Search Results - "Bardai, Farah H"

Lamin Dysfunction Mediates Neurodegeneration in Tauopathies by Frost, Bess, Bardai, Farah H., Feany, Mel B.

“…The filamentous meshwork formed by the lamin nucleoskeleton provides a scaffold for the anchoring of highly condensed heterochromatic DNA to the nuclear…”
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Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics by Bardai, Farah H, Ordonez, Dalila G, Bailey, Rachel M, Hamm, Matthew, Lewis, Jada, Feany, Mel B

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson disease. Genetics and neuropathology link Parkinson disease…”
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Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1 by Dastidar, Somasish Ghosh, Bardai, Farah H, Ma, Chi, Price, Valerie, Rawat, Varun, Verma, Pragya, Narayanan, Vinodh, D'Mello, Santosh R

“…The methyl-CpG binding protein 2 (MeCP2) is a widely expressed protein, the mutations of which cause Rett syndrome. The level of MeCP2 is highest in the brain…”
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Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3β by Bardai, Farah H., D'Mello, Santosh R.

“…Although it is well established that pharmacological inhibitors of classical histone deacetylases (HDACs) are protective in various in vivo models of…”
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Histone Deacetylase-1 (HDAC1) Is a Molecular Switch between Neuronal Survival and Death by Bardai, Farah H., Price, Valerie, Zaayman, Marcus, Wang, Lulu, D'Mello, Santosh R.

“…Both neuroprotective and neurotoxic roles have previously been described for histone deacetylase-1 (HDAC1). Here we report that HDAC1 expression is elevated in…”
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A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo by Bardai, Farah H, Wang, Liqun, Mutreja, Yamini, Yenjerla, Mythili, Gamblin, T Chris, Feany, Mel B

“…The microtubule binding protein tau is strongly implicated in multiple neurodegenerative disorders, including frontotemporal dementia and parkinsonism linked…”
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Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity by Bardai, Farah H, Verma, Pragya, Smith, Chad, Rawat, Varun, Wang, Lulu, D'Mello, Santosh R

“…Huntington's disease (HD) is caused by a polyglutamine expansion within the huntingtin (Htt) protein. Both loss of function of normal Htt and gain of a toxic…”
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Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta by Bardai, Farah H, D'Mello, Santosh R

“…Although it is well established that pharmacological inhibitors of classical histone deacetylases (HDACs) are protective in various in vivo models of…”
Get full text