Search Results - "Barcia, Carlos"

Glial-Mediated Inflammation Underlying Parkinsonism by Barcia, Carlos

“…The interest in studying neuroimmune interactions is increasing in the scientific community, and for many researchers, immunity is becoming a crucial factor in…”
Get full text

Cold Atmospheric Plasma Induces ATP-Dependent Endocytosis of Nanoparticles and Synergistic U373MG Cancer Cell Death by He, Zhonglei, Liu, Kangze, Manaloto, Eline, Casey, Alan, Cribaro, George P., Byrne, Hugh J., Tian, Furong, Barcia, Carlos, Conway, Gillian E., Cullen, Patrick J., Curtin, James F.

“…Gold nanoparticles (AuNP) have potential as both diagnostic and therapeutic vehicles. However, selective targeting and uptake in cancer cells remains…”
Get full text

Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells by Conway, Gillian E., He, Zhonglei, Hutanu, Ana Lacramioara, Cribaro, George Paul, Manaloto, Eline, Casey, Alan, Traynor, Damien, Milosavljevic, Vladimir, Howe, Orla, Barcia, Carlos, Murray, James T., Cullen, Patrick J., Curtin, James F.

“…Room temperature Cold Atmospheric Plasma (CAP) has shown promising efficacy for the treatment of cancer but the exact mechanisms of action remain unclear. Both…”
Get full text

Infiltrating CTLs in Human Glioblastoma Establish Immunological Synapses with Tumorigenic Cells by Barcia, Carlos, Gómez, Aurora, Gallego-Sanchez, José M, Perez-Vallés, Ana, Castro, Maria G, Lowenstein, Pedro R, Herrero, Maria-Trinidad

“…The immunological synapse between T cells and tumor cells is believed to be important for effective tumor clearance. However, the immunological synapse has…”
Get full text

ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo by Barcia, Carlos, Ros, Carmen María, Annese, Valentina, Carrillo-de Sauvage, María Angeles, Ros-Bernal, Francisco, Gómez, Aurora, Yuste, José Enrique, Campuzano, Carmen María, de Pablos, Vicente, Fernandez-Villalba, Emiliano, Herrero, María Trinidad

“…The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical…”
Get full text

Correlation of MR-Based Metabolomics and Molecular Profiling in the Tumor Microenvironment of Temozolomide-Treated Orthotopic GL261 Glioblastoma in Mice by Zhao, Kai, Calero-Pérez, Pilar, Bopp, Miriam H A, Möschl, Vincent, Pagenstecher, Axel, Mulero-Acevedo, Marta, Vázquez, Mario, Barcia, Carlos, Arús, Carles, Nimsky, Christopher, Rusch, Tillmann, Bartsch, Jörg W, Candiota, Ana Paula

“…The tumor microenvironment in glioblastoma (GB) is considered to be "cold", i.e., the fraction of cytotoxic T cells, for instance, is low. Instead, macrophages…”
Get full text

Effects of Caloric Restriction on Spatial Object Recognition Memory, Hippocampal Neuron Loss and Neuroinflammation in Aged Rats by Portero-Tresserra, Marta, Galofré-López, Neus, Pallares, Elisabet, Gimenez-Montes, Claudia, Barcia, Carlos, Granero, Roser, Rojic-Becker, Divka, Vale-Martínez, Anna, Martí-Nicolovius, Margarita, Guillazo-Blanch, Gemma

“…Age-related neurobiological changes significantly affect hippocampal structure and function, such that the main cognitive impairments associated with aging are…”
Get full text

Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells by Conway, Gillian E, Zizyte, Deimante, Mondala, Julie Rose Mae, He, Zhonglei, Lynam, Lorna, Lecourt, Mathilde, Barcia, Carlos, Howe, Orla, Curtin, James F

“…Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. UA activates various signalling…”
Get full text

CCL2-expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo by Carrillo-de Sauvage, Maria Angeles, Gómez, Aurora, Ros, Carmen María, Ros-Bernal, Francisco, Martín, Eduardo D, Perez-Vallés, Ana, Gallego-Sanchez, José M, Fernández-Villalba, Emiliano, Barcia, Sr, Carlos, Barcia, Jr, Carlos, Herrero, Maria-Trinidad

“…CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of…”
Get full text

Three-dimensional vascular microenvironment landscape in human glioblastoma by Cribaro, George P, Saavedra-López, Elena, Romarate, Leire, Mitxitorena, Izaskun, Díaz, Laura R, Casanova, Paola V, Roig-Martínez, Meritxell, Gallego, José M, Perez-Vallés, Ana, Barcia, Carlos

