Search Results - "Barciszewski, Jakub"

Revealing the epigenetic effect of temozolomide on glioblastoma cell lines in therapeutic conditions by Belter, Agnieszka, Barciszewski, Jakub, Barciszewska, Anna-Maria

“…Temozolomide (TMZ) is a drug of choice in glioblastoma treatment. Its therapeutic applications expand also beyond high grade gliomas. However, a significant…”
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Mechanistic Insights on Metformin and Arginine Implementation as Repurposed Drugs in Glioblastoma Treatment by Barciszewska, Anna-Maria, Belter, Agnieszka, Barciszewski, Jakub F, Gawrońska, Iwona, Giel-Pietraszuk, Małgorzata, Naskręt-Barciszewska, Mirosława Z

“…As the most common and aggressive primary malignant brain tumor, glioblastoma is still lacking a satisfactory curative approach. The standard management…”
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Identification of a Steric Zipper Motif in the Amyloidogenic Core of Human Cystatin C and Its Use for the Design of Self-Assembling Peptides by Iłowska, Emilia, Barciszewski, Jakub, Jaskólski, Mariusz, Moliński, Augustyn, Kozak, Maciej, Szymańska, Aneta

“…Amyloid fibrils have been known for many years. Unfortunately, their fame stems from negative aspects related to amyloid diseases. Nevertheless, due to their…”
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High-Resolution Crystal Structure of Muscle Phosphoglycerate Mutase Provides Insight into Its Nuclear Import and Role by Wiśniewski, Janusz, Barciszewski, Jakub, Turlik, Jakub, Baran, Karolina, Duda, Przemysław, Jaskolski, Mariusz, Rakus, Dariusz

“…Phosphoglycerate mutase (PGAM) is a glycolytic enzyme converting 3-phosphoglycerate to 2-phosphoglycerate, which in mammalian cells is expressed in two…”
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New ligand-binding sites identified in the crystal structures of β-lactoglobulin complexes with desipramine by Loch, Joanna I, Barciszewski, Jakub, Śliwiak, Joanna, Bonarek, Piotr, Wróbel, Paulina, Pokrywka, Kinga, Shabalin, Ivan G, Minor, Wladek, Jaskolski, Mariusz, Lewiński, Krzysztof

“…The homodimeric β-lactoglobulin belongs to the lipocalin family of proteins that transport a wide range of hydrophobic molecules and can be modified by…”
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Structural and biophysical studies of new l‐asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn‐amidohydrolase by Loch, Joanna I., Klonecka, Agnieszka, Kądziołka, Kinga, Bonarek, Piotr, Barciszewski, Jakub, Imiolczyk, Barbara, Brzezinski, Krzysztof, Gilski, Mirosław, Jaskolski, Mariusz

“…This work reports the results of random mutagenesis of the Escherichia coli class 2 l‐asparaginase EcAIII belonging to the Ntn‐hydrolase family. New variants…”
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T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure by Barciszewski, Jakub, Wisniewski, Janusz, Kolodziejczyk, Robert, Jaskolski, Mariusz, Rakus, Dariusz, Dzugaj, Andrzej

“…Fructose‐1,6‐bisphosphatase (FBPase) catalyzes the hydrolysis of fructose 1,6‐bisphosphate to fructose 6‐phosphate and is a key enzyme of gluconeogenesis and…”
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Enzyme engineering by random mutagenesis: structural and functional studies of modified plant-type L -asparaginase (EcAIII) by Loch, Joanna I., Klonecka, Agnieszka, Kądziołka, Kinga, Bonarek, Piotr, Barciszewski, Jakub, Lewiński, Krzysztof, Jaskolski, Mariusz

“…Abstract only…”
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Biochemical and structural insights into an unusual, alkali‐metal‐independent S‐adenosyl‐l‐homocysteine hydrolase from Synechocystis sp. PCC 6803 by Malecki, Piotr H., Imiolczyk, Barbara, Barciszewski, Jakub, Czyrko-Horczak, Justyna, Sliwiak, Joanna, Gawel, Magdalena, Wozniak, Katarzyna, Jaskolski, Mariusz, Brzezinski, Krzysztof

