Mitochondrial DNA Control Region Polymorphism in the Population of Alagoas State, North-Eastern Brazil

: The sequences of the two hypervariable (HV) segments of the mitochondrial DNA (mtDNA) control region were determined in 167 randomly selected, unrelated individuals living in the state of Alagoas, north‐eastern Brazil. One hundred and forty‐five different haplotypes, associated with 139 variable p...

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Bibliographic Details
Published in:	Journal of forensic sciences Vol. 53; no. 1; pp. 142 - 146
Main Authors:	Barbosa, Adriana B.G., Silva, Luiz Antonio F. da, Azevedo, Dalmo A., Balbino, Valdir Q., Mauricio-da-Silva, Luiz
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-01-2008 Wiley Subscription Services, Inc
Subjects:	Alagoas state Brazil Complementarity Determining Regions - genetics DNA Fingerprinting DNA typing DNA, Mitochondrial - genetics Ethnic Groups - genetics forensic science Genetic diversity Genetics, Population haplogroups Haplotypes Humans hypervariable regions Mitochondrial DNA Mutation Polymerase Chain Reaction Polymorphism Polymorphism, Genetic Population genetics Sequence Analysis, DNA Brazil Alagoas Brazil
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Summary:	: The sequences of the two hypervariable (HV) segments of the mitochondrial DNA (mtDNA) control region were determined in 167 randomly selected, unrelated individuals living in the state of Alagoas, north‐eastern Brazil. One hundred and forty‐five different haplotypes, associated with 139 variable positions, were determined. More than 95% of the mtDNA sequences could be allocated to specific mtDNA haplogroups according to the mutational motifs. Length heteroplasmy in the C‐stretch HV1 and HV2 regions was observed in 22 and 11%, respectively, of the population sample. The genetic diversity was estimated to be 0.9975 and the probability of two random individuals presenting identical mtDNA haplotypes was 0.0084. The most frequent haplotype was shared by six individuals. All sequences showed high‐quality values and phantom mutations were not detected. The diversity revealed in the mitochondrial control region indicates the importance of this locus for forensic casework and population studies within Alagoas, Brazil.
Bibliography:	ark:/67375/WNG-S0BT9Z18-L istex:38322CF5DC39E3DF0842F92917C51F52D1CBA939 ArticleID:JFO619 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0022-1198 1556-4029
DOI:	10.1111/j.1556-4029.2007.00619.x