“…The cellular complexity of glioblastoma microenvironments is still poorly understood. In-depth, cell-resolution tissue analyses of human material are rare but…”
Get full text

Functional anatomy of thalamus and basal ganglia by HERRERO, Maria-Trinidad, BARCIA, Carlos, MARI NAVARRO, Juana

“…THALAMUS: The human thalamus is a nuclear complex located in the diencephalon and comprising of four parts (the hypothalamus, the epythalamus, the ventral…”
Get full text

Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques by Barcia, Carlos, Ros, Carmen María, Ros-Bernal, Francisco, Gómez, Aurora, Annese, Valentina, Carrillo-de Sauvage, María Angeles, Yuste, José Enrique, Campuzano, Carmen María, de Pablos, Vicente, Fernández-Villalba, Emiliano, Herrero, María Trinidad

“…Abstract Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes…”
Get full text

The Involvement of Neuroinflammation and Kynurenine Pathway in Parkinson’s Disease by Guillemin, Gilles J., Herrero, María Trinidad, Barcia, Carlos, Zinger, Anna

“…Parkinson’s disease (PD) is a common neurodegenerative disorder characterised by loss of dopaminergic neurons and localized neuroinflammation occurring in the…”
Get full text

Imaging the microanatomy of astrocyte-T-cell interactions in immune-mediated inflammation by Barcia, Sr, Carlos, Mitxitorena, Izaskun, Carrillo-de Sauvage, María A, Gallego, José-María, Pérez-Vallés, Ana, Barcia, Jr, Carlos

“…The role of astrocytes in the immune-mediated inflammatory response in the brain is more prominent than previously thought. Astrocytes become reactive in…”
Get full text

Imbalance of immunological synapse-kinapse states reflects tumor escape to immunity in glioblastoma by Díaz, Laura R, Saavedra-López, Elena, Romarate, Leire, Mitxitorena, Izaskun, Casanova, Paola V, Cribaro, George P, Gallego, José M, Pérez-Vallés, Ana, Forteza-Vila, Jerónimo, Alfaro-Cervello, Clara, García-Verdugo, José M, Barcia, Sr, Carlos, Barcia, Jr, Carlos

“…Since the proper activation of T cells requires the physical interaction with target cells through the formation of immunological synapses (IS), an alteration…”
Get full text

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure by Barcia, Carlos, Bahillo, Angel Sánchez, Fernández-Villalba, Emiliano, Bautista, Víctor, Poza Y Poza, Máximo, Fernández-Barreiro, Andrés, Hirsch, Etienne C., Herrero, María-Trinidad

“…Inflammatory changes have been found in Parkinson's disease, in humans intoxicated with the parkinsonian toxin MPTP, and in animal models of the disease…”
Get full text

In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain by Barcia, Carlos, Thomas, Clare E, Curtin, James F, King, Gwendalyn D, Wawrowsky, Kolja, Candolfi, Marianela, Xiong, Wei-Dong, Liu, Chunyan, Kroeger, Kurt, Boyer, Olivier, Kupiec-Weglinski, Jerzy, Klatzmann, David, Castro, Maria G, Lowenstein, Pedro R

“…The microanatomy of immune clearance of infected brain cells remains poorly understood. Immunological synapses are essential anatomical structures that channel…”
Get full text

Immunology and the Central Nervous System by Barcia, Carlos, Curtin, James, Zirger, Jeffrey, Larocque, Daniel

“…In line with this, M. S. Zaborowski and Michalak describe how the appearance of paraneoplastic neurological syndromes may be linked with the certain antitumor…”
Get full text

Fms-Like Tyrosine Kinase 3 Ligand Recruits Plasmacytoid Dendritic Cells to the Brain by Curtin, James F, King, Gwendalyn D, Barcia, Carlos, Liu, Chunyan, Hubert, Francois X, Guillonneau, Carole, Josien, Regis, Anegon, Ignacio, Lowenstein, Pedro R, Castro, Maria G

“…The lack of professional afferent APCs in naive brain parenchyma contributes to the systemic immune ignorance to Ags localized exclusively within the brain…”
Get full text

T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury by Barcia, Carlos, Sanderson, Nicholas S R, Barrett, Robert J, Wawrowsky, Kolja, Kroeger, Kurt M, Puntel, Mariana, Liu, Chunyan, Castro, Maria G, Lowenstein, Pedro R

“…Astrocytes usually respond to trauma, stroke, or neurodegeneration by undergoing cellular hypertrophy, yet, their response to a specific immune attack by T…”
Get full text