Search Results - "Barger, Steven W."

Design, synthesis, and characterization of novel system xC− transport inhibitors: inhibition of microglial glutamate release and neurotoxicity by Gajewski, Mariusz P, Barger, Steven W

“…Abstract Neuroinflammation appears to involve some degree of excitotoxicity promulgated by microglia, which release glutamate via the system x C − (Sx C − )…”
Get full text

A Role for P-Glycoprotein in Clearance of Alzheimer Amyloid β -Peptide from the Brain by Wang, Wei, Bodles-Brakhop, Angela M, Barger, Steven W

“…Most data indicates that Alzheimer's disease involves an accumulation of amyloid β - peptide (Aβ) in the CNS and that sporadic cases arise from a deficiency in…”
Get more information

Serine Racemase Expression Differentiates Aging from Alzheimer's Brain by Wu, Shengzhou, Zhou, Jing, Zhang, He, Barger, Steven W

“…Aging is an inevitable process characterized by progressive loss of physiological integrity and increased susceptibility to cancer, diabetes, cardiovascular,…”
Get more information

Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs by Parcon, Paul A., Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Jones, Richard A., Liu, Ling, Shmookler Reis, Robert J., Barger, Steven W., Mrak, Robert E., Griffin, W. Sue T.

“…Alzheimer apolipoprotein E (APOE) ɛ4/ɛ4 carriers have earlier disease onset and more protein aggregates than patients with other APOE genotypes. Autophagy…”
Get full text

Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis by Griffin, Haven, Sullivan, Sarah C, Barger, Steven W, Phelan, Kevin D, Baldini, Giulia

“…One feature of high-fat diet-induced neurodegeneration in the hypothalamus is an increased level of palmitate, which is associated with endoplasmic reticulum…”
Get full text

Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation by Barger, Steven W, Goodwin, Mary E, Porter, Mandy M, Beggs, Marjorie L

“…When activated by proinflammatory stimuli, microglia release substantial levels of glutamate, and mounting evidence suggests this contributes to neuronal…”
Get full text

Interleukin-1β drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site by Balasubramaniam, Meenakshisundaram, Parcon, Paul A, Bose, Chhanda, Liu, Ling, Jones, Richard A, Farlow, Martin R, Mrak, Robert E, Barger, Steven W, Griffin, W Sue T

“…Neuroinflammation, typified by elevated levels of interleukin-1 (IL-1) α and β, and deficits in proteostasis, characterized by accumulation of…”
Get full text

Interleukin-1 mediates Alzheimer and Lewy body pathologies by Griffin, W Sue T, Liu, Ling, Li, Yuekui, Mrak, Robert E, Barger, Steven W

“…Clinical and neuropathological overlap between Alzheimer's (AD) and Parkinson's disease (PD) is now well recognized. Such cases of concurrent AD and Lewy body…”
Get full text

Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway by Li, Yuekui, Liu, Ling, Barger, Steven W, Griffin, W. Sue T

“…The presence of tangles of abnormally phosphorylated tau is a characteristic of Alzheimer's disease (AD), and the loss of synapses correlates with the degree…”
Get full text

Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend C. elegans Life- and Healthspan by Kakraba, Samuel, Ayyadevara, Srinivas, Mainali, Nirjal, Balasubramaniam, Meenakshisundaram, Bowroju, Suresh, Penthala, Narsimha Reddy, Atluri, Ramani, Barger, Steven W, Griffin, Sue T, Crooks, Peter A, Shmookler Reis, Robert J

“…Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer's disease, cardiomyopathy, and cancer. One of…”
Get full text

Protein Kinases and Parkinson's Disease by Mehdi, Syed Jafar, Rosas-Hernandez, Hector, Cuevas, Elvis, Lantz, Susan M, Barger, Steven W, Sarkar, Sumit, Paule, Merle G, Ali, Syed F, Imam, Syed Z

“…Currently, the lack of new drug candidates for the treatment of major neurological disorders such as Parkinson's disease has intensified the search for drugs…”
Get full text

Genetic Inactivation of D-Amino Acid Oxidase Enhances Extinction and Reversal Learning in Mice by Labrie, Viviane, Duffy, Steven, Wang, Wei, Barger, Steven W, Baker, Glen B, Roder, John C

“…Activation of the N-methyl-d-aspartate receptor (NMDAR) glycine site has been shown to accelerate adaptive forms of learning that may benefit psychopathologies…”
Get full text

A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer's Disease by Kakraba, Samuel, Ayyadevara, Srinivas, Penthala, Narsimha Reddy, Balasubramaniam, Meenakshisundaram, Ganne, Akshatha, Liu, Ling, Alla, Ramani, Bommagani, Shoban Babu, Barger, Steven W, Griffin, W Sue T, Crooks, Peter A, Shmookler Reis, Robert J

“…Age-progressive neurodegenerative pathologies, including Alzheimer's disease (AD), are distinguished and diagnosed by disease-specific components of intra- or…”
Get full text

Rescue of ApoE4-related lysosomal autophagic failure in Alzheimer’s disease by targeted small molecules by Balasubramaniam, Meenakshisundaram, Narasimhappagari, Jagadeesh, Liu, Ling, Ganne, Akshatha, Ayyadevara, Srinivas, Atluri, Ramani, Ayyadevara, Haarika, Caldwell, Guy, Reis, Robert J. Shmookler, Barger, Steven W., Griffin, W. Sue T.

“…Homozygosity for the ε4 allele of APOE increases the odds of developing Alzheimer’s by 12 to 15 times relative to the most common ε3;ε3 genotype, and its…”
Get full text

Nox4-generated superoxide drives angiotensin II-induced neural stem cell proliferation by Topchiy, Elena, Panzhinskiy, Evgeniy, Griffin, W Sue T, Barger, Steven W, Das, Mita, Zawada, W Michael

“…Reactive oxygen species (ROS) have been reported to affect neural stem cell self-renewal and therefore may be important for normal development and may…”
Get more information

Paradoxical roles of serine racemase and d-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis by Thompson, Misty, Marecki, John C., Marinesco, Stephane, Labrie, Viviane, Roder, John C., Barger, Steven W., Crow, John P.

“…J. Neurochem. (2012) 120, 598–610. d‐Serine is an endogenous neurotransmitter that binds to the NMDA receptor, thereby increasing the affinity for glutamate,…”
Get full text

Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function by Barger, Steven W., Basile, Anthony S.

“…Microglial activation as part of a chronic inflammatory response is a prominent component of Alzheimer's disease. Secreted forms of the β‐amyloid precursor…”
Get full text

Overexpression of serine racemase in retina and overproduction of D-serine in eyes of streptozotocin-induced diabetic retinopathy by Jiang, Haiyan, Fang, Junxu, Wu, Bo, Yin, Guibin, Sun, Lin, Qu, Jia, Barger, Steven W, Wu, Shengzhou

“…Recent data indicate that inflammatory mechanisms contribute to diabetic retinopathy (DR). We have determined that serine racemase (SR) expression is increased…”
Get full text

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E by Barger, Steven W, Harmon, Ashley D

“…A role for β-amyloid precursor protein (β-APP) in the development of Alzheimer's disease has been indicated by genetics, and many conditions in which β-APP is…”
Get full text

Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide by Wu, Sheng-Zhou, Bodles, Angela M, Porter, Mandy M, Griffin, W Sue T, Basile, Anthony S, Barger, Steven W

“…BACKGROUND: Roles for excitotoxicity and inflammation in Alzheimer's disease have been hypothesized. Proinflammatory stimuli, including amyloid beta-peptide…”
Get full text