“…The mesophilic cyanobacterium Synechocystis sp. PCC 6803 encodes an S‐adenosyl‐l‐homocysteine hydrolase (SAHase) of archaeal origin in its genome. SAHases are…”
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Structural studies of human muscle FBPase: Human muscle FBPase by Barciszewski, Jakub, Szpotkowski, Kamil, Wisniewski, Janusz, Kolodziejczyk, Robert, Rakus, Dariusz, Jaskolski, Mariusz, Dzugaj, Andrzej

“…Muscle fructose-1,6-bisphosphatase (FBPase), which catalyzes the hydrolysis of fructose-1,6-bisphosphate (F1,6BP) to fructose-6-phosphate (F6P) and inorganic…”
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Structure of γ-conglutin: insight into the quaternary structure of 7S basic globulins from legumes by Czubinski, Jaroslaw, Barciszewski, Jakub, Gilski, Miroslaw, Szpotkowski, Kamil, Debski, Janusz, Lampart-Szczapa, Eleonora, Jaskolski, Mariusz

“…γ‐Conglutin from lupin seeds is an unusual 7S basic globulin protein. It is capable of reducing glycaemia in mammals, but the structural basis of this activity…”
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Specific binding of gibberellic acid by Cytokinin-Specific Binding Proteins: a new aspect of plant hormone-binding proteins with the PR-10 fold by Ruszkowski, Milosz, Sliwiak, Joanna, Ciesielska, Agnieszka, Barciszewski, Jakub, Sikorski, Michal, Jaskolski, Mariusz

“…Pathogenesis‐related proteins of class 10 (PR‐10) are a family of plant proteins with the same fold characterized by a large hydrophobic cavity that allows…”
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Life as a way of the functioning of matter - Theory of organic being of Jędrzej Śniadecki by Zubek, Aniela, Barciszewski, Jakub, Belter, Agnieszka, Barciszewski, Jan

“…In 2018 we celebrate the 250th anniversary of the Jędrzej Śniadecki's birth. This work aims to show the importance of his thoughts for the development of…”
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Cytochrome c6B of Synechococcus sp. WH 8102 – Crystal structure and basic properties of novel c6-like family representative by Zatwarnicki, Pawel, Barciszewski, Jakub, Krzywda, Szymon, Jaskolski, Mariusz, Kolesinski, Piotr, Szczepaniak, Andrzej

“…•Crystal structure of cytochrome c6B from Synechococcus sp. WH 8102 was solved.•Basic biophysical properties of cytochrome c6B were determined.•Cytochrome c6B…”
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Cytochrome c 6B of Synechococcus sp. WH 8102 - Crystal structure and basic properties of novel c 6-like family representative by Zatwarnicki, Pawel, Barciszewski, Jakub, Krzywda, Szymon, Jaskolski, Mariusz, Kolesinski, Piotr, Szczepaniak, Andrzej

“…Cytochromes c are soluble electron carriers of relatively low molecular weight, containing single heme moiety. In cyanobacteria cytochrome c 6 participates in…”
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Cytochrome c(6B) of Synechococcus sp. WH 8102--crystal structure and basic properties of novel c(6)-like family representative by Zatwarnicki, Pawel, Barciszewski, Jakub, Krzywda, Szymon, Jaskolski, Mariusz, Kolesinski, Piotr, Szczepaniak, Andrzej

“…Cytochromes c are soluble electron carriers of relatively low molecular weight, containing single heme moiety. In cyanobacteria cytochrome c6 participates in…”
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Structure of [gamma]-conglutin: insight into the quaternary structure of 7S basic globulins from legumes by Czubinski, Jaroslaw, Barciszewski, Jakub, Gilski, Miroslaw, Szpotkowski, Kamil, Debski, Janusz, Lampart-Szczapa, Eleonora, Jaskolski, Mariusz

“…[gamma]-Conglutin from lupin seeds is an unusual 7S basic globulin protein. It is capable of reducing glycaemia in mammals, but the structural basis of this…”
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