Search Results - "Bardelmeijer, H A"

Modulation of oral bioavailability of anticancer drugs: from mouse to man by Schellens, Jan H.M, Malingré, Mirte M, Kruijtzer, C.Marielle F, Bardelmeijer, H.A, van Tellingen, Olaf, Schinkel, Alfred H, Beijnen, Jos H

“…Oral bioavailability of many anticancer drugs is poor and highly variable. This is a major impediment to the development of new generation drugs in oncology,…”
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Derivatization in capillary electrophoresis by Bardelmeijer, H.A., Lingeman, H., de Ruiter, C., Underberg, W.J.M.

“…In recent years capillary electrophoresis (CE) has been developed into a versatile separation technique, next to gas and liquid chromatography (LC), well…”
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The co-solvent Cremophor EL limits absorption of orally administered paclitaxel in cancer patients by MALINGRE, M. M, SCHELLENS, J. H. M, BEIJNEN, J. H, VAN TELLINGEN, O, OUWEHAND, M, BARDELMEIJER, H. A, ROSING, H, KOOPMAN, F. J, JANSEN, S. E, SCHOT, M. E, TEN BOKKEL HUININK, W. W

“…The purpose of this study was to investigate the effect of the co-solvents Cremophor EL and polysorbate 80 on the absorption of orally administered paclitaxel…”
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Cannulation of the jugular vein in mice: a method for serial withdrawal of blood samples by Bardelmeijer, H A, Buckle, T, Ouwehand, M, Beijnen, J H, Schellens, J H M, van Tellingen, O

“…We have developed and validated a method that allows serial drawing of blood samples in freely moving mice using a cannula that is inserted via the jugular…”
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The oral route for the administration of cytotoxic drugs : strategies to increase the efficiency and consistency of drug delivery by BARDELMEIJER, H. A, VAN TELLINGEN, O, SCHELLENS, J. H. M, BEIJNEN, J. H

“…There is an increasing interest to administer cytotoxic drugs to patients by the oral route. Quality of life issues, treatment advantages and…”
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Increased Oral Bioavailability of Paclitaxel by GF120918 in Mice through Selective Modulation of P-glycoprotein by BARDELMEIJER, Heleen A, BEIJNEN, Jos H, BROUWER, Kenneth R, ROSING, Hilde, NOOIJEN, Willem J, SCHELLENS, Jan H. M, VAN TELLINGEN, Olaf

“…Previous studies in mice with disrupted mdr1a P-glycoprotein genes have shown that the oral bioavailability of paclitaxel is very low because of the presence…”
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Efficacy of novel P-glycoprotein inhibitors to increase the oral uptake of paclitaxel in mice by Bardelmeijer, Heleen A, Ouwehand, Mariët, Beijnen, Jos H, Schellens, Jan H M, van Tellingen, Olaf

“…P-glycoprotein inhibitors can increase the oral bioavailability of paclitaxel. We have now explored the mechanisms that determine the efficacy of several novel…”
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Pre-, on- and post-column derivatization in capillary electrophoresis by Bardelmeijer, H A, Waterval, J C, Lingeman, H, van't Hof, R, Bult, A, Underberg, W J

“…This survey gives a short overview of the various reagents and procedures that can be used for pre-, post- and on-column derivatization in capillary…”
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Cannulation of the jugular vein in mice by van Tellingen, Olaf, Bardelmeijer, Heleen A, Buckle, Tessa, Ouwehand, Mariet, Beijnen, Jos H, Schellens, Jan H M

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Low systemic exposure of oral docetaxel in mice resulting from extensive first-pass metabolism is boosted by ritonavir by BARDELMEIJER, Heleen A, OUWEHAND, Mariët, BUCKLE, Tessa, HUISMAN, Maarten T, SCHELLENS, Jan H. M, BEIJNEN, Jos H, VAN TELLINGEN, Olaf

“…P-glycoprotein seems to be the most important factor limiting the oral absorption of paclitaxel. We have now explored the mechanisms responsible for the low…”
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Determination of cyclosporin A in human and mouse plasma by reversed-phase high-performance liquid chromatography by Bardelmeijer, Heleen A., Ouwehand, Mariët, Beijnen, Jos H., Schellens, Jan H.M., van Tellingen, Olaf

“…An isocratic reversed-phase high-performance liquid chromatographic method with ultraviolet detection at 227 nm has been validated for the determination of…”
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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut by BARDELMEIJER, Heleen A, OUWEHAND, Mariët, MALINGRE, Mirte M, SCHELLENS, Jan H. M, BEIJNEN, Jos H, VAN TELLINGEN, Olaf

“…Recent studies in mice and patients have shown that the low oral bioavailability of paclitaxel can be increased by coadministration of P-glycoprotein blockers…”
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Metabolism of docetaxel in mice by BARDELMEIJER, Heleen A, ROELOFS, Arjan B. G. H, HILLEBRAND, Michel J. X, BEIJNEN, Jos H, SCHELLENS, Jan H. M, VAN TELLINGEN, Olaf

“…Previous studies have shown by quantification of the parent drug and the known metabolites M-1, M-2, M-3 and M-4 that the mass balance of docetaxel in mice and…”
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Metabolism of paclitaxel in mice by Bardelmeijer, Heleen A, Oomen, Ingrid A.M, Hillebrand, Michel J.X, Beijnen, Jos H, Schellens, Jan H.M, van Tellingen, Olaf

“…Previous mass balance studies in humans and mice have shown that the fecal and urinary recovery of paclitaxel and known metabolites (3′p-hydroxypaclitaxel,…”
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