Search Results - "Barends, Thomas RM"

Tryptophan synthase, an allosteric molecular factory by Barends, Thomas RM, Dunn, Michael F, Schlichting, Ilme

“…Tryptophan synthase (TrpS) is a pyridoxal phosphate-containing bifunctional enzyme that catalyzes the last two steps in the biosynthesis of l-tryptophan…”
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Rare earth metals are essential for methanotrophic life in volcanic mudpots by Pol, Arjan, Barends, Thomas R. M., Dietl, Andreas, Khadem, Ahmad F., Eygensteyn, Jelle, Jetten, Mike S. M., Op den Camp, Huub J. M.

“…Summary Growth of Methylacidiphilum fumariolicum SolV, an extremely acidophilic methanotrophic microbe isolated from an Italian volcanic mudpot, is shown to be…”
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Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-ray Laser by Redecke, Lars, Nass, Karol, Deponte, Daniel P., White, Thomas A., Rehders, Dirk, Barty, Anton, Stellato, Francesco, Liang, Mengning, Barends, Thomas R.M., Boutet, Sébastien, Williams, Garth J., Messerschmidt, Marc, Seibert, M. Marvin, Aquila, Andrew, Arnlund, David, Bajt, Sasa, Barth, Torsten, Bogan, Michael J., Caleman, Carl, Chao, Tzu-Chiao, Doak, R. Bruce, Fleckenstein, Holger, Frank, Matthias, Fromme, Raimund, Galli, Lorenzo, Grotjohann, Ingo, Hunter, Mark S., Johansson, Linda C., Kassemeyer, Stephan, Katona, Gergely, Kirian, Richard A., Koopmann, Rudolf, Kupitz, Chris, Lomb, Lukas, Martin, Andrew V., Mogk, Stefan, Neutze, Richard, Shoeman, Robert L., Steinbrener, Jan, Timneanu, Nicusor, Wang, Dingjie, Weierstall, Uwe, Zatsepin, Nadia A., Spence, John C. H., Fromme, Petra, Schlichting, Ilme, Duszenko, Michael, Betzel, Christian, Chapman, Henry N.

“…The Trypanosoma brucei cysteine protease cathepsin B (TbCatB), which is involved in host protein degradation, is a promising target to develop new treatments…”
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Structural analysis of an oxygen-regulated diguanylate cyclase by Tarnawski, Miroslaw, Barends, Thomas R. M., Schlichting, Ilme

“…Cyclic di‐GMP is a bacterial second messenger that is involved in switching between motile and sessile lifestyles. Given the medical importance of biofilm…”
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Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase by Schlichting, Ilme, Barends, Thomas R. M, Shoeman, Robert L, Griese, Julia J, Gomelsky, Mark, Hartmann, Elisabeth, Beitlich, Thorsten, Ryjenkov, Dmitri A, Kirienko, Natalia V, Reinstein, Jochen

“…The ability to respond to light is crucial for most organisms. BLUF is a recently identified photoreceptor protein domain that senses blue light using a FAD…”
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Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme by Benjdia, Alhosna, Heil, Korbinian, Barends, Thomas R M, Carell, Thomas, Schlichting, Ilme

“…Bacterial spores possess an enormous resistance to ultraviolet (UV) radiation. This is largely due to a unique DNA repair enzyme, Spore Photoproduct Lyase (SP…”
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Crystallography on a chip by Zarrine-Afsar, Arash, Barends, Thomas R. M., Müller, Christina, Fuchs, Martin R., Lomb, Lukas, Schlichting, Ilme, Miller, R. J. Dwayne

“…A new chip‐based crystal‐mounting approach for rapid room‐temperature data collection from numerous crystals is described. This work was motivated by the…”
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Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon by Smeulders, Marjan J., Barends, Thomas R. M., Pol, Arjan, Scherer, Anna, Zandvoort, Marcel H., Udvarhelyi, Anikó, Khadem, Ahmad F., Menzel, Andreas, Hermans, John, Shoeman, Robert L., Wessels, Hans J. C. T., van den Heuvel, Lambert P., Russ, Lina, Schlichting, Ilme, Jetten, Mike S. M., Op den Camp, Huub J. M.

“…Evolution of novel enzyme activity Many extremophilic organisms require unusual enzymes to help them survive in harsh environments. For example, acid-loving…”
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Disaggregases in 4 dimensions by Barends, Thomas RM, Werbeck, Nicolas D, Reinstein, Jochen

