Search Results - "Barbosa, Leandro R.S"

The Importance of Protein-Protein Interactions on the pH-Induced Conformational Changes of Bovine Serum Albumin: A Small-Angle X-Ray Scattering Study by Barbosa, Leandro R.S., Ortore, Maria Grazia, Spinozzi, Francesco, Mariani, Paolo, Bernstorff, Sigrid, Itri, Rosangela

“…The combined effects of concentration and pH on the conformational states of bovine serum albumin (BSA) are investigated by small-angle x-ray scattering. Serum…”
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Trifluoperazine effects on anionic and zwitterionic micelles: a study by small angle X-ray scattering by Caetano, Wilker, Barbosa, Leandro R.S, Itri, Rosangela, Tabak, Marcel

“…In this work small angle X-ray scattering (SAXS) studies on the interaction of the phenothiazine trifluoperazine (TFP, 2–10 mM), a cationic drug, with micelles…”
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Fibrinogen stability under surfactant interaction by Hassan, Natalia, Barbosa, Leandro R.S., Itri, Rosangela, Ruso, Juan M.

“…The SAXS curves are compatible to the scattering of paired-dimers, arrangement of two fibrinogen dimmers, in this studied concentration range. [Display…”
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Identification of two p23 co‐chaperone isoforms in Leishmania braziliensis exhibiting similar structures and Hsp90 interaction properties despite divergent stabilities by Batista, Fernanda A.H, Almeida, Glessler S, Seraphim, Thiago V, Silva, Kelly P, Murta, Silvane M.F, Barbosa, Leandro R.S, Borges, Júlio C

“…The small acidic protein called p23 acts as a co‐chaperone for heat‐shock protein of 90 kDa (Hsp90) during its ATPase cycle. p23 proteins inhibit Hsp90 ATPase…”
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Sorafenib as an Inhibitor of RUVBL2 by Nano, Nardin, Ugwu, Francisca, Seraphim, Thiago V, Li, Tangzhi, Azer, Gina, Isaac, Methvin, Prakesch, Michael, Barbosa, Leandro R S, Ramos, Carlos H I, Datti, Alessandro, Houry, Walid A

“…RUVBL1 and RUVBL2 are highly conserved ATPases that belong to the AAA+ (ATPases Associated with various cellular Activities) superfamily and are involved in…”
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Impact of Monovalent and Divalent Cations on the Colloidal Stability of Negatively Charged Latex Particles Decorated with Poly(ethylene glycol) by Nukui, Larissa H. N, Barbosa, Leandro R. S, Petri, Denise F. S

“…The present work reports results from the interactions of monovalent (Na+, NH4 +, and K+) and divalent (Ca2+ and Sr2+) cations, nitrate was the counterion,…”
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Urea, Guanidine Hydrocloride and 2,2,2-Trifluoroethanol Can Change the Amyloid Fibril Formation of Model Proteins: A Spectroscopic Study by Barbosa, Leandro R.S.

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Small-angle scattering from flat bilayers containing correlated scattering length density inhomogeneities by Spinozzi, Francesco, Barbosa, Leandro R. S., Corucci, Giacomo, Mariani, Paolo, Itri, Rosangela

“…Model lipid bilayers have been widely employed as a minimal system to investigate the structural properties of biological membranes by small-angle X-ray (SAXS)…”
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Influence of hexadecylphosphocholine (Miltefosine) in phytantriol-based cubosomes: A structural investigation by Malheiros, Barbara, de Castro, Raphael Dias, Lotierzo, Mayra C., Casadei, Bruna R., Mariani, Paolo, Barbosa, Leandro R.S.

“…Miltefosine (hexadecylphosphocholine, HePC) is a broad spectrum antimicrobial, anti-leishmanial drug, originally developed as anti-cancer agent. Because of its…”
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Bacterial killing via a type IV secretion system by Souza, Diorge P., Oka, Gabriel U., Alvarez-Martinez, Cristina E., Bisson-Filho, Alexandre W., Dunger, German, Hobeika, Lise, Cavalcante, Nayara S., Alegria, Marcos C., Barbosa, Leandro R.S., Salinas, Roberto K., Guzzo, Cristiane R., Farah, Chuck S.

“…Type IV secretion systems (T4SSs) are multiprotein complexes that transport effector proteins and protein–DNA complexes through bacterial membranes to the…”
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On the Interaction of Alkyl-Functionalized Ionic Liquids with Model Proteins: A Spectroscopic and Structural Study by Raw, Juliana, Melo, Luma O., Barbosa, Leandro R.S.

