Search Results - "Barboiu, Mihail"
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Encapsulation versus Self-Aggregation toward Highly Selective Artificial K+ Channels
Published in Accounts of chemical research (20-11-2018)“…Conspectus Natural ion-channel proteins allow ion transport across cell membranes at rates very close to those for ionic diffusion in water. Among them,…”
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Artificial water channels--incipient innovative developments
Published in Chemical communications (Cambridge, England) (01-01-2016)“…Aquaporins (AQPs) are biological water channels known for fast water transport (∼10(8)-10(9) water molecules per s per channel), with complete proton/ion…”
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Highly Selective Artificial K+ Channels: An Example of Selectivity-Induced Transmembrane Potential
Published in Journal of the American Chemical Society (13-01-2016)“…Natural KcsA K+ channels conduct at high rates with an extraordinary selectivity for K+ cations, excluding the Na+ or other cations. Biomimetic artificial…”
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Self‐Assembled Artificial Ion‐Channels toward Natural Selection of Functions
Published in Angewandte Chemie International Edition (11-01-2021)“…Owing to their significant physiological functions, especially as selective relays for translocation of physiological relevant species through cellular…”
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Biomimetic artificial water channel membranes for enhanced desalination
Published in Nature nanotechnology (01-02-2021)“…Inspired by biological proteins, artificial water channels (AWCs) can be used to overcome the performances of traditional desalination membranes. Their…”
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Artificial Water Channels: Towards Biomimetic Membranes for Desalination
Published in Chemistry : a European journal (01-02-2021)“…Natural Aquaporin (AQP) channels are efficient water translocating proteins, rejecting ions. Inspired by this masterpiece of nature, Artificial Water Channels…”
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Biomimetic Approach for Highly Selective Artificial Water Channels Based on Tubular Pillar[5]arene Dimers
Published in Angewandte Chemie International Edition (14-12-2020)“…Artificial water channels mimicking natural aquaporins (AQPs) can be used for selective and fast transport of water. Here, we quantify the transport…”
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Controlled Folding, Motional, and Constitutional Dynamic Processes of Polyheterocyclic Molecular Strands
Published in Angewandte Chemie International Edition (18-03-2016)“…General design principles have been developed for the control of the structural features of polyheterocyclic strands and their effector‐modulated shape…”
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Highly Selective Artificial Cholesteryl Crown Ether K+-Channels
Published in Angewandte Chemie International Edition (23-11-2015)“…The bacterial KcsA channel conducts K+ cations at high rates while excluding Na+ cations. Herein, we report an artificial ion‐channel formed by H‐bonded stacks…”
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Light-Driven Molecular Motors Boost the Selective Transport of Alkali Metal Ions through Phospholipid Bilayers
Published in Journal of the American Chemical Society (29-09-2021)“…A hydrophobic light-driven rotary motor is functionalized with two 18-crown-6 macrocycles and incorporated into phospholipid bilayers. In the presence of this…”
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A Voltage‐Responsive Synthetic Cl−‐Channel Regulated by pH
Published in Angewandte Chemie International Edition (19-10-2020)“…Transmembrane protein channels are an important inspiration for the design of artificial ion channels. Their dipolar structure helps overcome the high energy…”
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Salt-Excluding Artificial Water Channels Exhibiting Enhanced Dipolar Water and Proton Translocation
Published in Journal of the American Chemical Society (27-04-2016)“…Aquaporins (AQPs) are biological water channels known for fast water transport (∼108–109 molecules/s/channel) with ion exclusion. Few synthetic channels have…”
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Artificial water channels—deconvolution of natural Aquaporins through synthetic design
Published in npj clean water (01-08-2018)“…Artificial Water Channels (AWCs) have been developed during the last decade with the hope to construct artificial analogues of Aquaporin (AQP) proteins. Their…”
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Columnar Self-Assemblies of Triarylamines as Scaffolds for Artificial Biomimetic Channels for Ion and for Water Transport
Published in Journal of the American Chemical Society (15-03-2017)“…Triarylamine molecules appended with crown-ethers or carboxylic moieties form self-assembled supramolecular channels within lipid bilayers. Fluorescence assays…”
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Biomimetic Artificial Proton Channels
Published in Biomolecules (Basel, Switzerland) (13-10-2022)“…One of the most common biochemical processes is the proton transfer through the cell membranes, having significant physiological functions in living organisms…”
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Artificial Gramicidins
Published in Frontiers in chemistry (04-09-2019)“…Gramicidin A, gA is a natural protein channel with a well-established, simple structure, and function: cations and water are transported together along the…”
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A class of carbonic anhydrase I - selective activators
Published in Journal of enzyme inhibition and medicinal chemistry (01-01-2017)“…A series of ureido and bis-ureido derivatives were prepared by reacting histamine with alkyl/aryl-isocyanates or di-isocyanates. The obtained derivatives were…”
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Squalyl Crown Ether Self-Assembled Conjugates: An Example of Highly Selective Artificial K+ Channels
Published in Chemistry : a European journal (05-02-2016)“…The natural KcsA K+ channel, one of the best‐characterized biological pore structures, conducts K+ cations at high rates while excluding Na+ cations. The KcsA…”
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Bis-15-crown-5-ether-pillar[5]arene K+‑Responsive Channels
Published in Organic letters (17-03-2017)“…An artificial selective K+ channel is formed from the supramolecular organization on bis(benzo-15-crown-5- ether-ureido)-pillar[5]arene compound. This…”
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Biomimetic Approach for Ion Channels Based on Surfactant Encapsulated Spherical Porous Metal-Oxide Capsules
Published in Advanced materials (Weinheim) (01-09-2015)“…Distinguished hybrid clusters with hydrophilic and hydrophobic interiors embedded within cationic surfactant shells are spontaneously inserted into lipid…”
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