Search Results - "Barbour, Robin M."

2A4 binds soluble and insoluble light chain aggregates from AL amyloidosis patients and promotes clearance of amyloid deposits by phagocytosis by Renz, Mark, Torres, Ronald, Dolan, Philip J., Tam, Stephen J., Tapia, Jose R., Li, Lauri, Salmans, Joshua R., Barbour, Robin M., Shughrue, Paul J., Nijjar, Tarlochan, Schenk, Dale, Kinney, Gene G., Zago, Wagner

“…Amyloid light chain (AL) amyloidosis is characterized by misfolded light chain (LC) (amyloid) deposition in various peripheral organs, leading to progressive…”
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Anti-Mcam Monoclonal Antibody PRX003 Inhibits the Unique Migratory Potential of Pathogenic IL-17–Producing T Cells by Flanagan, Kenneth, Tam, Stephen J, Li, Lauri, Dolan, Philip J, Barbour, Robin M, Higaki, Jeffrey N, Liu, Yue, Nijjar, Tarlochan, Skov, Michael, Zago, Wagner, Yednock, Ted A, Kinney, Gene F, Ness, Dan

“…Rationale Melanoma cell adhesion molecule (MCAM) expression on a small subset of memory CD4+/CD8+ T cells defines their ability to secrete IL-17 and identifies…”
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Immunological response to dual Aβ/Tau vaccine PRX123 surrogate and effects on brain amyloid plaques in rapidly depositing transgenic animal model by Tourino, Clara, Trumble, Alyssa, Louie, LeeAnn, Barbour, Robin M., Kinney, Gene G., Campbell, Brian, Zago, Wagner M.

“…Background Alzheimer’s disease (AD) is defined by hallmark features including Aβ plaque deposits and tau tangles throughout the brain. Clinical evidence…”
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Development of a dual Aβ‐tau vaccine for the prevention of Alzheimer’s disease by Barbour, Robin M, Bard, Frederique, Elmaarouf, Abderrahman, Louie, LeeAnn, Prill, Heather, Thomas, Kimberly, Kinney, Gene G, Zago, Wagner M

“…Background Alzheimer’s disease (AD) is characterized by two pathological hallmarks, Aβ plaques and tau tangles. Several antibodies targeting Aβ plaques showed…”
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NEOD001 Specifically Binds Aggregated Light Chain Infiltrates in Multiple Organs from Patients with AL Amyloidosis and Promotes Phagocytic Clearance of AL Aggregates in Vitro by Zago, Wagner, Renz, Mark, Torres, Ronald, Dolan, Philip J., Barbour, Robin M., Salmans, Joshua R., Shughrue, Paul J., Schenk, Dale, Kinney, Gene G.

“…Background: Light chain (AL) amyloidosis is the most common form of systemic amyloidosis and is characterized by the accumulation of aggregated, misfolded…”
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Abstract 1681: Inhibition of tumor growth in vivo through neutralization of the interaction of MCAM with laminin alpha 4 by Flanagan, Ken, Li, Lauri W., Lorenzana, Carlos, Tam, Stephen J., Liu, Yue, Dolan, Philip J., Alexander, Lana, Salmans, Josh, Barbour, Robin M., Higaki, Jeffrey N., Nijjar, Tarlochan, Zago, Wagner, Yednock, Ted A., Kinney, Gene

“…Abstract Melanoma cell adhesion molecule (MCAM/CD146) is highly expressed on a subset of many tumor types including melanoma and glioblastoma, and expression…”
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Abstract 355: A monoclonal antibody against laminin alpha 4 inhibits both MCAM and integrin-a6b1 binding, blocks tumor cell adhesion in vitro and slows melanoma tumor growth in vivo by Tam, Stephen J., Li, Lauri E., Lorenzana, Carlos, Liu, Yue, Flanagan, Ken, Dolan, Philip J., Alexander, Lana, Salmans, Josh, Barbour, Robin M., Higaki, Jeffrey N., Nijjar, Tarlochan, Zago, Wagner, Yednock, Ted A., Kinney, Gene

“…Abstract Laminin is an extracellular matrix molecule that is secreted as a trimeric protein composed of an α, β and γ chain. There are five distinct laminin α…”
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Analysis and quantitation of the beta-amyloid precursor protein in the cerebrospinal fluid of Alzheimer's disease patients with a monoclonal antibody-based immunoassay by Henriksson, T, Barbour, R M, Braa, S, Ward, P, Fritz, L C, Johnson-Wood, K, Chung, H D, Burke, W, Reinikainen, K J, Riekkinen, P

“…One of the major clinical findings in Alzheimer's disease (AD) is the formation of deposits of beta-amyloid protein in amyloid plaques, derived from the…”
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