Search Results - "Barclay, Ella"

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21 by Tomlinson, Ian, Houlston, Richard, Webb, Emily, Carvajal-Carmona, Luis, Broderick, Peter, Kemp, Zoe, Spain, Sarah, Penegar, Steven, Chandler, Ian, Gorman, Maggie, Wood, Wendy, Barclay, Ella, Lubbe, Steven, Martin, Lynn, Sellick, Gabrielle, Jaeger, Emma, Hubner, Richard, Wild, Ruth, Rowan, Andrew, Fielding, Sarah, Howarth, Kimberley, Silver, Andrew, Atkin, Wendy, Muir, Kenneth, Logan, Richard, Kerr, David, Johnstone, Elaine, Sieber, Oliver, Gray, Richard, Thomas, Huw, Peto, Julian, Cazier, Jean-Baptiste

“…Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to combinations of common low risk variants. We conducted a genome-wide…”
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Common genetic variants at the CRAC1 ( HMPS ) locus on chromosome 15q13.3 influence colorectal cancer risk by Tomlinson, Ian, Chandler, Ian, Tenesa, Albert, Farrington, Susan, Domingo, Enric, Martin, Lynn, Vijayakrishnan, Jayaram, Barclay, Ella, Houlston, Richard, Walther, Axel, Wood, Wendy, Gorman, Maggie, Heinimann, Karl, Broderick, Peter, Howarth, Kimberley, Thomas, Huw, Peto, Julian, Campbell, Harry, Webb, Emily, Sullivan, Kate, Penegar, Steven, Papaemmanuil, Elli, Kemp, Zoe, Kerr, David, Gray, Richard, Carvajal-Carmona, Luis, Cazier, Jean-Baptiste, Pittman, Alan, Rowan, Andrew, Lubbe, Steven, Jaeger, Emma, Dunlop, Malcolm, Spain, Sarah, Qureshi, Mobshra

“…We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on…”
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Liquid-Immersion Reprocessing Effects on Filtration Efficiency of 'Single-Use' Commercial Medical Face Masks by Everts, Richard J, Al Ghusaini, Shadha, Telfar-Barnard, Lucy, Barclay, Ella, Tan, Shaun, Jekel, Sonja, Jennings, Lance, Choi, Dong Hoon, Hilson, Dougal, Gibson, Barbara

“…Medical masks have inferior filtration efficiency and fit to filtering facepiece respirators (FFRs) but are widely used in healthcare and the community. These…”
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Adult Leydig Cell Tumors of the Testis Caused by Germline Fumarate Hydratase Mutations by Carvajal-Carmona, Luis G., Alam, N. Afrina, Pollard, Patrick J., Jones, Angela M., Barclay, Ella, Wortham, Noel, Pignatelli, Massimo, Freeman, Alex, Pomplun, Sabine, Ellis, Ian, Poulsom, Richard, El-Bahrawy, Mona A., Berney, Daniel M., Tomlinson, Ian P. M.

“…Context: Leydig cell tumors (LCTs) are the most common non-germ-cell neoplasms of the testis. LCTs are often hormonally active and can result in precocious…”
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A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk by Chandler, Ian, Teixeira, Ana, Howarth, Kimberley, Martin, Lynn, Cazier, Jean-Baptiste, Vijayakrishnan, Jayaram, Houlston, Richard S, Sieber, Oliver, Rowan, Andrew, Wood, Wendy, Tomlinson, Ian, Broderick, Peter, Carvajal-Carmona, Luis, Kemp, Zoe, Sellick, Gabrielle, Peto, Julian, Webb, Emily, Sullivan, Kate, Penegar, Steven, Papaemmanuil, Elli, Fielding, Sarah, Kerr, David, Pittman, Alan M, Barclay, Ella, Gray, Richard, Spain, Sarah, Domingo, Enric, Lubbe, Steven, Gorman, Maggie, Jaeger, Emma, Qureshi, Mobshra

