Search Results - "Bardowell, Sabrina A."

Disruption of Mouse Cytochrome P450 4f14 (Cyp4f14 Gene) Causes Severe Perturbations in Vitamin E Metabolism by Bardowell, Sabrina A., Duan, Faping, Manor, Danny, Swanson, Joy E., Parker, Robert S.

“…Background: Human CYP4F2 metabolizes vitamin E, but its role in vivo is unknown. Results: Disruption of Cyp4f14, a murine ortholog of CYP4F2, severely alters…”
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Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism by Bardowell, Sabrina A., Ding, Xinxin, Parker, Robert S.

“…The widely conserved preferential accumulation of α-tocopherol (α-TOH) in tissues occurs, in part, from selective postabsorptive catabolism of non-α-TOH forms…”
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Differential methylation relative to breast cancer subtype and matched normal tissue reveals distinct patterns by Bardowell, Sabrina A., Parker, Joel, Fan, Cheng, Crandell, Jamie, Perou, Charles M., Swift-Scanlan, Theresa

“…Due to the heterogeneous nature of breast cancer and the widespread use of single-gene studies, there is limited knowledge of multi-gene, locus-specific DNA…”
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Comprehensive interrogation of CpG island methylation in the gene encoding COMT, a key estrogen and catecholamine regulator by Swift-Scanlan, Theresa, Smith, Christopher T, Bardowell, Sabrina A, Boettiger, Charlotte A

“…The catechol-O-methyltransferase (COMT) enzyme has been widely studied due to its multiple roles in neurological functioning, estrogen biology, and methylation…”
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Common variants of cytochrome P450 4F2 exhibit altered vitamin E-{omega}-hydroxylase specific activity by Bardowell, Sabrina A, Stec, David E, Parker, Robert S

“…Human cytochrome P450 4F2 (CYP4F2) catalyzes the ω-hydroxylation of the side chain of tocopherols (TOH) and tocotrienols (T3), the first step in their…”
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