Search Results - "Barbosa, Arménio J. M"

Comparative Analysis of Pharmacophore Screening Tools by Sanders, Marijn P. A, Barbosa, Arménio J. M, Zarzycka, Barbara, Nicolaes, Gerry A.F, Klomp, Jan P.G, de Vlieg, Jacob, Del Rio, Alberto

“…The pharmacophore concept is of central importance in computer-aided drug design (CADD) mainly because of its successful application in medicinal chemistry…”
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Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity by Pina, Ana S, Morgado, Leonor, Duncan, Krystyna L, Carvalho, Sara, Carvalho, Henrique F, Barbosa, Arménio J. M, de Mariz, Beatriz, Moreira, Inês P, Kalafatovic, Daniela, Morais Faustino, Bruno M, Narang, Vishal, Wang, Tong, Pappas, Charalampos G, Ferreira, Isabel, Roque, A. Cecília A, Ulijn, Rein V

“…We demonstrate phage-display screening on self-assembled ligands that enables the identification of oligopeptides that selectively bind dynamic supramolecular…”
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Inhibition of human dyskerin as a new approach to target ribosome biogenesis by Rocchi, Laura, Barbosa, Arménio J M, Onofrillo, Carmine, Del Rio, Alberto, Montanaro, Lorenzo

“…The product of the DKC1 gene, dyskerin, is required for both ribosome biogenesis and telomerase complex stabilization. Targeting these cellular processes has…”
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Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking by Giancristofaro, Antonella, Barbosa, Arménio J. M, Ammazzalorso, Alessandra, Amoia, Pasquale, De Filippis, Barbara, Fantacuzzi, Marialuigia, Giampietro, Letizia, Maccallini, Cristina, Amoroso, Rosa

“…FXR is a member of the nuclear receptor superfamily, which regulates the expression of various genes involved in bile acid, lipid and glucose metabolism…”
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Free Marine Natural Products Databases for Biotechnology and Bioengineering by Barbosa, Arménio J. M., Roque, Ana C. A.

“…Marine organisms and micro‐organisms are a source of natural compounds with unique chemical features. These chemical properties are useful for the discovery of…”
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Native, engineered and de novo designed ligands targeting the SARS-CoV-2 spike protein by Costa, Carlos F.S., Barbosa, Arménio J.M., Dias, Ana Margarida G.C., Roque, Ana Cecília A.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the deadly coronavirus disease 2019 (Covid-19) and is a concerning hazard…”
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Integration of Molecular Dynamics Based Predictions into the Optimization of De Novo Protein Designs: Limitations and Benefits by Carvalho, Henrique F, Barbosa, Arménio J M, Roque, Ana C A, Iranzo, Olga, Branco, Ricardo J F

“…Recent advances in de novo protein design have gained considerable insight from the intrinsic dynamics of proteins, based on the integration of molecular…”
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Protein- and Peptide-Based Biosensors in Artificial Olfaction by Barbosa, Arménio J.M., Oliveira, Ana Rita, Roque, Ana C.A.

“…Animals’ olfactory systems rely on proteins, olfactory receptors (ORs) and odorant-binding proteins (OBPs), as their native sensing units to detect odours…”
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Designed affinity ligands to capture human serum albumin by dos Santos, Raquel, Figueiredo, Carina, Viecinski, Aline Canani, Pina, Ana Sofia, Barbosa, Arménio J.M., Roque, A. Cecília A.

“…•Rational design of triazine ligands for human serum albumin purification.•Mild binding and recovery with 98% purity and 100% yield.•Binding between human…”
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An odorant-binding protein based electrical sensor to detect volatile organic compounds by Teixeira, Gonçalo D.G., Esteves, Carina, Moro, Artur J., Lima, João C., Barbosa, Arménio J.M., Roque, Ana Cecília A.

“…Artificial olfaction systems, such as electronic nose devices (ENs), can be used in various fields, from healthcare to food industry and the environmental…”
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