“…To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with…”
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Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer by Houlston, Richard S, Webb, Emily, Broderick, Peter, Pittman, Alan M, Di Bernardo, Maria Chiara, Lubbe, Steven, Chandler, Ian, Vijayakrishnan, Jayaram, Sullivan, Kate, Penegar, Steven, Carvajal-Carmona, Luis, Howarth, Kimberley, Jaeger, Emma, Spain, Sarah L, Walther, Axel, Barclay, Ella, Martin, Lynn, Gorman, Maggie, Domingo, Enric, Teixeira, Ana S, Kerr, David, Cazier, Jean-Baptiste, Niittymäki, Iina, Tuupanen, Sari, Karhu, Auli, Aaltonen, Lauri A, Tomlinson, Ian P M, Farrington, Susan M, Tenesa, Albert, Prendergast, James G D, Barnetson, Rebecca A, Cetnarskyj, Roseanne, Porteous, Mary E, Pharoah, Paul D P, Koessler, Thibaud, Hampe, Jochen, Buch, Stephan, Schafmayer, Clemens, Tepel, Jurgen, Schreiber, Stefan, Völzke, Henry, Chang-Claude, Jenny, Hoffmeister, Michael, Brenner, Hermann, Zanke, Brent W, Montpetit, Alexandre, Hudson, Thomas J, Gallinger, Steven, Campbell, Harry, Dunlop, Malcolm G

“…Richard Houlston and colleagues identify four new susceptibility loci for colorectal cancer through a meta-analysis of genome-wide association data, followed…”
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The Nature of Networks: An Aesthetic Model for the Connected Condition by Barclay, Ella

“…This research abstracts a history of human-machine interaction to map the look, feel and sounds of a networked environment and what it is to exist within it…”
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Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis by Whiffin, Nicola, Hosking, Fay J, Farrington, Susan M, Palles, Claire, Dobbins, Sara E, Zgaga, Lina, Lloyd, Amy, Kinnersley, Ben, Gorman, Maggie, Tenesa, Albert, Broderick, Peter, Wang, Yufei, Barclay, Ella, Hayward, Caroline, Martin, Lynn, Buchanan, Daniel D, Win, Aung Ko, Hopper, John, Jenkins, Mark, Lindor, Noralane M, Newcomb, Polly A, Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Liu, Tao, Campbell, Harry, Lindblom, Annika, Houlston, Richard S, Tomlinson, Ian P, Dunlop, Malcolm G

“…To identify common variants influencing colorectal cancer (CRC) risk, we performed a meta-analysis of five genome-wide association studies, comprising 5626…”
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A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer by Al-Tassan, Nada A., Whiffin, Nicola, Hosking, Fay J., Palles, Claire, Farrington, Susan M., Dobbins, Sara E., Harris, Rebecca, Gorman, Maggie, Tenesa, Albert, Meyer, Brian F., Wakil, Salma M., Kinnersley, Ben, Campbell, Harry, Martin, Lynn, Smith, Christopher G., Idziaszczyk, Shelley, Barclay, Ella, Maughan, Timothy S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung Ko, Hopper, John, Jenkins, Mark, Lindor, Noralane M., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fred, Casey, Graham, Dunlop, Malcolm G., Tomlinson, Ian P., Cheadle, Jeremy P., Houlston, Richard S.

“…Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS…”
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A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3 by Koessler, Thibaud, Chandler, Ian, Buch, Stephan, Agúndez, Jose AG, Caldés, Trinidad, Howarth, Kimberley, Walther, Axel, Ladero, Jose M, Morreau, Hans, Giles, Graham G, Cazier, Jean-Baptiste, Castells, Antoni, Maher, Eamonn R, Wood, Wendy, Försti, Asta, Southey, Melissa C, Broderick, Peter, Hopper, John L, de la Hoya, Miguel, Webb, Emily, Wijnen, Juul T, Aaltonen, Lauri, Dunlop, Malcolm G, John, Ulrich, Fielding, Sarah, Barnetson, Rebecca A, Barclay, Ella, Martin, Lynn, Bishop, D Timothy, Tuupanen, Sari, Tenesa, Albert, Jaeger, Emma, Cheng, K K, Niittymäki, Iina, Karhu, Auli, Schreiber, Stefan, Peto, Julian, Völzke, Henry, Schafmayer, Clemens, Luk, J, Vodicka, Pavel, Vijayakrishnan, Jayaram, Carracedo, Angel, Houlston, Richard S, Tomlinson, Ian PM, Rowan, Andrew, Ruiz-Ponte, Clara, Ho, Judy WC, Kemp, Zoe, Lipton, Lara, Sullivan, Kate, Penegar, Steven, Prendergast, James GD, Carvajal-Carmona, Luis, Hampe, Jochen, Sham, Pak C, Kerr, David, Pharoah, Paul, Severi, Gianluca, Campbell, Harry, Pittman, Alan M, Gray, Richard, Castellví-Bel, Sergi, Spain, Sarah, Domingo, Enric, Hemminki, Kari, Lubbe, Steven, Thomas, Huw, van Wezel, Tom, Naccarati, Alessio, Gorman, Maggie, Lucassen, Anneke, Farrington, Susan M, Qureshi, Mobshra, Evans, D Gareth R

