Search Results - "Bareyre, F M"

Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays by Bareyre, Florence M, Schwab, Martin E

“…GeneChip ® microarrays have recently been introduced to the field of neurobiology to identify and monitor the expression levels of thousands of genes…”
Get full text

Mild head injury increasing the brain's vulnerability to a second concussive impact by LAURER, Helmut L, BAREYRE, Florence M, MCINTOSH, Tracy K, LEE, Virginia M. Y. C, TROJANOWSKI, John Q, LONGHI, Luca, HOOVER, Rachel, SAATMAN, Kathryn E, RAGHUPATHI, Ramesh, HOSHINO, Shigeru, GRADY, M. Sean

“…Mild, traumatic repetitive head injury (RHI) leads to neurobehavioral impairment and is associated with the early onset of neurodegenerative disease. The…”
Get full text

Delayed inhibition of Nogo-A does not alter injury-induced axonal sprouting but enhances recovery of cognitive function following experimental traumatic brain injury in rats by Lenzlinger, P.M., Shimizu, S., Marklund, N., Thompson, H.J., Schwab, M.E., Saatman, K.E., Hoover, R.C., Bareyre, F.M., Motta, M., Luginbuhl, A., Pape, R., Clouse, A.K., Morganti-Kossmann, C., McIntosh, T.K.

“…Traumatic brain injury causes long-term neurological motor and cognitive deficits, often with limited recovery. The inability of CNS axons to regenerate…”
Get full text

Pharmacologic inhibition of poly(ADP-ribose) polymerase is neuroprotective following traumatic brain injury in rats by LaPlaca, M C, Zhang, J, Raghupathi, R, Li, J H, Smith, F, Bareyre, F M, Snyder, S H, Graham, D I, McIntosh, T K

“…The nuclear enzyme poly(ADP-ribose) polymerase (PARP), which has been shown to be activated following experimental traumatic brain injury (TBI), binds to DNA…”
Get more information

The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats by Bareyre, Florence M, Kerschensteiner, Martin, Raineteau, Olivier, Mettenleiter, Thomas C, Weinmann, Oliver, Schwab, Martin E

“…In contrast to peripheral nerves, central axons do not regenerate. Partial injuries to the spinal cord, however, are followed by functional recovery. We…”
Get full text

Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats by Bareyre, F M, Saatman, K E, Raghupathi, R, McIntosh, T K

“…The neuroprotective effect of magnesium chloride (MgCl2), a compound previously demonstrated to improve behavioral and neurochemical outcome in several models…”
Get more information

Alterations in ionized and total blood magnesium after experimental traumatic brain injury : Relationship to neurobehavioral outcome and neuroprotective efficacy of magnesium chloride by BAREYRE, F. M, SAATMAN, K. E, HELFAER, M. A, SINSON, G, WEISSER, J. D, BROWN, A. L, MCINTOSH, T. K

“…Experimental evidence suggests that magnesium plays a role in the pathophysiological sequelae of brain injury. The present study examined the variation of…”
Get full text

Postinjury Magnesium Treatment Attenuates Traumatic Brain Injury-Induced Cortical Induction of p53 mRNA in Rats by Muir, Judith K., Raghupathi, Ramesh, Emery, Dana L., Bareyre, Florence M., McIntosh, Tracy K.

“…Administration of magnesium has been shown to be neuroprotective in experimental models of traumatic brain injury (TBI). The present study examined the effect…”
Get full text

Long-Lasting Sprouting and Gene Expression Changes Induced by the Monoclonal Antibody IN-1 in the Adult Spinal Cord by Bareyre, Florence M, Haudenschild, Brigitte, Schwab, Martin E

“…Lesion-induced plasticity of the rat corticospinal tract (CST) decreases postnatally, simultaneously with myelin appearance. In adult rats, compensatory…”
Get full text

The novel compound LOE 908 attenuates acute neuromotor dysfunction but not cognitive impairment or cortical tissue loss following traumatic brain injury in rats by Cheney, J A, Brown, A L, Bareyre, F M, Russ, A B, Weisser, J D, Ensinger, H A, Leusch, A, Raghupathi, R, Saatman, K E

“…Experimental traumatic brain injury (TBI) initiates massive disturbances in Ca2+ concentrations in the brain that may contribute to neuronal damage…”
Get more information

