Search Results - "Barbirz, Stefanie"

Biological foundations of successful bacteriophage therapy by Venturini, Carola, Petrovic Fabijan, Aleksandra, Fajardo Lubian, Alicia, Barbirz, Stefanie, Iredell, Jonathan

“…Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous in nature, phages can be used to treat bacterial infections (phage…”
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Bacteriophage tailspike protein based assay to monitor phase variable glucosylations in Salmonella O-antigens by Schmidt, Andreas, Rabsch, Wolfgang, Broeker, Nina K, Barbirz, Stefanie

“…Non-typhoid Salmonella Typhimurium (S. Typhimurium) accounts for a high number of registered salmonellosis cases, and O-serotyping is one important tool for…”
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In vitro Analysis of O-Antigen-Specific Bacteriophage P22 Inactivation by Salmonella Outer Membrane Vesicles by Stephan, Mareike S., Broeker, Nina K., Saragliadis, Athanasios, Roos, Norbert, Linke, Dirk, Barbirz, Stefanie

“…Bacteriophages use a large number of different bacterial cell envelope structures as receptors for surface attachment. As a consequence, bacterial surfaces…”
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Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens by Kunstmann, Sonja, Scheidt, Tom, Buchwald, Saskia, Helm, Alexandra, Mulard, Laurence A, Fruth, Angelika, Barbirz, Stefanie

“…Bacteriophage research is gaining more importance due to increasing antibiotic resistance. However, for treatment with bacteriophages, diagnostics have to be…”
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Area Increase and Budding in Giant Vesicles Triggered by Light: Behind the Scene by Georgiev, Vasil N., Grafmüller, Andrea, Bléger, David, Hecht, Stefan, Kunstmann, Sonja, Barbirz, Stefanie, Lipowsky, Reinhard, Dimova, Rumiana

“…Biomembranes are constantly remodeled and in cells, these processes are controlled and modulated by an assortment of membrane proteins. Here, it is shown that…”
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Crystal structure of Escherichia coli phage HK620 tailspike: podoviral tailspike endoglycosidase modules are evolutionarily related by Barbirz, Stefanie, Müller, Jürgen J, Uetrecht, Charlotte, Clark, Alvin J, Heinemann, Udo, Seckler, Robert

“…Bacteriophage HK620 infects Escherichia coli H and is closely related to Shigella phage Sf6 and Salmonella phage P22. All three Podoviridae recognize and…”
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A trimeric coiled-coil motif binds bacterial lipopolysaccharides with picomolar affinity by Hatlem, Daniel, Christensen, Mikkel, Broeker, Nina K, Kristiansen, Per E, Lund, Reidar, Barbirz, Stefanie, Linke, Dirk

“…α-helical coiled-coils are ubiquitous protein structures in all living organisms. For decades, modified coiled-coils sequences have been used in biotechnology,…”
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In Vitro Studies of Lipopolysaccharide-Mediated DNA Release of Podovirus HK620 by Broeker, Nina K, Kiele, Franziska, Casjens, Sherwood R, Gilcrease, Eddie B, Thalhammer, Anja, Koetz, Joachim, Barbirz, Stefanie

“…Gram-negative bacteria protect themselves with an outermost layer containing lipopolysaccharide (LPS). O-antigen-specific bacteriophages use tailspike proteins…”
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Mass Spectrometry Unravels Disulfide Bond Formation as the Mechanism That Activates a Molecular Chaperone by Barbirz, Stefanie, Jakob, Ursula, Glocker, Michael O.

