Search Results - "Barcellos, L F"

Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children by Walsh, K M, Chokkalingam, A P, Hsu, L-I, Metayer, C, de Smith, A J, Jacobs, D I, Dahl, G V, Loh, M L, Smirnov, I V, Bartley, K, Ma, X, Wiencke, J K, Barcellos, L F, Wiemels, J L, Buffler, P A

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High consumption of coffee is associated with decreased multiple sclerosis risk; results from two independent studies by Hedström, A K, Mowry, E M, Gianfrancesco, M A, Shao, X, Schaefer, C A, Shen, L, Olsson, T, Barcellos, L F, Alfredsson, L

“…ObjectivePrevious studies on consumption of caffeine and risk of multiple sclerosis (MS) have yielded inconclusive results. We aimed to investigate whether…”
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HLA-DR2 Dose Effect on Susceptibility to Multiple Sclerosis and Influence on Disease Course by Barcellos, L.F., Oksenberg, J.R., Begovich, A.B., Martin, E.R., Schmidt, S., Vittinghoff, E., Goodin, D.S., Pelletier, D., Lincoln, R.R., Bucher, P., Swerdlin, A., Pericak-Vance, M.A., Haines, J.L., Hauser, S.L.

“…Models of disease susceptibility in multiple sclerosis (MS) often assume a dominant action for the HLA-DRB1*1501 allele and its associated haplotype (…”
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MHC associations with clinical and autoantibody manifestations in European SLE by Morris, D L, Fernando, M M A, Taylor, K E, Chung, S A, Nititham, J, Alarcón-Riquelme, M E, Barcellos, L F, Behrens, T W, Cotsapas, C, Gaffney, P M, Graham, R R, Pons-Estel, B A, Gregersen, P K, Harley, J B, Hauser, S L, Hom, G, Langefeld, C D, Noble, J A, Rioux, J D, Seldin, M F, Vyse, T J, Criswell, L A

“…Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease affecting multiple organ systems and characterized by autoantibody formation to…”
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Multiple sclerosis genetics: leaving no stone unturned by Oksenberg, J R, Barcellos, L F

“…Compelling epidemiologic and molecular data indicate that genes play a primary role in determining who is at risk for developing multiple sclerosis (MS), how…”
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Familial effects on the clinical course of multiple sclerosis by HENSIEK, A. E, SEAMAN, S. R, LEONE, M, ANDERSEN, O, BENCSIK, K, BOOTH, D, CELIUS, E. G, HARBO, H. F, HAUSER, S. L, HEARD, R, HILLERT, J, MYHR, K.-M, BARCELLOS, L. F, MARROSU, M. G, OKSENBERG, J. R, RAJDA, C, SAWCER, S. J, SØRENSEN, P. S, ZIPP, F, COMPSTON, D. A. S, OTURAI, A, ERAKSOI, M, COCCO, E, VECSEI, L, STEWART, G, DUBOIS, B, BELLMAN-STROBL, J

“…Familial factors influence susceptibility to multiple sclerosis (MS) but it is unknown whether there are additional effects on the natural history of the…”
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Men transmit MS more often to their children vs women : The Carter effect by KANTARCI, O. H, BARCELLOS, L. F, ATKINSON, E. J, RAMSAY, P. P, LINCOLN, R, ACHENBACH, S. J, DE ANDRADE, M, HAUSER, S. L, WEINSHENKER, B. G

“…Multiple sclerosis (MS) is approximately twice as common among women as men. If men have greater physiologic resistance to MS, they might theoretically require…”
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APOE epsilon variation in multiple sclerosis susceptibility and disease severity: some answers by Burwick, R. M., Ramsay, P. P., Haines, J. L., Hauser, S. L., Oksenberg, J. R., Pericak-Vance, M. A., Schmidt, S., Compston, A., Maciel, P., Santos, Monica

“…Background: Previous studies have examined the role of APOE variation in multiple sclerosis (MS), but have lacked the statistical power to detect modest…”
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Genetic basis for clinical expression in multiple sclerosis by BARCELLOS, L. F, OKSENBERG, J. R, HAUSER, S. L, GREEN, A. J, BUCHER, P, RIMMLER, J. B, SCHMIDT, S, GARCIA, M. E, LINCOLN, R. R, PERICAK-VANCE, M. A, HAINES, J. L

“…Multiple sclerosis is a clinically heterogeneous demyelinating disease and an important cause of acquired neurological disability. An underlying complex…”
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The MHC2TA -168A/G polymorphism and risk for rheumatoid arthritis: a meta-analysis of 6861 patients and 9270 controls reveals no evidence for association by Bronson, P G, Criswell, L A, Barcellos, L F