“…Non-destructive dissagregation of protein aggregates is a formidable task mediated by the specialized AAA+ chaperone Hsp104/ClpB in combination with the…”
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Anomalous signal from S atoms in protein crystallographic data from an X-ray free-electron laser by Barends, Thomas R. M., Foucar, Lutz, Shoeman, Robert L., Bari, Sadia, Epp, Sascha W., Hartmann, Robert, Hauser, Gunter, Huth, Martin, Kieser, Christian, Lomb, Lukas, Motomura, Koji, Nagaya, Kiyonobu, Schmidt, Carlo, Strecker, Rafael, Anielski, Denis, Boll, Rebecca, Erk, Benjamin, Fukuzawa, Hironobu, Hartmann, Elisabeth, Hatsui, Takaki, Holl, Peter, Inubushi, Yuichi, Ishikawa, Tetsuya, Kassemeyer, Stephan, Kaiser, Christian, Koeck, Frank, Kunishima, Naoki, Kurka, Moritz, Rolles, Daniel, Rudek, Benedikt, Rudenko, Artem, Sato, Takahiro, Schroeter, Claus-Dieter, Soltau, Heike, Strueder, Lothar, Tanaka, Tomoyuki, Togashi, Tadashi, Tono, Kensuke, Ullrich, Joachim, Yase, Satoshi, Wada, Shin-ichi, Yao, Makoto, Yabashi, Makina, Ueda, Kiyoshi, Schlichting, Ilme

“…X‐ray free‐electron lasers (FELs) enable crystallographic data collection using extremely bright femtosecond pulses from microscopic crystals beyond the…”
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Combining crystallography and EPR: crystal and solution structures of the multidomain cochaperone DnaJ by Barends, Thomas R. M., Brosi, Richard W. W., Steinmetz, Andrea, Scherer, Anna, Hartmann, Elisabeth, Eschenbach, Jessica, Lorenz, Thorsten, Seidel, Ralf, Shoeman, Robert L., Zimmermann, Sabine, Bittl, Robert, Schlichting, Ilme, Reinstein, Jochen

“…Hsp70 chaperones assist in a large variety of protein‐folding processes in the cell. Crucial for these activities is the regulation of Hsp70 by Hsp40…”
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Structures of the catalytic EAL domain of the Escherichia coli direct oxygen sensor by Tarnawski, Miroslaw, Barends, Thomas R. M., Hartmann, Elisabeth, Schlichting, Ilme

“…The direct oxygen sensor DosP is a multidomain protein that contains a gas‐sensing haem domain and an EAL effector domain. EAL domains are omnipresent signal…”
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Bacterial CS2 Hydrolases from Acidithiobacillus thiooxidans Strains Are Homologous to the Archaeal Catenane CS2 Hydrolase by Smeulders, Marjan J, Pol, Arjan, Venselaar, Hanka, Barends, Thomas R. M, Hermans, John, Jetten, Mike S. M, Op den Camp, Huub J. M

“…Carbon disulfide (CS2) and carbonyl sulfide (COS) are important in the global sulfur cycle, and CS2 is used as a solvent in the viscose industry. These…”
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Bacterial CS^sub 2^ Hydrolases from Acidithiobacillus thiooxidans Strains Are Homologous to the Archaeal Catenane CS^sub 2^ Hydrolase by Smeulders, Marjan J, Pol, Arjan, Venselaar, Hanka, Barends, Thomas RM, Hermans, John, Jetten, Mike SM, den Camp, Huub JM Op

“…Carbon disulfide (CS2) and carbonyl sulfide (COS) are important in the global sulfur cycle, and CS2 is used as a solvent in the viscose industry. These…”
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Structure of Escherichia coli Lytic transglycosylase MltA with bound chitohexaose: implications for peptidoglycan binding and cleavage by van Straaten, Karin E, Barends, Thomas R M, Dijkstra, Bauke W, Thunnissen, Andy-Mark W H

“…Crystal structures of an inactive mutant (D308A) of the lytic transglycosylase MltA from Escherichia coli have been determined in two different apo-forms, as…”
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Serial femtosecond X-ray diffraction of 30S ribosomal subunit microcrystals in liquid suspension at ambient temperature using an X-ray free-electron laser by Demirci, Hasan, Sierra, Raymond G., Laksmono, Hartawan, Shoeman, Robert L., Botha, Sabine, Barends, Thomas R. M., Nass, Karol, Schlichting, Ilme, Doak, R. Bruce, Gati, Cornelius, Williams, Garth J., Boutet, Sébastien, Messerschmidt, Marc, Jogl, Gerwald, Dahlberg, Albert E., Gregory, Steven T., Bogan, Michael J.

“…High‐resolution ribosome structures determined by X‐ray crystallography have provided important insights into the mechanism of translation. Such studies have…”
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Acetobacter turbidans alpha-amino acid ester hydrolase: how a single mutation improves an antibiotic-producing enzyme by Barends, Thomas R M, Polderman-Tijmes, Jolanda J, Jekel, Peter A, Williams, Christopher, Wybenga, Gjalt, Janssen, Dick B, Dijkstra, Bauke W

“…The alpha-amino acid ester hydrolase (AEH) from Acetobacter turbidans is a bacterial enzyme catalyzing the hydrolysis and synthesis of beta-lactam antibiotics…”
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Three-dimensional structures of enzymes useful for β-lactam antibiotic production by Barends, Thomas RM, Yoshida, Hiromi, Dijkstra, Bauke W

“…Significant advances have been made in the structure-based engineering of enzymes useful for β-lactam antibiotic production. Structure-based engineering of…”
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