Acute Cytoskeletal Alterations and Cell Death Induced by Experimental Brain Injury Are Attenuated by Magnesium Treatment and Exacerbated by Magnesium Deficiency by SAATMAN, KATHRYN E, BAREYRE, FLORENCE M, GRADY, M SEAN, MCINTOSH, TRACY K

“…Traumatic brain injury results in a profound decline in intracellular magnesium ion levels that may jeopardize critical cellular functions. We examined the…”
Get full text

Effects of chronic, post-injury Cyclosporin A administration on motor and sensorimotor function following severe, experimental traumatic brain injury by Riess, P, Bareyre, F M, Saatman, K E, Cheney, J A, Lifshitz, J, Raghupathi, R, Grady, M S, Neugebauer, E, McIntosh, T K

“…Cyclosporin A (CsA) is widely used in clinical situations to attenuate graft rejection following organ and central nervous system transplantation. Previous…”
Get more information

Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury by Sanes, Joshua R, Bareyre, Florence M, Kerschensteiner, Martin, Misgeld, Thomas

“…The rodent corticospinal tract (CST) has been used extensively to investigate regeneration and remodeling of central axons after injury. CST axons are…”
Get full text

The Maxi-K Channel Opener BMS-204352 Attenuates Regional Cerebral Edema and Neurologic Motor Impairment After Experimental Brain Injury by Cheney, Jessica A., Weisser, Justin D., Bareyre, Florence M., Laurer, Helmut L., Saatman, Kathryn E., Raghupathi, Ramesh, Gribkoff, Valentin, Starrett, John E., McIntosh, Tracy K.

“…Large-conductance, calcium-activated potassium (maxi-K) channels regulate neurotransmitter release and neuronal excitability, and openers of these channels…”
Get full text

Reorganization of descending motor tracts in the rat spinal cord by Raineteau, Olivier, Fouad, Karim, Bareyre, Florence M., Schwab, Martin E.

“…Following lesion of the central nervous system (CNS), reinnervation of denervated areas may occur via two distinct processes: regeneration of the lesioned…”
Get full text

Anti-Nogo-A Antibody Infusion 24 Hours After Experimental Stroke Improved Behavioral Outcome and Corticospinal Plasticity in Normotensive and Spontaneously Hypertensive Rats by Wiessner, Christoph, Bareyre, Florence M., Allegrini, Peter R., Mir, Anis K., Frentzel, Stefan, Zurini, Mauro, Schnell, Lisa, Oertle, Thomas, Schwab, Martin E.

“…Nogo-A is a myelin-associated neurite outgrowth inhibitory protein limiting recovery and plasticity after central nervous system injury. In this study, a…”
Get full text

Remodeling of axonal connections contributes to recovery in an animal model of multiple sclerosis by Kerschensteiner, Martin, Bareyre, Florence M, Buddeberg, Bigna S, Merkler, Doron, Stadelmann, Christine, Brück, Wolfgang, Misgeld, Thomas, Schwab, Martin E

“…In multiple sclerosis (MS), inflammation in the central nervous system (CNS) leads to damage of axons and myelin. Early during the clinical course, patients…”
Get full text

Targeting Experimental Autoimmune Encephalomyelitis Lesions to a Predetermined Axonal Tract System Allows for Refined Behavioral Testing in an Animal Model of Multiple Sclerosis by Kerschensteiner, Martin, Stadelmann, Christine, Buddeberg, Bigna S., Merkler, Doron, Bareyre, Florence M., Anthony, Daniel C., Linington, Christopher, Brück, Wolfgang, Schwab, Martin E.

“…In multiple sclerosis (MS) the structural damage to axons determines the persistent clinical deficit patients acquire during the course of the disease. It is…”
Get full text

DNase I disinhibition is predominantly associated with actin hyperpolymerization after traumatic brain injury by Bareyre, Florence M., Raghupathi, Ramesh, Saatman, Kathryn E., McIntosh, Tracy K.

“…To elucidate a role for the cytoskeletal protein actin in post‐traumatic apoptotic cell death, the ability of actin‐containing tissue extracts to inhibit…”
Get full text

Peptide tags for labeling membrane proteins in live cells with multiple fluorophores by McCann, Corey M, Bareyre, Florence M, Lichtman, Jeff W, Sanes, Joshua R

“…We describe a method to label specific membrane proteins with fluorophores for live imaging. Fusion proteins are generated that incorporate into their…”
Get full text