Safety of Short-Term Supplementation with Methylliberine (Dynamine ® ) Alone and in Combination with TeaCrine ® in Young Adults

Methylliberine (Dynamine ; DYM) and theacrine (Teacrine ; TCR) are purine alkaloids purported to have similar neuro-energetic effects as caffeine. There are no published human safety data on DYM, and research on TCR is limited. The purpose of this study was to examine the effect of four weeks of DYM...

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Bibliographic Details
Published in:	Nutrients Vol. 12; no. 3; p. 654
Main Authors:	VanDusseldorp, Trisha A, Stratton, Matthew T, Bailly, Alyssa R, Holmes, Alyssa J, Alesi, Michaela G, Feito, Yuri, Mangine, Gerald T, Hester, Garrett M, Esmat, Tiffany A, Barcala, Megan, Tuggle, Karleena R, Snyder, Michael, Modjeski, Andrew S
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 28-02-2020 MDPI
Subjects:	Adenosine Alanine Alanine transaminase Alkaloids Alkaloids - administration & dosage Alkaloids - adverse effects Bilirubin Biomarkers Biomarkers - blood Blood Cell Count Blood pressure Blood Pressure - drug effects Body mass Caffeine Carbon dioxide Cardiovascular system Cardiovascular System - drug effects Cardiovascular System - physiopathology Creatinine Diastole - drug effects Diet Dietary supplements Dietary Supplements - adverse effects Dosage Drug dosages Electrocardiography Eosinophils Female Glomerular filtration rate Heart rate Heart Rate - drug effects Hematology Hemoglobin High density lipoprotein Humans Laboratories Leukocytes (basophilic) Leukocytes (eosinophilic) Lipids - blood Lipoproteins Male Metabolism methylliberine Participation Physiology purine alkaloid Purines - administration & dosage Purines - adverse effects Systole - drug effects teacrine®, dynamine®, theacrine Time Factors Uric Acid - adverse effects Uric Acid - analogs & derivatives Women Young Adult Young adults purine alkaloid TeaCrine®, Dynamine®, theacrine methylliberine
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Summary:	Methylliberine (Dynamine ; DYM) and theacrine (Teacrine ; TCR) are purine alkaloids purported to have similar neuro-energetic effects as caffeine. There are no published human safety data on DYM, and research on TCR is limited. The purpose of this study was to examine the effect of four weeks of DYM supplementation with and without TCR on cardiovascular function and blood biomarkers. One-hundred twenty-five men and women (mean age 23.0 yrs, height 169.7 cm, body mass 72.1 kg; = 25/group) were randomly assigned to one of five groups: low-dose DYM (100 mg), high-dose DYM (150 mg), low-dose DYM with TCR (100 mg + 50 mg), high-dose DYM with TCR (150 mg + 25 mg) , and placebo. Regardless of group and sex, significant main effects for time were noted for heart rate, systolic blood pressure, and QTc ( < 0.001), high-density lipoproteins ( = 0.002), mean corpuscular hemoglobin ( = 0.018), basophils ( = 0.006), absolute eosinophils ( = 0.010), creatinine ( = 0.004), estimated glomerular filtration rate ( = 0.037), chloride ( = 0.030), carbon dioxide ( = 0.023), bilirubin ( = 0.027), and alanine aminotransferase ( = 0.043), among others. While small changes were found in some cardiovascular and blood biomarkers, no clinically significant changes occurred. This suggests that DYM alone or in combination with TCR consumed at the dosages used in this study does not appear to negatively affect markers of health over four weeks of continuous use.
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu12030654