, Camila, Liu, Zhaoqi, Wheat, Justin, Perez, Alexendar, Gourkanti, Saroj, Chou, Timothy, Barin, Ersilia, Chow, Arthur, Taggart, James, Hoskova, Katerina, Dhodapkar, Meera, Schurer, Alexandra, Barlowe, Trevor Stephen, Vu, Ly, Leslie, Christina, Steidl, Ulrich G., Rabadan, Raul, Kharas, Michael G.

“…Mutations and aberrant expression of RNA binding proteins (RBPs) have recently been found to contribute to leukemia development (Prieto and Kharas, CSH, 2020)…”
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2007 – TRANSCRIPTIONAL CONTROL OF CBX5 BY THE RNA BINDING PROTEINS RBMX AND RBMXL1 MAINTAINS CHROMATIN STATE IN MYELOID LEUKEMIA by Nguyen, Diu, Prieto, Camila, Liu, Zhaoqi, Wheat, Justin, Perez, Alexander, Gourkanti, Saroj, Chou, Timothy, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Chow, Arthur, Taggart, James, Savino, Angela, Hoskova, Katerina, Dhodapkar, Meera, Schurer, Alexandra, Barlowe, trevor, Leslie, Christina, Vu, Ly, Steidl, Ulrich, Rabandan, Raul, Kharas, Michael

“…RNA binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be dysregulated in hematological malignancies. Here, we…”
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Abstract A24: BTG1 mutations confer a fitness advantage and promote aggressive B cell lymphoma development by lowering the threshold for MYC induction by Mlynarczyk, Coraline, Teater, Matt, Pae, Juhee, Wang, Ling, Ersching, Jonatan, Papin, Antonin, Barisic, Darko, Barin, Ersilia, Hoehn, Kenneth B., Chen, Zhengming, Nguyen, Diu T. T., Evans, Chiara, Doane, Ashley S., Kharas, Michael G., Scott, David W., Victora, Gabriel, Melnick, Ari

“…BTG1 somatic mutations are exclusively found in mature B cell malignancies, ~12% diffuse large B cell lymphoma (DLBCL) and are particularly enriched in the…”
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Transcriptional control of CBX5 by the RNA binding proteins RBMX and RBMXL1 maintains chromatin state in myeloid leukemia by Prieto, Camila, Nguyen, Diu T T, Liu, Zhaoqi, Wheat, Justin, Perez, Alexendar, Gourkanti, Saroj, Chou, Timothy, Barin, Ersilia, Velleca, Anthony, Rohwetter, Thomas, Chow, Arthur, Taggart, James, Savino, Angela M, Hoskova, Katerina, Dhodapkar, Meera, Schurer, Alexandra, Barlowe, Trevor S, Vu, Ly P, Leslie, Christina, Steidl, Ulrich, Rabadan, Raul, Kharas, Michael G

“…RNA binding proteins (RBPs) are key arbiters of post-transcriptional regulation and are found to be found dysregulated in hematological malignancies. Here, we…”
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Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase by Savino, Angela Maria, Fernandes, Sara Isabel, Olivares, Orianne, Zemlyansky, Anna, Cousins, Antony, Markert, Elke K, Barel, Shani, Geron, Ifat, Frishman, Liron, Birger, Yehudit, Eckert, Cornelia, Tumanov, Sergey, MacKay, Gillian, Kamphorst, Jurre J, Herzyk, Pawel, Fernández-García, Jonatan, Abramovich, Ifat, Mor, Inbal, Bardini, Michela, Barin, Ersilia, Janaki-Raman, Sudha, Cross, Justin R, Kharas, Michael G, Gottlieb, Eyal, Izraeli, Shai, Halsey, Christina

“…Metabolic reprogramming is a key hallmark of cancer, but less is known about metabolic plasticity of the same tumor at different sites. Here, we investigated…”
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