“…To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940…”
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Genome‐wide association study and meta‐analysis in Northern European populations replicate multiple colorectal cancer risk loci by Tanskanen, Tomas, van den Berg, Linda, Välimäki, Niko, Aavikko, Mervi, Ness‐Jensen, Eivind, Hveem, Kristian, Wettergren, Yvonne, Bexe Lindskog, Elinor, Tõnisson, Neeme, Metspalu, Andres, Silander, Kaisa, Orlando, Giulia, Law, Philip J., Tuupanen, Sari, Gylfe, Alexandra E., Hänninen, Ulrika A., Cajuso, Tatiana, Kondelin, Johanna, Sarin, Antti‐Pekka, Pukkala, Eero, Jousilahti, Pekka, Salomaa, Veikko, Ripatti, Samuli, Palotie, Aarno, Järvinen, Heikki, Renkonen‐Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Mecklin, Jukka‐Pekka, Al‐Tassan, Nada A., Palles, Claire, Martin, Lynn, Barclay, Ella, Tenesa, Albert, Farrington, Susan M., Timofeeva, Maria N., Meyer, Brian F., Wakil, Salma M., Campbell, Harry, Smith, Christopher G., Idziaszczyk, Shelley, Maughan, Tim S., Kaplan, Richard, Kerr, Rachel, Kerr, David, Buchanan, Daniel D., Win, Aung K., Hopper, John, Jenkins, Mark A., Newcomb, Polly A., Gallinger, Steve, Conti, David, Schumacher, Fredrick R., Casey, Graham, Cheadle, Jeremy P., Dunlop, Malcolm G., Tomlinson, Ian P., Houlston, Richard S., Palin, Kimmo, Aaltonen, Lauri A.

“…Genome‐wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in…”
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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer by Tomlinson, Ian P M, Alam, N Afrina, Rowan, Andrew J, Barclay, Ella, Jaeger, Emma E M, Kelsell, David, Leigh, Irene, Gorman, Patricia, Lamlum, Hanan, Rahman, Shamima, Roylance, Rebecca R, Olpin, Simon, Bevan, Stephen, Barker, Karen, Hearle, Nicholas, Houlston, Richard S, Kiuru, Maija, Lehtonen, Rainer, Karhu, Auli, Vilkki, Susa, Laiho, Päivi, Eklund, Carita, Vierimaa, Outi, Aittomäki, Kristiina, Hietala, Marja, Sistonen, Pertti, Paetau, Anders, Salovaara, Reijo, Herva, Riitta, Launonen, Virpi, Aaltonen, Lauri A

“…Uterine leiomyomata (fibroids) are common and clinically important tumors, but little is known about their etiology and pathogenesis. We previously mapped a…”
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Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome by Pollard, Patrick, Wortham, Noel, Barclay, Ella, Alam, Afrina, Elia, George, Manek, Sanjiv, Poulsom, Richard, Tomlinson, Ian

“…The Mendelian tumour syndromes hereditary leiomyomatosis and renal cell cancer (HLRCC) and hereditary paragangliomatosis with phaeochromocytomas (HPGL) result…”
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Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer by Timofeeva, Maria N., Kinnersley, Ben, Farrington, Susan M., Whiffin, Nicola, Palles, Claire, Svinti, Victoria, Lloyd, Amy, Gorman, Maggie, Ooi, Li-Yin, Hosking, Fay, Barclay, Ella, Zgaga, Lina, Dobbins, Sara, Martin, Lynn, Theodoratou, Evropi, Broderick, Peter, Tenesa, Albert, Smillie, Claire, Grimes, Graeme, Hayward, Caroline, Campbell, Archie, Porteous, David, Deary, Ian J., Harris, Sarah E., Northwood, Emma L., Barrett, Jennifer H., Smith, Gillian, Wolf, Roland, Forman, David, Morreau, Hans, Ruano, Dina, Tops, Carli, Wijnen, Juul, Schrumpf, Melanie, Boot, Arnoud, Vasen, Hans F A, Hes, Frederik J., van Wezel, Tom, Franke, Andre, Lieb, Wolgang, Schafmayer, Clemens, Hampe, Jochen, Buch, Stephan, Propping, Peter, Hemminki, Kari, Försti, Asta, Westers, Helga, Hofstra, Robert, Pinheiro, Manuela, Pinto, Carla, Teixeira, Manuel, Ruiz-Ponte, Clara, Fernández-Rozadilla, Ceres, Carracedo, Angel, Castells, Antoni, Castellví-Bel, Sergi, Campbell, Harry, Bishop, D. Timothy, Tomlinson, Ian P M, Dunlop, Malcolm G., Houlston, Richard S.

