Safety and Immunogenicity of an FhSAMS Vaccine Against Fasciola hepatica in Dairy Cattle

ABSTRACT Fasciolosis is a parasitosis of great importance for livestock, as well as for public health, as it is considered by the WHO as a neglected disease. Disease control is complex and reinfections make the use of therapeutic products an unsustainable method from an economic, environmental and h...

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Published in:	Parasite immunology Vol. 46; no. 11; pp. e13074 - n/a
Main Authors:	Viana, Kelvinson Fernandes, Sperandio, Natânia do Carmo, Neto, Felipe Berbari, Donatele, Dirlei Molinari, Souza, Adrieli Barboza, Santos, Angelo Gabriel Vidal, Rivas, Açucena Veleh, Barcellos, Ema Carolina de Almeida, Martins, Isabella Vilhena Freire
Format:	Journal Article
Language:	English
Published:	Oxford Wiley Subscription Services, Inc 01-11-2024
Subjects:	Adjuvants Cattle dairy cattle Disease control Fasciola hepatica fasciolosis Immune response (humoral) Immunogenicity Livestock Lymphocytes T Parasitic diseases Public health Saponins vaccine Vaccines
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Summary:	ABSTRACT Fasciolosis is a parasitosis of great importance for livestock, as well as for public health, as it is considered by the WHO as a neglected disease. Disease control is complex and reinfections make the use of therapeutic products an unsustainable method from an economic, environmental and health point of view. The aim of this study was to evaluate a new vaccine formulation for dairy cattle, containing soluble Fasciola hepatica antigens associated with Montanide 763 AVG and saponin adjuvants (FhSAMS). The vaccine was tested with two protocols, a single dose and a booster dose 6 months after the first dose. The FhSAMS vaccine proved to be safe, with no side effects. Furthermore, it was able to generate a more robust humoral immune response when a six‐month booster dose was used, in addition to stimulating greater production of IFN‐ʏ, indicating a Th1 profile immune stimulus.
Bibliography:	Funding This study was performed with the support of the Esprito Santo Research and Support Foundation (FAPES) and Araucaria Foundation. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0141-9838 1365-3024 1365-3024
DOI:	10.1111/pim.13074