Search Results - "Barbosa, Helena C"

The bile acid TUDCA and neurodegenerative disorders: An overview by Zangerolamo, Lucas, Vettorazzi, Jean F., Rosa, Lucas R.O., Carneiro, Everardo M., Barbosa, Helena C.L.

“…Bear bile has been used in Traditional Chinese Medicine for thousands of years due to its therapeutic potential and clinical applications. The…”
Get full text

ARHGAP21 as a master regulator of multiple cellular processes by Rosa, Lucas R. O., Soares, Gabriela M., Silveira, Leonardo R., Boschero, Antonio C., Barbosa‐Sampaio, Helena C. L.

“…The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the…”
Get full text

Reduced glucose‐induced insulin secretion in low‐protein‐fed rats is associated with altered pancreatic islets redox status by Cappelli, Ana Paula G., Zoppi, Claudio C., Silveira, Leonardo R., Batista, Thiago M., Paula, Flávia M., da Silva, Priscilla M. R., Rafacho, Alex, Barbosa‐Sampaio, Helena C., Boschero, Antonio C., Carneiro, Everardo M.

“…In the present study, we investigated the relationship between early life protein malnutrition‐induced redox imbalance, and reduced glucose‐stimulated insulin…”
Get full text

Whole body ARHGAP21 reduction improves glucose homeostasis in high‐fat diet obese mice by Soares, Gabriela M., Zangerolamo, Lucas, Azevedo, Elis G., Costa‐Júnior, Jose M., Carneiro, Everardo M., Saad, Sara T., Boschero, Antonio C., Barbosa‐Sampaio, Helena C.

“…GTPase activating proteins (GAPs) are ubiquitously expressed, and their role in cellular adhesion and membrane traffic processes have been well described…”
Get full text

ARHGAP21 Acts as an Inhibitor of the Glucose-Stimulated Insulin Secretion Process by Ferreira, Sandra M, Costa-Júnior, José M, Kurauti, Mirian A, Leite, Nayara C, Ortis, Fernanda, Rezende, Luiz F, Barbosa, Helena C, Boschero, Antonio C, Santos, Gustavo J

“…ARHGAP21 is a RhoGAP protein implicated in the modulation of insulin secretion and energy metabolism. ARHGAP21 transient-inhibition increase glucose-stimulated…”
Get full text

Endocrine FGFs and their signaling in the brain: Relevance for energy homeostasis by Zangerolamo, Lucas, Carvalho, Marina, Velloso, Licio A, Barbosa, Helena C L

“…Since their discovery in 2000, there has been a continuous expansion of studies investigating the physiology, biochemistry, and pharmacology of endocrine…”
Get full text

Requirement of NF-kappaB signalling pathway for modulation of the cholinergic muscarinic M3 receptor expression by INGAP-PP in insulin-producing cells by PAULA, Flavia M. M, BARBOSA, Helena C. L, CARNEIRO, Everardo M, PERSAUD, Shanta J, GAGLIARDINO, Juan J, BOSCHERO, Antonio C, SOUZA, Kleber L. A

“…The pentadecapeptide comprising the 104-118 amino acid sequence of the ilotropin-derived Reg3-related islet neogenesis-associated protein (INGAP-PP) has been…”
Get full text

The bile acid TUDCA improves glucose metabolism in streptozotocin-induced Alzheimer's disease mice model by Zangerolamo, Lucas, Vettorazzi, Jean F., Solon, Carina, Bronczek, Gabriela A., Engel, Daiane F., Kurauti, Mirian A., Soares, Gabriela M., Rodrigues, Karina S., Velloso, Licio A., Boschero, Antonio C., Carneiro, Everardo M., Barbosa, Helena C.L.

“…Alzheimer's disease (AD) is a neurodegenerative disorder and the major cause of dementia. According to predictions of the World Health Organization, more than…”
Get full text

Islet neogenesis-associated protein signaling in neonatal pancreatic rat islets: involvement of the cholinergic pathway by Barbosa, Helena C, Bordin, Silvana, Anhê, Gabriel, Persaud, Shanta J, Bowe, James, Borelli, Maria I, Gagliardino, Juan J, Boschero, Antonio C

“…Islet neogenesis associated protein (INGAP) increases islet mass and insulin secretion in neonatal and adult rat islets. In the present study, we measured the…”
Get full text

Nupr1 deletion protects against glucose intolerance by increasing beta cell mass by Barbosa-Sampaio, Helena C., Liu, Bo, Drynda, Robert, Rodriguez de Ledesma, Ana M., King, Aileen J., Bowe, James E., Malicet, Cédric, Iovanna, Juan L., Jones, Peter M., Persaud, Shanta J., Muller, Dany S.

