Search Results - "Baribaud, Frederic"
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Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma
Published in Journal of allergy and clinical immunology (01-02-2018)“…Background Sputum analysis in asthmatic patients is used to define airway inflammatory processes and might guide therapy. Objective We sought to determine…”
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Transcriptomic gene signatures associated with persistent airflow limitation in patients with severe asthma
Published in The European respiratory journal (01-09-2017)“…A proportion of severe asthma patients suffers from persistent airflow limitation (PAL), often associated with more symptoms and exacerbations. Little is known…”
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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
Published in Cancer cell (01-07-2006)“…We describe here the existence of a heregulin-HER3 autocrine loop, and the contribution of heregulin-dependent, HER2-mediated HER3 activation to gefitinib…”
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DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets
Published in Journal of Virology (01-09-2006)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344
Published in The Journal of immunology (1950) (15-10-2005)“…This report describes the characterization of INCB3344, a novel, potent and selective small molecule antagonist of the mouse CCR2 receptor. The lack of rodent…”
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Inhaled Steroids and Active Smoking Drive Chronic Obstructive Pulmonary Disease Symptoms and Biomarkers to a Greater Degree Than Airflow Limitation
Published in Biomarker Insights (2017)“…RATIONALE: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease, and development of novel therapeutics requires an understanding of…”
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Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor–neutralizing therapy in patients with inflammatory bowel disease
Published in Nature medicine (01-05-2017)“…The cytokine oncostatin M drives intestinal inflammation in mice, and its abundance in the intestine of patients with inflammatory bowel disease predicts…”
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Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients
Published in Journal of allergy and clinical immunology (01-09-2017)“…Background The Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study profiled patients with mild, moderate, and severe asthma and nonatopic…”
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A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma
Published in Human molecular genetics (01-06-2015)“…Recent advances in genetics have spurred rapid progress towards the systematic identification of genes involved in complex diseases. Still, the detailed…”
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The first‐in‐human study of CNTO 7160, an anti‐interleukin‐33 receptor monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis
Published in British journal of clinical pharmacology (01-12-2020)“…Aims To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti‐interleukin‐33 receptor (IL‐33R)…”
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I_MDS: an inflammatory bowel disease molecular activity score to classify patients with differing disease-driving pathways and therapeutic response to anti-TNF treatment
Published in PLoS computational biology (01-04-2019)“…Crohn's disease and ulcerative colitis are driven by both common and distinct underlying mechanisms of pathobiology. Both diseases, exhibit heterogeneity…”
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Gene Expression Signature for Prediction of Golimumab Response in a Phase 2a Open-Label Trial of Patients With Ulcerative Colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-10-2018)“…Golimumab, a tumor necrosis factor antagonist, is an effective treatment for patients with moderate-to-severe ulcerative colitis (UC); however, more than 50%…”
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Suppression of Serum Interferon‐γ Levels as a Potential Measure of Response to Ustekinumab Treatment in Patients With Systemic Lupus Erythematosus
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-03-2021)“…Objective In a previously reported phase II randomized, placebo‐controlled, interventional trial, we demonstrated that treatment with ustekinumab, an…”
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First‐in‐Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of BMS‐986308: A Renal Outer Medullary Potassium Channel Inhibitor
Published in Clinical pharmacology and therapeutics (02-09-2024)“…In patients with heart failure (HF) who respond inadequately to loop diuretic therapy, BMS‐986308, an oral, selective, reversible renal outer medullary…”
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Assessing fatigue and sleep in chronic diseases using physiological signals from wearables: A pilot study
Published in Frontiers in physiology (14-11-2022)“…Problems with fatigue and sleep are highly prevalent in patients with chronic diseases and often rated among the most disabling symptoms, impairing their…”
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Using a wearable patch to develop a digital monitoring biomarker of inflammation in response to LPS challenge
Published in Clinical and translational science (01-02-2024)“…Remote inflammation monitoring with digital health technologies (DHTs) would provide valuable information for both clinical research and care. Controlled…”
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Gene Expression Profiling and Response Signatures Associated With Differential Responses to Infliximab Treatment in Ulcerative Colitis
Published in The American journal of gastroenterology (01-07-2011)“…Infliximab has been shown to induce clinical response and remission in ulcerative colitis (UC). To characterize the biological response of patients to…”
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Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques
Published in Journal of Virology (01-02-2002)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcriptomic and methylomic features in asthmatic and nonasthmatic twins
Published in Allergy (Copenhagen) (01-04-2020)Get full text
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Regulation of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Fusion by a Membrane-Interactive Domain in the gp41 Cytoplasmic Tail
Published in Journal of Virology (01-10-2005)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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