Search Results - "Barennes, Pierre"
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Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases
Published in Nature biotechnology (01-02-2021)“…Monitoring the T cell receptor (TCR) repertoire in health and disease can provide key insights into adaptive immune responses, but the accuracy of current TCR…”
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High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells
Published in Proceedings of the National Academy of Sciences - PNAS (18-09-2018)“…T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ…”
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Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling
Published in eLife (26-05-2021)“…Use of adaptive immune receptor repertoire sequencing (AIRR-seq) has become widespread, providing new insights into the immune system with potential broad…”
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Long-lived central memory γδ T cells confer protection against murine cytomegalovirus reinfection
Published in PLoS pathogens (01-07-2024)“…The involvement of ©δ TCR-bearing lymphocytes in immunological memory has gained increasing interest due to their functional duality between adaptive and…”
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Human thymopoiesis produces polyspecific CD8 + α/β T cells responding to multiple viral antigens
Published in eLife (30-03-2023)“…T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >10 sequences. They are selected during thymopoiesis, which…”
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Long-lived central memory [gamma][delta] T cells confer protection against murine cytomegalovirus reinfection
Published in PLoS pathogens (08-07-2024)“…The involvement of [gamma][delta] TCR-bearing lymphocytes in immunological memory has gained increasing interest due to their functional duality between…”
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Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice
Published in Diabetes (New York, N.Y.) (01-04-2021)“…Regulatory T cell (Treg) insufficiency licenses the destruction of insulin-producing pancreatic β-cells by autoreactive effector T cells (Teffs), causing…”
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Immunological Profiling of Pain in Knee Osteoarthritis: Treg Cells as Potential New Key Players in Symptomatic Knee Osteoarthritis
Published in Osteoarthritis and cartilage (01-04-2024)Get full text
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Enhancing comparative T cell receptor repertoire analysis in small biological samples through pooling homologous cell samples from multiple mice
Published in Cell reports methods (22-04-2024)“…Accurate characterization and comparison of T cell receptor (TCR) repertoires from small biological samples present significant challenges. The main challenge…”
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Human thymopoiesis produces polyspecific CD8.sup.+ [alpha]/[beta] T cells responding to multiple viral antigens
Published in eLife (30-03-2023)“…T-cell receptors (TCRs) are formed by stochastic gene rearrangements, theoretically generating >10.sup.19 sequences. They are selected during thymopoiesis,…”
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Intrathymic adeno-associated virus gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells
Published in Journal of allergy and clinical immunology (01-02-2020)“…Patients with T-cell immunodeficiencies are generally treated with allogeneic hematopoietic stem cell transplantation, but alternatives are needed for patients…”
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Intrathymic AAV gene transfer rapidly restores thymic function and long-term persistence of gene-corrected T cells
Published in Journal of allergy and clinical immunology (09-09-2019)Get full text
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