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Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death by Wong, Keith S, Mabanglo, Mark F, Seraphim, Thiago V, Mollica, Antonio, Mao, Yu-Qian, Rizzolo, Kamran, Leung, Elisa, Moutaoufik, Mohamed T, Hoell, Larissa, Phanse, Sadhna, Goodreid, Jordan, Barbosa, Leandro R S, Ramos, Carlos H I, Babu, Mohan, Mennella, Vito, Batey, Robert A, Schimmer, Aaron D, Houry, Walid A

“…Acyldepsipeptides (ADEPs) are potential antibiotics that dysregulate the activity of the highly conserved tetradecameric bacterial ClpP protease, leading to…”
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Targeting intracellular Leishmania (L.) infantum with nitazoxanide entrapped into phosphatidylserine-nanoliposomes: An experimental study by Pinto, Erika Gracielle, Barbosa, Leandro R.S., Mortara, Renato A., Tempone, Andre Gustavo

“…Leishmaniasis is a parasitic neglected tropical disease and result in a broad spectrum of clinical manifestations, ranging from a single ulceration to a…”
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Repurposing doxycycline for synucleinopathies: remodelling of α-synuclein oligomers towards non-toxic parallel beta-sheet structured species by González-Lizárraga, Florencia, Socías, Sergio B., Ávila, César L., Torres-Bugeau, Clarisa M., Barbosa, Leandro R. S., Binolfi, Andres, Sepúlveda-Díaz, Julia E., Del-Bel, Elaine, Fernandez, Claudio O., Papy-Garcia, Dulce, Itri, Rosangela, Raisman-Vozari, Rita, Chehín, Rosana N.

“…Synucleinophaties are progressive neurodegenerative disorders with no cure to date. An attractive strategy to tackle this problem is repurposing already tested…”
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Enhancing the anti-psoriatic activity of vitamin D3 employing nanostructured archaeolipid carriers by Simioni, Yamila Roxana, Perez, Noelia Soledad, Barbosa, Leandro R.S., Perez, Ana Paula, Schilrreff, Priscila, Romero, Eder Lilia, Morilla, Maria Jose

“…Psoriasis (Ps) is a multifactorial autoimmune skin disease, where oxidative stress plays a key role in promoting a vicious producing cycle between…”
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Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes by Seraphim, Thiago V., Nano, Nardin, Cheung, Yiu Wing Sunny, Aluksanasuwan, Siripat, Colleti, Carolina, Mao, Yu-Qian, Bhandari, Vaibhav, Young, Gavin, Höll, Larissa, Phanse, Sadhna, Gordiyenko, Yuliya, Southworth, Daniel R., Robinson, Carol V., Thongboonkerd, Visith, Gava, Lisandra M., Borges, Júlio C., Babu, Mohan, Barbosa, Leandro R.S., Ramos, Carlos H.I., Kukura, Philipp, Houry, Walid A.

“…R2TP is a highly conserved chaperone complex formed by two AAA+ ATPases, RUVBL1 and RUVBL2, that associate with PIH1D1 and RPAP3 proteins. R2TP acts in…”
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Unveiling Sticholysin II and plasmid DNA interaction: Implications for developing non-viral vectors by Escalona-Rodriguez, Felipe A, Cruz-Leal, Yoelys, La O-Bonet, Javier, Pérez-Erviti, Julio A, Valdés-Tresanco, Mario Ernesto, Rivero-Hernández, Ada L, Sifontes-Niebla, Maricary, Manso-Vargas, Alexis, Sánchez, Belinda, Alvarez, Carlos, Barbosa, Leandro R S, Itri, Rosangela, Lanio, María E

“…Non-viral gene delivery systems offer significant potential for gene therapy due to their versatility, safety, and cost advantages over viral vectors. However,…”
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Electron Paramagnetic Resonance and Small-Angle X‑ray Scattering Characterization of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Dibucaine Encapsulation by Barbosa, Raquel M, Casadei, Bruna R, Duarte, Evandro L, Severino, Patrícia, Barbosa, Leandro R. S, Duran, Nelson, de Paula, Eneida

“…Dibucaine (DBC) is one of the most potent long-acting local anesthetics, but it also has significant toxic side effects and low water solubility. Solid lipid…”
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The Influence of Both Urea and 2,2,2-Trifluoroethanol in the Amyloid Fibril Formation of Bovine Serum Albumin by Brito, Lenilson T., Barbosa, Leandro R.S.

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Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities by Silva, Noeli S.M., Bertolino-Reis, Dayane E., Dores-Silva, Paulo R., Anneta, Fátima B., Seraphim, Thiago V., Barbosa, Leandro R.S., Borges, Júlio C.

“…HOP is a cochaperone belonging to the foldosome, a system formed by the cytoplasmic Hsp70 and Hsp90 chaperones. HOP acts as an adapter protein capable of…”
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