“…Whilst common genetic variation in many non-coding genomic regulatory regions are known to impart risk of colorectal cancer (CRC), much of the heritability of…”
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Carcinogenesis in MYH-associated polyposis follows a distinct genetic pathway by LIPTON, Lara, HALFORD, Sarah E, HODGSON, Shirley V, AALTONEN, Lauri A, THOMAS, Huw J. W, TOMLINSON, Ian P. M, JOHNSON, Victoria, NOVELLI, Marco R, JONES, Angela, CUMMINGS, Carole, BARCLAY, Ella, SIEBER, Oliver, SADAT, Amir, BISGAARD, Marie-Luise

“…Colorectal carcinomas develop according to particular genetic pathways, including the chromosomal instability (CIN+), microsatellite instability (MSI+) and…”
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Low penetrance breast cancer predisposition SNPs are site specific by Mcinerney, Niall, Colleran, Gabrielle, Rowan, Andrew, Walther, Axel, Barclay, Ella, Spain, Sarah, Jones, Angela M, Tuohy, Stephen, Curran, Catherine, Miller, Nicola, Kerin, Michael, Tomlinson, Ian, Sawyer, Elinor

“…Large scale association studies have identified low penetrance susceptibility alleles that predispose to breast cancer. A locus on chromosome 8q24.21 has been…”
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Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP by Cheng, Timothy H T, Gorman, Maggie, Martin, Lynn, Barclay, Ella, Casey, Graham, Saunders, Brian, Thomas, Huw, Clark, Sue, Tomlinson, Ian

“…The presence of multiple (5-100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if…”
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TGFBR16A/9A polymorphism is not associated with differential risk of breast cancer by Colleran, Gabrielle, McInerney, Niall, Rowan, Andrew, Barclay, Ella, Jones, Angela M, Curran, Catherine, Miller, Nicola, Kerin, Michael, Tomlinson, Ian, Sawyer, Elinor

“…A polymorphic 9-bp deletion in exon 1 of TGFBR1 (TGFBR1*6A) has been identified as a low-penetrance cancer susceptibility allele. The strongest association in…”
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Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer by Pittman, Alan M., Webb, Emily, Carvajal-Carmona, Luis, Howarth, Kimberley, Di Bernardo, Maria Chiara, Broderick, Peter, Spain, Sarah, Walther, Axel, Price, Amy, Sullivan, Kate, Twiss, Philip, Fielding, Sarah, Rowan, Andrew, Jaeger, Emma, Vijayakrishnan, Jayaram, Chandler, Ian, Penegar, Steven, Qureshi, Mobshra, Lubbe, Steven, Domingo, Enric, Kemp, Zoe, Barclay, Ella, Wood, Wendy, Martin, Lynn, Gorman, Maggie, Thomas, Huw, Peto, Julian, Bishop, Timothy, Gray, Richard, Maher, Eamonn R., Lucassen, Anneke, Kerr, David, Evans, Gareth R., van Wezel, Tom, Morreau, Hans, Wijnen, Juul T., Hopper, John L., Southey, Melissa C., Giles, Graham G., Severi, Gianluca, Castellví-Bel, Sergi, Ruiz-Ponte, Clara, Carracedo, Angel, Castells, Antoni, Försti, Asta, Hemminki, Kari, Vodicka, Pavel, Naccarati, Alessio, Lipton, Lara, Ho, Judy W.C., Cheng, K.K., Sham, Pak C., Luk, J., Agúndez, Jose A.G., Ladero, Jose M., de la Hoya, Miguel, Caldés, Trinidad, Niittymäki, Iina, Tuupanen, Sari, Karhu, Auli, Aaltonen, Lauri A., Cazier, Jean-Baptiste, Tomlinson, Ian P.M., Houlston, Richard S.

“…The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To…”
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Evidence for a colorectal cancer susceptibility locus on chromosome 3q21–q24 from a high-density SNP genome-wide linkage scan by Kemp, Zoe, Carvajal-Carmona, Luis, Spain, Sarah, Barclay, Ella, Gorman, Margaret, Martin, Lynn, Jaeger, Emma, Brooks, Neil, Bishop, D. Timothy, Thomas, Huw, Tomlinson, Ian, Papaemmanuil, Elli, Webb, Emily, Sellick, Gabrielle S, Wood, Wendy, Evans, Gareth, Lucassen, Anneke, Maher, Eamonn R, Houlston, Richard S

“…To identify a novel susceptibility gene for colorectal cancer (CRC), we conducted a genome-wide linkage analysis of 69 pedigrees segregating colorectal…”
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