Search Results - "Bardor, Muriel"

Comparative RNA-Seq of Ten Phaeodactylum tricornutum Accessions: Unravelling Criteria for Robust Strain Selection from a Bioproduction Point of View by Toustou, Charlotte, Boulogne, Isabelle, Gonzalez, Anne-Alicia, Bardor, Muriel

“…The production of biologics in mammalian cells is hindered by some limitations including high production costs, prompting the exploration of other alternative…”
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Diatom-Specific Oligosaccharide and Polysaccharide Structures Help to Unravel Biosynthetic Capabilities in Diatoms by Gügi, Bruno, Le Costaouec, Tinaïg, Burel, Carole, Lerouge, Patrice, Helbert, William, Bardor, Muriel

“…Diatoms are marine organisms that represent one of the most important sources of biomass in the ocean, accounting for about 40% of marine primary production,…”
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Investigation of the N -Glycosylation of the SARS-CoV-2 S Protein Contained in VLPs Produced in Nicotiana benthamiana by Balieu, Juliette, Jung, Jae-Wan, Chan, Philippe, Lomonossoff, George P, Lerouge, Patrice, Bardor, Muriel

“…The emergence of the SARS-CoV-2 coronavirus pandemic in China in late 2019 led to the fast development of efficient therapeutics. Of the major structural…”
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N - and O -Glycosylation Pathways in the Microalgae Polyphyletic Group by Mathieu-Rivet, Elodie, Mati-Baouche, Narimane, Walet-Balieu, Marie-Laure, Lerouge, Patrice, Bardor, Muriel

“…The term microalga refers to various unicellular and photosynthetic organisms representing a polyphyletic group. It gathers numerous species, which can be…”
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Plant Immunity Is Compartmentalized and Specialized in Roots by Chuberre, Coralie, Plancot, Barbara, Driouich, Azeddine, Moore, John P, Bardor, Muriel, Gügi, Bruno, Vicré, Maïté

“…Roots are important organs for plant survival. In recent years, clear differences between roots and shoots in their respective plant defense strategies have…”
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Microalgae as an Efficient Vehicle for the Production and Targeted Delivery of Therapeutic Glycoproteins against SARS-CoV-2 Variants by Dehghani, Jaber, Movafeghi, Ali, Mathieu-Rivet, Elodie, Mati-Baouche, Narimane, Calbo, Sébastien, Lerouge, Patrice, Bardor, Muriel

“…Severe acute respiratory syndrome–Coronavirus 2 (SARS-CoV-2) can infect various human organs, including the respiratory, circulatory, nervous, and…”
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Biochemical Characterization of Human Anti-Hepatitis B Monoclonal Antibody Produced in the Microalgae Phaeodactylum tricornutum by Vanier, Gaëtan, Hempel, Franziska, Chan, Philippe, Rodamer, Michael, Vaudry, David, Maier, Uwe G, Lerouge, Patrice, Bardor, Muriel

“…Monoclonal antibodies (mAbs) represent actually the major class of biopharmaceuticals. They are produced recombinantly using living cells as biofactories…”
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Cell wall O-glycoproteins and N-glycoproteins: aspects of biosynthesis and function by Nguema-Ona, Eric, Vicré-Gibouin, Maïté, Gotté, Maxime, Plancot, Barbara, Lerouge, Patrice, Bardor, Muriel, Driouich, Azeddine

“…Cell wall O-glycoproteins and N-glycoproteins are two types of glycomolecules whose glycans are structurally complex. They are both assembled and modified…”
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The SARS-CoV-2 Spike Protein Receptor-Binding Domain Expressed in Rice Callus Features a Homogeneous Mix of Complex-Type Glycans by Sobrino-Mengual, Guillermo, Armario-Nájera, Victoria, Balieu, Juliette, Walet-Balieu, Marie-Laure, Saba-Mayoral, Andrea, Pelacho, Ana M, Capell, Teresa, Christou, Paul, Bardor, Muriel, Lerouge, Patrice

“…The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is required for the infection of human cells. It is the main target that elicits neutralizing…”
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Characterization of a GDP-Fucose Transporter and a Fucosyltransferase Involved in the Fucosylation of Glycoproteins in the Diatom Phaeodactylum tricornutum by Zhang, Peiqing, Burel, Carole, Plasson, Carole, Kiefer-Meyer, Marie-Christine, Ovide, Clément, Gügi, Bruno, Wan, Corrine, Teo, Gavin, Mak, Amelia, Song, Zhiwei, Driouich, Azeddine, Lerouge, Patrice, Bardor, Muriel

“…Although is gaining importance in plant molecular farming for the production of high-value molecules such as monoclonal antibodies, little is currently known…”
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Mechanism of Uptake and Incorporation of the Non-human Sialic Acid N-Glycolylneuraminic Acid into Human Cells by Bardor, Muriel, Nguyen, Dzung H., Diaz, Sandra, Varki, Ajit

“…N-Glycolylneuraminic acid (Neu5Gc) is a widely expressed sialic acid in mammalian cells. Although humans are genetically deficient in producing Neu5Gc, small…”
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Engineering the interactions between a plant‐produced HIV antibody and human Fc receptors by Stelter, Szymon, Paul, Mathew J., Teh, Audrey Y.‐H., Grandits, Melanie, Altmann, Friedrich, Vanier, Jessica, Bardor, Muriel, Castilho, Alexandra, Allen, Rachel Louise, Ma, Julian K‐C.

