Diagnosis of renal allograft rejection and acute tubular necrosis by 99mTc-mononuclear leukocyte imaging

Diagnosis of renal allograft rejection and acute tubular necrosis by 99mTc-mononuclear leukocyte imaging

One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. We have developed a quantitative method to diagnose rejection and acute tubular necrosis (ATN) by comparing regions of interest drawn on allograft scinti...

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Bibliographic Details
Published in:Transplantation proceedings Vol. 36; no. 10; pp. 2997 - 3001
Main Authors: Lopes de Souza, S.A., Barbosa da Fonseca, L.M., Torres Gonçalves, R., Salomão Pontes, D., Holzer, T.J., Proença Martins, F.P., Gutfilen, B.
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-12-2004
Elsevier Science
Subjects:
Acute Disease
Biological and medical sciences
Biological Transport
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Graft Rejection - diagnostic imaging
Graft Rejection - pathology
Humans
Kidney Transplantation - pathology
Kidney Tubules - pathology
Living Donors
Male
Medical sciences
Necrosis
Radionuclide Imaging
Reproducibility of Results
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technetium - pharmacokinetics
Tissue Donors
Tissue, organ and graft immunology
Transplantation, Homologous - pathology
Graft(material)
Leukocyte
Transplantation
Homotransplantation
Kidney
Medicine
Rejection
Acute tubular necrosis
Renal tubule
Treatment
Urinary system
Surgery
Graft
Medical imagery
Diagnosis
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Summary:One hundred kidney transplant recipients were evaluated on the first and fifth days after transplantation by Tc-99m mononuclear cell scintigraphy. We have developed a quantitative method to diagnose rejection and acute tubular necrosis (ATN) by comparing regions of interest drawn on allograft scintigraphs at different times after endovenous administration of the labeled cells. We suggest that the use of Tc-99m-WBC may be useful for the early diagnosis of rejection and the differential diagnosis of ATN.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.11.100