“…Aims/hypothesis The stress-activated nuclear protein transcription regulator 1 (NUPR1) is induced in response to glucose and TNF-α, both of which are elevated…”
Get full text

Development and evaluation of the active learning game "Who Am I?-Cellular Signal Transduction Edition": the positive impact on undergraduate education by de Oliveira, Kênia M, Fernandes, Ana Clara de G, Soares, Gabriela M, da Silva, Jr, Joel Alves, Carneiro, Everardo M, Barbosa, Helena C L

“…The teaching of physiology plays a crucial role in the education of health care professionals. However, traditional approaches to physiology classes in…”
Get full text

Effects of growth hormone-releasing hormone agonistic analog MR-409 on insulin-secreting cells under cyclopiazonic acid-induced endoplasmic reticulum stress by Rodrigues-dos-Santos, Karina, Soares, Gabriela M., Guimarães, Dimitrius S.P.S.F., Araújo, Thiago R., Vettorazzi, Jean F., Zangerolamo, Lucas, Marconato-Júnior, Emilio, Cai, Renzhi, Sha, Wei, Schally, Andrew V., Boschero, Antônio C., Barbosa, Helena C.L.

“…The endoplasmic reticulum (ER) stress is one of the mechanisms related to decreased insulin secretion and beta cell death, contributing to the progress of type…”
Get full text

Taurine-induced insulin signalling improvement of obese malnourished mice is associated with redox balance and protein phosphatases activity modulation by Cappelli, Ana P., Zoppi, Claudio C., Barbosa-Sampaio, Helena C., Costa -Jr, José M., Protzek, André O., Morato, Priscila N., Boschero, Antonio C., Carneiro, Everardo M.

“…Background & Aims Obese protein malnourished mice display liver insulin resistance and taurine (TAU) seems to attenuate this effect. The association between…”
Get full text

Reduced AMPKα2 protein expression restores glucose‐induced insulin secretion in islets from calorie‐restricted rats by Amaral, Maria Esméria C., Ribeiro, Rosane A., Vanzela, Emerielle C., Barbosa‐Sampaio, Helena C.

“…Summary In a state of caloric restriction (CR), improved insulin action was associated with the activation of AMP‐activated kinase (AMPK). Here, we verified…”
Get full text

Reduced insulin secretion and glucose intolerance are involved in the fasting susceptibility of common vampire bats by Freitas, Mariella B, Queiroz, Joicy F, Dias Gomes, Carolinne I, Collares-Buzato, Carla B, Barbosa, Helena C, Boschero, Antonio C, Gonçalves, Carlos A, Pinheiro, Eliana C

“…Highlights ► Reduced insulinemia and insulin secretion impairment in Desmodus rotundus . ► Irregular and small pancreatic islets, with reduced β-cell mass,…”
Get full text

Tumor necrosis factor‐α activates signal transduction in hypothalamus and modulates the expression of pro‐inflammatory proteins and orexigenic/anorexigenic neurotransmitters by Amaral, Maria E., Barbuio, Raquel, Milanski, Marciane, Romanatto, Talita, Barbosa, Helena C., Nadruz, Wilson, Bertolo, Manoel B., Boschero, Antonio C., Saad, Mario J. A., Franchini, Kleber G., Velloso, Licio A.

“…Tumor necrosis factor‐α (TNF‐α) is known to participate in the wastage syndrome that accompanies cancer and severe infectious diseases. More recently, a role…”
Get full text

Reduced expression of SIRT1 is associated with diminished glucose-induced insulin secretion in islets from calorie-restricted rats by do Amaral, Maria Esméria Corezola, Ueno, Mirian, Oliveira, Camila A.M, Borsonello, Natália C, Vanzela, Emerielle C, Ribeiro, Rosane A, Alves, Patricia L, Barbosa, Helena C, Carneiro, Everardo M, Boschero, Antonio C

“…Alterations in food intake such as caloric restriction modulate the expression of SIRT1 and SIRT4 proteins that are involved in pancreatic β-cell function…”
Get full text

Islet neogenesis-associated protein pentadecapeptide (INGAP-PP): Mechanisms involved in its effect upon β-cell mass and function by Madrid, Viviana, Del Zotto, Héctor, Maiztegui, Bárbara, Raschia, María A., Alzugaray, María E., Boschero, Antonio C., Barbosa, Helena C., Flores, Luis E., Borelli, María I., Gagliardino, Juan J.

“…The effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) administration to normal male hamsters upon serum glucose and triglyceride…”
Get full text

INGAP-PP up-regulates the expression of genes and proteins related to K+ATP channels and ameliorates Ca2+ handling in cultured adult rat islets by SILVA, Kelly E, BARBOSA, Helena C, RAFACHO, Alex, BOSQUEIRO, José R, STOPPIGLIA, Luiz F, CARNEIRO, Everardo M, BORELLI, Maria I, DEL ZOTTO, Hector, GAGLIARDINO, Juan J, BOSCHERO, Antonio C

“…Islet Neogenesis Associated Protein (INGAP) increases pancreatic beta-cell mass and potentiates glucose-induced insulin secretion. Here, we investigated the…”
Get full text

Role of Islet Glucokinase, Glucose Metabolism, and Insulin Pathway in the Enhancing Effect of Islet Neogenesis-Associated Protein on Glucose-Induced Insulin Secretion by Maiztegui, Bárbara, Román, Carolina L, Barbosa-Sampaio, Helena C, Boschero, Antonio C, Gagliardino, Juan J

“…To demonstrate the role of islet glucokinase, glucose metabolism, and intracellular insulin mediators in the enhancing effect of islet neogenesis-associated…”
Get full text