Search Results - "Barido, Richard"

Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders by Gomez, Laurent, Massari, Mark Eben, Vickers, Troy, Freestone, Graeme, Vernier, William, Ly, Kiev, Xu, Rui, McCarrick, Margaret, Marrone, Tami, Metz, Markus, Yan, Yingzhou G, Yoder, Zachary W, Lemus, Robert, Broadbent, Nicola J, Barido, Richard, Warren, Noelle, Schmelzer, Kara, Neul, David, Lee, Dong, Andersen, Carsten B, Sebring, Kristen, Aertgeerts, Kathleen, Zhou, Xianbo, Tabatabaei, Ali, Peters, Marco, Breitenbucher, J. Guy

“…A series of potent and selective [1,2,4]­triazolo­[1,5-a]­pyrimidine PDE2a inhibitors is reported. The design and improvement of the binding properties of this…”
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Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus by McQuown, Susan, Xia, Shouzhen, Baumgärtel, Karsten, Barido, Richard, Anderson, Gary, Dyck, Brian, Scott, Roderick, Peters, Marco

“…Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this…”
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ACP-103, a 5-hydroxytryptamine 2A receptor inverse agonist, improves the antipsychotic efficacy and side-effect profile of haloperidol and risperidone in experimental models by Gardell, Luis R, Vanover, Kimberly E, Pounds, Linda, Johnson, Robert W, Barido, Richard, Anderson, Gary T, Veinbergs, Isaac, Dyssegaard, Agnete, Brunmark, Per, Tabatabaei, Ali, Davis, Robert E, Brann, Mark R, Hacksell, Uli, Bonhaus, Douglas W

“…Dopamine D(2) receptor antagonism contributes to the therapeutic action of antipsychotic drugs (APDs) but also produces undesirable side effects, including…”
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Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties by Dyck, Brian, Branstetter, Bryan, Gharbaoui, Tawfik, Hudson, Andrew R, Breitenbucher, J. Guy, Gomez, Laurent, Botrous, Iriny, Marrone, Tami, Barido, Richard, Allerston, Charles K, Cedervall, E. Peder, Xu, Rui, Sridhar, Vandana, Barker, Ryan, Aertgeerts, Kathleen, Schmelzer, Kara, Neul, David, Lee, Dong, Massari, Mark Eben, Andersen, Carsten B, Sebring, Kristen, Zhou, Xianbo, Petroski, Robert, Limberis, James, Augustin, Martin, Chun, Lawrence E, Edwards, Thomas E, Peters, Marco, Tabatabaei, Ali

“…A series of potent thienotriazolopyrimidinone-based PDE1 inhibitors was discovered. X-ray crystal structures of example compounds from this series in complex…”
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Design and Synthesis of Novel and Selective Glycine Transporter‑1 (GlyT1) Inhibitors with Memory Enhancing Properties by Santora, Vincent J, Almos, Theresa A, Barido, Richard, Basinger, Jillian, Bellows, Chris L, Bookser, Brett C, Breitenbucher, J. Guy, Broadbent, Nicola J, Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Crickard, Lindsay, Danks, Anne M, Freestone, Graeme C, Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Hudson, Andrew R, Kaplan, Alan P, Kennedy, Michael R, Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C, Na, Jim, Neul, David, Nikpur, John, Peters, Marco, Petroski, Robert E, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Yan, Yingzhuo, Yoder, Zachary W, Zook, Douglas

“…We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors…”
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Azetidine-based selective glycine transporter-1 (GlyT1) inhibitors with memory enhancing properties by Hudson, Andrew R., Santora, Vincent J., Petroski, Robert E., Almos, Theresa A., Anderson, Gary, Barido, Richard, Basinger, Jillian, Bellows, Chris L., Bookser, Brett C., Broadbent, Nicola J., Cabebe, Clifford, Chai, Chih-Kun, Chen, Mi, Chow, Stephine, Chung, De Michael, Heger, Lindsay, Danks, Anne M., Freestone, Graeme C., Gitnick, Dany, Gupta, Varsha, Hoffmaster, Christine, Kaplan, Alan P., Kennedy, Michael R., Lee, Dong, Limberis, James, Ly, Kiev, Mak, Chi Ching, Masatsugu, Brittany, Morse, Andrew C., Na, Jim, Neul, David, Nikpur, John, Renick, Joel, Sebring, Kristen, Sevidal, Samantha, Tabatabaei, Ali, Wen, Jenny, Xia, Shouzhen, Yan, Yingzhuo, Yoder, Zachary W., Zook, Douglas, Peters, Marco, Breitenbucher, J. Guy

“…[Display omitted] A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting…”
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Crew Exploration Vehicle Environmental Control and Life Support Fire Protection Approach by Lewis, John F., Barido, Richard, Tuan, George C.

“…As part of preparing for the Crew Exploration Vehicle (CEV), the National Aeronautics and Space Administration (NASA) worked on developing the requirements to…”
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Development of the Internal Thermal Control System (ITCS) for International Space Station (ISS) by Patel, Vipul P., Barido, Richard, Johnson, Brien, Ibarra, Thomas

“…The International Space Station (ISS) internal thermal control system (ITCS) has been developed jointly by the Boeing Corporation, Huntsville, Alabama, and…”
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