“…The heat shock protein Hsp33 is a very potent molecular chaperone with a distinctive mode of functional regulation; its activity is redox-regulated. In its…”
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Purely Polysaccharide-Based Biofilm Matrix Provides Size-Selective Diffusion Barriers for Nanoparticles and Bacteriophages by Dunsing, Valentin, Irmscher, Tobias, Barbirz, Stefanie, Chiantia, Salvatore

“…Biofilms are complex mixtures of proteins, DNA, and polysaccharides surrounding bacterial communities as protective barriers that can be biochemically modified…”
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Not a barrier but a key: How bacteriophages exploit host's O‐antigen as an essential receptor to initiate infection by Broeker, Nina K., Barbirz, Stefanie

“…Summary Tailed bacteriophages specific for Gram‐negative bacteria encounter lipopolysaccharide (LPS) during the first infection steps. Yet, it is not well…”
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Buchrezension zu: Bakteriophagen: Bakteriophagen Wenn Antibiotika nicht mehr helfen–mit Viren gegen multiresistente, Keime Thomas Häusler, Christian Kühn, 224 S, Südwest, 2022. SC, 20,- €. ISBN: 9783517100432 by Barbirz, Stefanie

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Bacterial Mimetic Systems for Studying Bacterial Inactivation and Infection by Stephan, Mareike, Barbirz, Stefanie, Robinson, Tom, Yandrapalli, Naresh, Dimova, Rumiana

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Biomimetic asymmetric bacterial membranes incorporating lipopolysaccharides by Stephan, Mareike S., Dunsing, Valentin, Pramanik, Shreya, Chiantia, Salvatore, Barbirz, Stefanie, Robinson, Tom, Dimova, Rumiana

“…Gram-negative bacteria are equipped with a cell wall that contains a complex matrix of lipids, proteins, and glycans, which form a rigid layer protecting…”
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Pantoea stewartii WceF is a glycan biofilm-modifying enzyme with a bacteriophage tailspike-like fold by Irmscher, Tobias, Roske, Yvette, Gayk, Igor, Dunsing, Valentin, Chiantia, Salvatore, Heinemann, Udo, Barbirz, Stefanie

“…Pathogenic microorganisms often reside in glycan-based biofilms. Concentration and chain length distribution of these mostly anionic exopolysaccharides (EPS)…”
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Increasing the Affinity of an O‐Antigen Polysaccharide Binding Site in Shigella flexneri Bacteriophage Sf6 Tailspike Protein by Kunstmann, Sonja, Engström, Olof, Wehle, Marko, Widmalm, Göran, Santer, Mark, Barbirz, Stefanie

“…Broad and unspecific use of antibiotics accelerates spread of resistances. Sensitive and robust pathogen detection is thus important for a more targeted…”
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Time-resolved DNA release from an O-antigen–specific Salmonella bacteriophage with a contractile tail by Broeker, Nina K., Roske, Yvette, Valleriani, Angelo, Stephan, Mareike S., Andres, Dorothee, Koetz, Joachim, Heinemann, Udo, Barbirz, Stefanie

“…Myoviruses, bacteriophages with T4-like architecture, must contract their tails prior to DNA release. However, quantitative kinetic data on myovirus particle…”
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Tailspike Interactions with Lipopolysaccharide Effect DNA Ejection from Phage P22 Particles in Vitro by Andres, Dorothee, Hanke, Christin, Baxa, Ulrich, Seul, Anaït, Barbirz, Stefanie, Seckler, Robert

“…Initial attachment of bacteriophage P22 to the Salmonella host cell is known to be mediated by interactions between lipopolysaccharide (LPS) and the phage…”
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Solvent Networks Tune Thermodynamics of Oligosaccharide Complex Formation in an Extended Protein Binding Site by Kunstmann, Sonja, Gohlke, Ulrich, Broeker, Nina K, Roske, Yvette, Heinemann, Udo, Santer, Mark, Barbirz, Stefanie

“…The principles of protein–glycan binding are still not well understood on a molecular level. Attempts to link affinity and specificity of glycan recognition to…”
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Conformational Diversity of O‑Antigen Polysaccharides of the Gram-Negative Bacterium Shigella flexneri Serotype Y by Kang, Yu, Barbirz, Stefanie, Lipowsky, Reinhard, Santer, Mark

“…O-Antigen polysaccharides constitute the outer protective layer of most Gram-negative bacteria, important for the bacterium’s survival and adaption within its…”
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