Search Results - "Barchi, R L"

Nomenclature of voltage-gated sodium channels by Goldin, A L, Barchi, R L, Caldwell, J H, Hofmann, F, Howe, J R, Hunter, J C, Kallen, R G, Mandel, G, Meisler, M H, Netter, Y B, Noda, M, Tamkun, M M, Waxman, S G, Wood, J N, Catterall, W A

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Primary Structure and Functional Expression of the Human Cardiac Tetrodotoxin-Insensitive Voltage-Dependent Sodium Channel by Gellens, Mary E., George, Alfred L., Chen, Liqiong, Chahine, Mohamed, Horn, Richard, Barchi, Robert L., Kallen, Roland G.

“…The principal voltage-sensitive sodium channel from human heart has been cloned, sequenced, and functionally expressed. The cDNA, designated hH1, encodes a…”
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Loss of electrical excitability in an animal model of acute quadriplegic myopathy by Rich, M M, Pinter, M J, Kraner, S D, Barchi, R L

“…In rats treated with high-dose corticosteroids, skeletal muscle that is denervated in vivo (steroid-denervated [S-D]) develops electrical inexcitability…”
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Sodium Channel Mutations in Paramyotonia Congenita Exhibit Similar Biophysical Phenotypes In vitro by Yang, Naibo, Ji, Sen, Zhou, Ming, Ptacek, Louis J., Barchi, Robert L., Horn, Richard, George, Alfred L.

“…Mutations in the skeletal muscle voltagegated Na+channel α-subunit have been found in patients with two distinct hereditary disorders of sarcolemmal…”
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Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita by Ptácek, L J, George, Jr, A L, Barchi, R L, Griggs, R C, Riggs, J E, Robertson, M, Leppert, M F

“…The periodic paralyses are a group of autosomal dominant muscle diseases sharing a common feature of episodic paralysis. In one form, paramyotonia congenita…”
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Paramyotonia congenita and hyperkalemic periodic paralysis are linked to the adult muscle sodium channel gene by Ebers, G C, George, A L, Barchi, R L, Ting-Passador, S S, Kallen, R G, Lathrop, G M, Beckmann, J S, Hahn, A F, Brown, W F, Campbell, R D

“…The hyperkalemic periodic paralyses are a clinically heterogeneous group of autosomal dominant syndromes characterized by episodic paralysis associated with an…”
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Chimeric study of sodium channels from rat skeletal and cardiac muscle by Chen, L.-Q., Chahine, M., Kallen, R.G., Barchi, R.L., Horn, R.

“…Two isoforms of voltage-dependent Na channels, cloned from rat skeletal muscle, were expressed in Xenopus oocytes. The currents of rSkM1 and rSkM2 differ…”
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Primary structure of the adult human skeletal muscle voltage-dependent sodium channel by George, Jr, A L, Komisarof, J, Kallen, R G, Barchi, R L

“…The gene encoding the principal voltage-dependent sodium channel expressed in adult human skeletal muscle (SCN4A) has recently been linked to the pathogenesis…”
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SkM2, a Na+ channel cDNA clone from denervated skeletal muscle, encodes a tetrodotoxin-insensitive Na+ channel by White, M M, Chen, L Q, Kleinfield, R, Kallen, R G, Barchi, R L

“…Approximately one third of the Na+ channels expressed in denervated or developing skeletal muscle are tetrodotoxin (TTX) insensitive, with a Kd for channel…”
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Phenotype and genotype in the myotonic disorders by Barchi, Robert L.

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The voltage-sensitive sodium channel from rabbit skeletal muscle. Chemical characterization of subunits by Roberts, R.H., Barchi, R.L.

“…The alpha and beta subunits of the rabbit skeletal muscle sodium channel have been separated and isolated preparatively under denaturing conditions. In this…”
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Sodium channel mutations in paramyotonia congenita and hyperkalemic periodic paralysis by Ptacek, L J, Gouw, L, Kwieciński, H, McManis, P, Mendell, J R, Barohn, R J, George, Jr, A L, Barchi, R L, Robertson, M, Leppert, M F

“…Clinical and electrophysiological data have outlined a spectrum of similar yet distinct periodic paralyses, including potassium-sensitive (hyperkalemic…”
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Lidocaine block of human heart sodium channels expressed in Xenopus oocytes by Chahine, M, Chen, L Q, Barchi, R L, Kallen, R G, Horn, R

“…The tertiary amine lidocaine is used clinically for preventing cardiac arrhythmias, and has been widely studied on mammalian tissue. Xenopus oocytes were used…”
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Ion channel mutations and diseases of skeletal muscle by Barchi, R L

“…Voltage-gated ion channels play a critical role in coupling excitation at the neuromuscular junction to activation of contractile elements within a muscle…”
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Localization of sodium channel subtypes in adult rat skeletal muscle using channel-specific monoclonal antibodies by Haimovich, B, Schotland, DL, Fieles, WE, Barchi, RL

“…Five monoclonal antibodies specific for the 260 kDa subunit of the rat skeletal muscle sodium channel were used to probe the distribution of this channel in…”
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Purification and functional reconstitution of the voltage-sensitive sodium channel from rabbit T-tubular membranes by Kraner, S D, Tanaka, J C, Barchi, R L

“…The voltage-sensitive sodium channel has been purified from rabbit T-tubular membranes and reconstituted into defined phospholipid vesicles. Membranes enriched…”
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Pharmacological modulation of human cardiac Na+ channels by Krafte, D S, Davison, K, Dugrenier, N, Estep, K, Josef, K, Barchi, R L, Kallen, R G, Silver, P J, Ezrin, A M

“…Pharmacological modulation of human sodium current was examined in Xenopus oocytes expressing human heart Na+ channels. Na+ currents activated near -50 mV with…”
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Functional Reconstitution of the Purified Sodium Channel Protein from Rat Sarcolemma by Weigele, J. B., Barchi, R. L.

“…The purified saxitoxin (STX) binding component of the rat sarcolemmal sodium channel (SBC) has been reconstituted into phospholipid vesicles. The reconstituted…”
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Genomic organization of the human skeletal muscle sodium channel gene by George, Jr, A L, Iyer, G S, Kleinfield, R, Kallen, R G, Barchi, R L

“…Voltage-dependent sodium channels are essential for normal membrane excitability and contractility in adult skeletal muscle. The gene encoding the principal…”
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Immunoaffinity isolation of Na+ channels from rat skeletal muscle. Analysis of subunits by Casadei, J M, Gordon, R D, Barchi, R L

“…Polyclonal antiserum and monoclonal antibodies raised against the sodium channel from rat skeletal muscle sarcolemma have been immobilized on Sepharose and…”
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