“…Summary Plants can provide a cost‐effective and scalable technology for production of therapeutic monoclonal antibodies, with the potential for precise…”
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Comparative Structural and Functional Analyses of the Fusiform, Oval, and Triradiate Morphotypes of Phaeodactylum tricornutum Pt3 Strain by Galas, Ludovic, Burel, Carole, Schapman, Damien, Ropitaux, Marc, Bernard, Sophie, Bénard, Magalie, Bardor, Muriel

“…The diatom is a marine unicellular microalga that exists under three main morphotypes: oval, fusiform, and triradiate. Previous works have demonstrated that…”
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Comparison of two Phaeodactylum tricornutum ecotypes under nitrogen starvation and resupply reveals distinct lipid accumulation strategies but a common degradation process by Murison, Victor, Hérault, Josiane, Côme, Martine, Guinio, Sabrina, Lebon, Alexis, Chamot, Christophe, Bénard, Magalie, Galas, Ludovic, Schoefs, Benoît, Marchand, Justine, Bardor, Muriel, Ulmann, Lionel

“…Introduction Phaeodactylum tricornutum is a model species frequently used to study lipid metabolism in diatoms. When exposed to a nutrient limitation or…”
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IRES-mediated Tricistronic vectors for enhancing generation of high monoclonal antibody expressing CHO cell lines by Ho, Steven C.L., Bardor, Muriel, Feng, Huatao, Mariati, Tong, Yen Wah, Song, Zhiwei, Yap, Miranda G.S., Yang, Yuansheng

“…A Tricistronic vector utilizing internal ribosome entry site (IRES) elements to express the light chain (LC), heavy chain (HC), and a neomycin…”
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Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability by Ho, Steven C.L., Koh, Esther Y.C., van Beers, Miranda, Mueller, Monika, Wan, Corrine, Teo, Gavin, Song, Zhiwei, Tong, Yen Wah, Bardor, Muriel, Yang, Yuansheng

“…•We designed four IRES-mediated tricistronic vectors which enable control of LC:HC expression to different ratios.•Expressing excess LC aided in the…”
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Exploring the N-glycosylation Pathway in Chlamydomonas reinhardtii Unravels Novel Complex Structures by Mathieu-Rivet, Elodie, Scholz, Martin, Arias, Carolina, Dardelle, Flavien, Schulze, Stefan, Le Mauff, François, Teo, Gavin, Hochmal, Ana Karina, Blanco-Rivero, Amaya, Loutelier-Bourhis, Corinne, Kiefer-Meyer, Marie-Christine, Fufezan, Christian, Burel, Carole, Lerouge, Patrice, Martinez, Flor, Bardor, Muriel, Hippler, Michael

“…Chlamydomonas reinhardtii is a green unicellular eukaryotic model organism for studying relevant biological and biotechnological questions. The availability of…”
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Human Uptake and Incorporation of an Immunogenic Nonhuman Dietary Sialic Acid by Tangvoranuntakul, Pam, Gagneux, Pascal, Diaz, Sandra, Bardor, Muriel, Varki, Nissi, Varki, Ajit, Muchmore, Elaine

“…Humans are genetically unable to produce the sialic acid N-glycolylneuraminic acid (Neu5Gc), because of a mutation that occurred after our last common ancestor…”
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Protein N-glycosylation in eukaryotic microalgae and its impact on the production of nuclear expressed biopharmaceuticals by Mathieu-Rivet, Elodie, Kiefer-Meyer, Marie-Christine, Vanier, Gaëtan, Ovide, Clément, Burel, Carole, Lerouge, Patrice, Bardor, Muriel

“…Microalgae are currently used for the production of food compounds. Recently, few microalgae species have been investigated as potential biofactories for the…”
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Performance of plant-produced RBDs as SARS-CoV-2 diagnostic reagents: a tale of two plant platforms by Santoni, Mattia, Gutierrez-Valdes, Noemi, Pivotto, Denise, Zanichelli, Elena, Rosa, Anthony, Sobrino-Mengual, Guillermo, Balieu, Juliette, Lerouge, Patrice, Bardor, Muriel, Cecchetto, Riccardo, Compri, Monica, Mazzariol, Annarita, Ritala, Anneli, Avesani, Linda

“…The COVID-19 pandemic has underscored the need for rapid and cost-effective diagnostic tools. Serological tests, particularly those measuring antibodies…”
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