Search Results - "Barden, Timothy C"

Pharmacokinetics, mass balance, tissue distribution, metabolism, and excretion of praliciguat, a clinical‐stage soluble guanylate cyclase stimulator in rats by Banijamali, Ali R., Carvalho, Andrew E., Wakefield, James D., Germano, Peter, Barden, Timothy C., Tobin, Jenny V., Zimmer, Daniel P., Masferrer, Jaime L., Profy, Albert T., Currie, Mark G., Todd Milne, G.

“…The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a…”
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Discovery of CYR715: A novel carboxylic acid-containing soluble guanylate cyclase stimulator by Rennie, Glen R., Barden, Timothy C., Bernier, Sylvie G., Carvalho, Andrew, Deming, Renee, Germano, Peter, Hudson, Colleen, Im, G-Yoon J., Iyengar, Rajesh R., Jia, Lei, Jung, Joon, Kim, Elise, Lee, Thomas W.-H., Mermerian, Ara, Moore, Joel, Nakai, Takashi, Perl, Nicholas R., Tobin, Jenny, Zimmer, Daniel P., Renhowe, Paul A.

“…[Display omitted] Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC…”
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Discovery of IWP-051, a Novel Orally Bioavailable sGC Stimulator with Once-Daily Dosing Potential in Humans by Nakai, Takashi, Perl, Nicholas R, Barden, Timothy C, Carvalho, Andrew, Fretzen, Angelika, Germano, Peter, Im, G-Yoon J, Jin, Hong, Kim, Charles, Lee, Thomas W.-H, Long, Kimberly, Moore, Joel, Rohde, Jason M, Sarno, Renee, Segal, Chrissie, Solberg, Erik O, Tobin, Jenny, Zimmer, Daniel P, Currie, Mark G

“…In recent years, soluble guanylate cyclase (sGC, EC 4.6.1.2) has emerged as an attractive therapeutic target for treating cardiovascular diseases and diseases…”
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Nucleophilic addition reactions of 2-nitro-1-(phenylsulfonyl)indole. A new synthesis of 3-substituted-2-nitroindoles by Pelkey, Erin T., Barden, Timothy C., Gribble, Gordon W.

“…2-Nitro-1-(phenylsulfonyl)indole ( 1) undergoes nucleophilic addition reactions with the enolates of diethyl malonate and cyclohexanone, lithium…”
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Discrimination between exo- and endo-3,2-methyl shifts in substituted 2-norbornyl cations on the (+)-camphenilone route to (-)-albene by Baldwin, John E, Barden, Timothy C

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Syntheses and Diels-Alder cycloaddition reactions of 4H-furo[3,4-b]indoles. A regiospecific Diels-Alder synthesis of ellipticine by Gribble, Gordon W., Keavy, Daniel J., Davis, Deborah A., Saulnier, Mark G., Pelcman, Benjamin, Barden, Timothy C., Sibi, Mukund P., Olson, Erik R., BelBruno, Joseph J.

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Thermal stereomutations of (2R,3R)-phenylcyclopropane-1,2,3-2H3 and (1R,2S,3R)-phenylcyclopropane-2-13C-1,2,3-2H3: quantification of all four stereochemical modes for interconversions among the 1-phenyl-1,2,3-trideuteriocyclopropanes by Baldwin, John E, Barden, Timothy C

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"Glycylcyclines". 3. 9-Aminodoxycyclinecarboxamides by Barden, Timothy C, Buckwalter, Brian L, Testa, Raymond T, Petersen, Peter J, Lee, Ving J

“…A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline…”
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Restricted Nitrogen Inversion in 9,10- Diazatetracyclo[6.3.0.0.4,110.5,9]undecanes. Dynamic NMR Studies by Bushweller, C. Hackett, Brown, Jay H, Harpp, Karen S, Hirth, Bradford H, Barden, Timothy C, D'Albi, John N, Gribble, Gordon W

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Stereocontrolled total syntheses of (-)-hobartine and (+)-aristoteline via an intramolecular nitrone-olefin cycloaddition by Gribble, Gordon W., Barden, Timothy C.

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Partial loss of deuterium label in Wilkinson's catalyst promoted decarbonylations of deuterioaldehydes by Baldwin, John E, Barden, Timothy C, Pugh, Ruth L, Widdison, Wayne C

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Discovery of IWP-051, a Novel Orally Bioavailable Soluble Guanylate Cyclase Stimulator with Sustained and Dose-Dependent Hemodynamic Effects by Nakai, Takashi, Perl, Nicholas R, Iyengar, Rajesh R, Mermerian, Ara, Im, G-Yoon J, Lee, Thomas W-H, Rennie, Glen R, Jia, James, Renhowe, Paul A, Barden, Timothy C, Sheppeck, James E, Iyer, Karthik, Jung, Joon, Milne, G Todd, Segal, Chrissie, Long, Kimberly, Miyashiro, Joy, Bernier, Sylvie, Jacobson, Sarah, Tobin, Jenny, Shea, Courtney, Germano, Peter, Chien, Yueh-tyng, Zimmer, Daniel

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Absolute configurations, maximum rotations, and kinetics of thermal racemization of the 1-phenyl-2-deuteriocyclopropanes by Baldwin, John E, Barden, Timothy C

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Reinterpretation of two degradations of (-)-albene by Baldwin, John E, Barden, Timothy C, Cianciosi, Steven J

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Absolute stereochemistry of (-)-albene by Baldwin, John E, Barden, Timothy C

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Stereochemical kinetics of the thermal stereomutations interconverting achiral isomers of 1-phenyl-1,2,3-trideuteriocyclopropane by Baldwin, John E, Patapoff, Thomas W, Barden, Timothy C

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Total synthesis of (.+-.)-albene by Baldwin, John E, Barden, Timothy C

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