“…An association between major histocompatibility complex (MHC) genes, particularly those within the class II HLA region, and rheumatoid arthritis (RA) is well…”
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Breastfeeding is associated with reduced risk of multiple sclerosis in males, predominantly among HLA-DRB115:01 carriers by Hedström, AK, Adams, C, Shao, X, Schaefer, C, Olsson, T, Barcellos, LF, Alfredsson, L

“…Background Breastfeeding as an infant appears protective against later development of some autoimmune diseases, but research into its influence on multiple…”
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The HLA locus and multiple sclerosis in Sicily by BRASSAT, D, SALEMI, G, BARCELLOS, L. F, MCNEILL, G, PROIA, P, HAUSER, S. L, OKSENBERG, J. R, SAVETTIERI, G

“…The authors report the analysis of HLA-class II allelic heterogeneity in a well characterized multiple sclerosis (MS) Sicilian dataset. Family-based…”
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Analysis of maternal-offspring HLA compatibility, parent-of-origin and non-inherited maternal effects for the classical HLA loci in type 1 diabetes by Bronson, P.G, Ramsay, P.P, Thomson, G, Barcellos, L.F

“…Type 1 diabetes (T1D) is a complex trait for which variation in the classical human leucocyte antigen (HLA) loci within the Major Histocompatibility Complex…”
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Pharmacogenomic analysis of interferon receptor polymorphisms in multiple sclerosis by SRIRAM, U, BARCELLOS, L. F, VILLOSLADA, P, RIO, J, BARANZINI, S. E, CAILLIER, S, STILLMAN, A, HAUSER, S. L, MONTALBAN, X, OKSENBERG, J. R

“…Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system characterized by progressive neurological dysfunction. No curative…”
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A Second-Generation Genomic Screen for Multiple Sclerosis by Kenealy, S.J., Babron, M.-C., Bradford, Y., Schnetz-Boutaud, N., Haines, J.L., Rimmler, J.B., Schmidt, S., Pericak-Vance, M.A., Barcellos, L.F., Lincoln, R.R., Oksenberg, J.R., Hauser, S.L., Clanet, M., Brassat, D., Edan, G., Yaouanq, J., Semana, G., Cournu-Rebeix, I., Lyon-Caen, O., Fontaine, B.

“…Multiple sclerosis (MS) is a debilitating neuroimmunological and neurodegenerative disorder. Despite substantial evidence for polygenic inheritance of the…”
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Supervised machine learning and logistic regression identifies novel epistatic risk factors with PTPN22 for rheumatoid arthritis by Briggs, F B S, Ramsay, P P, Madden, E, Norris, J M, Holers, V M, Mikuls, T R, Sokka, T, Seldin, M F, Gregersen, P K, Criswell, L A, Barcellos, L F

“…Investigating genetic interactions (epistasis) has proven difficult despite the recent advances of both laboratory methods and statistical developments. With…”
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Osteopontin polymorphisms and disease course in multiple sclerosis by CAILLIER, S, BARCELLOS, L. F, OKSENBERG, J. R, BARANZINI, S. E, SWERDLIN, A, LINCOLN, R. R, STEINMAN, L, MARTIN, E, HAINES, J. L, PERICAK-VANCE, M, HAUSER, S. L

“…Osteopontin (OPN), also known as early T-cell activating gene (Eta-1), has been recently shown to be a critical factor in the progression of experimental…”
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Multiple sclerosis: Genomic rewards by Oksenberg, Jorge R, Baranzini, Sergio E, Barcellos, Lisa F, Hauser, Stephen L

“…A large body of immunologic, epidemiologic, and genetic data indicate that tissue inury in multiple sclerosis (MS) results from an abnormal immune response to…”
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Association Mapping of Disease Loci, by Use of a Pooled DNA Genomic Screen by Barcellos, Lisa F., Klitz, William, Field, L. Leigh, Tobias, Rose, Bowcock, Anne M., Wilson, Ross, Nelson, Mark P., Nagatomi, Jane, Thomson, Glenys

“…Genomic screening to map disease loci by association requires automation, pooling of DNA samples, and 3,000–6,000 highly polymorphic, evenly spaced…”
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Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans by Brassat, D, Motsinger, A A, Caillier, S J, Erlich, H A, Walker, K, Steiner, L L, Cree, B A C, Barcellos, L F, Pericak-Vance, M A, Schmidt, S, Gregory, S, Hauser, S L, Haines, J L, Oksenberg, J R, Ritchie, M D

“…Multiple sclerosis (MS) is a common disease of the central nervous system characterized by inflammation, myelin loss, gliosis, varying degrees of axonal…”
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