Search Results - "Barh, Debmalya"
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Anticancer and Antiviral Properties of Cardiac Glycosides: A Review to Explore the Mechanism of Actions
Published in Molecules (Basel, Switzerland) (07-08-2020)“…Cardiac glycosides (CGs) have a long history of treating cardiac diseases. However, recent reports have suggested that CGs also possess anticancer and…”
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Lanatoside C Induces G2/M Cell Cycle Arrest and Suppresses Cancer Cell Growth by Attenuating MAPK, Wnt, JAK-STAT, and PI3K/AKT/mTOR Signaling Pathways
Published in Biomolecules (Basel, Switzerland) (27-11-2019)“…Cardiac glycosides (CGs) are a diverse family of naturally derived compounds having a steroid and glycone moiety in their structures. CG molecules inhibit the…”
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Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19
Published in Computers in biology and medicine (01-11-2020)“…SARS-CoV-2 has ushered a global pandemic with no effective drug being available at present. Although several FDA-approved drugs are currently under clinical…”
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Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms
Published in Viruses (18-04-2021)“…The COVID-19 pandemic has infected millions worldwide, leaving a global burden for long-term care of COVID-19 survivors. It is thus imperative to study…”
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Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview
Published in Frontiers in microbiology (10-10-2017)“…The bacterial communities in a wide range of environmental niches sense and respond to numerous external stimuli for their survival. Primarily, a source they…”
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Structure-Based Design of Novel MAO-B Inhibitors: A Review
Published in Molecules (Basel, Switzerland) (01-06-2023)“…With the significant growth of patients suffering from neurodegenerative diseases (NDs), novel classes of compounds targeting monoamine oxidase type B (MAO-B)…”
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Searching for signatures across microbial communities: Metagenomic analysis of soil samples from mangrove and other ecosystems
Published in Scientific reports (18-08-2017)“…In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast mangrove system in Kerala, India…”
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Genetic Addiction Risk Score (GARS): Molecular Neurogenetic Evidence for Predisposition to Reward Deficiency Syndrome (RDS)
Published in Molecular neurobiology (01-12-2014)“…We have published extensively on the neurogenetics of brain reward systems with reference to the genes related to dopaminergic function in particular. In 1996,…”
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Autoimmunity roots of the thrombotic events after COVID-19 vaccination
Published in Autoimmunity reviews (01-11-2021)“…Although vaccination represents the most promising way to stop or contain the coronavirus disease 2019 (COVID-19) pandemic and safety and effectiveness of…”
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Current Trends in Experimental and Computational Approaches to Combat Antimicrobial Resistance
Published in Frontiers in genetics (06-11-2020)“…A multitude of factors, such as drug misuse, lack of strong regulatory measures, improper sewage disposal, and low-quality medicine and medications, have been…”
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Emergence of Cardiac Glycosides as Potential Drugs: Current and Future Scope for Cancer Therapeutics
Published in Biomolecules (Basel, Switzerland) (25-08-2021)“…Cardiac glycosides are natural sterols and constitute a group of secondary metabolites isolated from plants and animals. These cardiotonic agents are well…”
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Potential chimeric peptides to block the SARS-CoV-2 spike receptor-binding domain [version 1; peer review: 2 approved, 1 approved with reservations]
Published in F1000 research (2020)“…Background: There are no known medicines or vaccines to control the COVID-19 pandemic caused by SARS-CoV-2 (nCoV). Antiviral peptides are superior to…”
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Modular network inference between miRNA–mRNA expression profiles using weighted co-expression network analysis
Published in Journal of integrative bioinformatics (22-11-2021)“…Connecting transcriptional and post-transcriptional regulatory networks solves an important puzzle in the elucidation of gene regulatory mechanisms. To…”
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An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based Approach
Published in International journal of molecular sciences (14-02-2017)“…Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and parasites that are transmitted from one person to another…”
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SARS-CoV-2 Infection, Inflammation, Immunonutrition, and Pathogenesis of COVID-19
Published in Current medicinal chemistry (01-01-2023)“…The COVID-19 pandemic, caused by the coronavirus, SARS-CoV-2, has claimed millions of lives worldwide in the past two years. Fatalities among the elderly with…”
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An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae
Published in PloS one (19-10-2017)“…Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide. The…”
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The Spike of SARS-CoV-2: Uniqueness and Applications
Published in Frontiers in immunology (08-07-2021)“…The Spike (S) protein of the SARS-CoV-2 virus is critical for its ability to attach and fuse into the host cells, leading to infection, and transmission. In…”
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Biomarkers, critical disease pathways, drug targets, and alternative medicine in male breast cancer
Published in Current drug targets (01-01-2009)“…While breast cancer (BC) is commonest malignancy among female with highest death rate, male breast cancer (MBC) is very rare but exhibits highest cancer…”
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Transcriptome profile of Corynebacterium pseudotuberculosis in response to iron limitation
Published in BMC genomics (20-08-2019)“…Iron is an essential micronutrient for the growth and development of virtually all living organisms, playing a pivotal role in the proliferative capability of…”
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Taxonomic classification of strain PO100/5 shows a broader geographic distribution and genetic markers of the recently described Corynebacterium silvaticum
Published in PloS one (21-12-2020)“…The bacterial strain PO100/5 was isolated from a skin abscess taken from a pig (Sus scrofa domesticus) in the Alentejo region of southern Portugal. It was…”
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