Search Results - "Barberá, Víctor M."

Presenilin 1 Modulates Acetylcholinesterase Trafficking and Maturation by Cortés-Gómez, María-Ángeles, Barberá, Víctor M, Alom, Jordi, Sáez-Valero, Javier, García-Ayllón, María-Salud

“…In Alzheimer's disease (AD), the reduction in acetylcholinesterase (AChE) enzymatic activity is not paralleled with changes in its protein levels, suggesting…”
Get full text

CLytA-DAAO Chimeric Enzyme Bound to Magnetic Nanoparticles. A New Therapeutical Approach for Cancer Patients? by Fuentes-Baile, María, Pérez-Valenciano, Elizabeth, García-Morales, Pilar, de Juan Romero, Camino, Bello-Gil, Daniel, Barberá, Víctor M, Rodríguez-Lescure, Álvaro, Sanz, Jesús M, Alenda, Cristina, Saceda, Miguel

“…D-amino acid oxidase (DAAO) is an enzyme that catalyzes the oxidation of D-amino acids generating H O . The enzymatic chimera formed by DAAO bound to the…”
Get full text

Cell Death Mechanisms Induced by CLytA-DAAO Chimeric Enzyme in Human Tumor Cell Lines by Fuentes-Baile, María, García-Morales, Pilar, Pérez-Valenciano, Elizabeth, Ventero, María P, Sanz, Jesús M, de Juan Romero, Camino, Barberá, Víctor M, Alenda, Cristina, Saceda, Miguel

“…The combination of the choline binding domain of the amidase N-acetylmuramoyl-L-alanine (CLytA)-D-amino acid oxidase (DAAO) (CLytA-DAAO) and D-Alanine induces…”
Get full text

CLytA-DAAO, Free and Immobilized in Magnetic Nanoparticles, induces Cell Death in Human Cancer Cells by Fuentes-Baile, María, Bello-Gil, Daniel, Pérez-Valenciano, Elizabeth, Sanz, Jesús M, García-Morales, Pilar, Maestro, Beatriz, Ventero, María P, Alenda, Cristina, Barberá, Víctor M, Saceda, Miguel

“…D-amino acid oxidase (DAAO) catalyzes the oxidation of D-amino acids generating hydrogen peroxide, a potential producer of reactive oxygen species. In this…”
Get full text

Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines by Fuentes-Baile, María, Ventero, María P, Encinar, José A, García-Morales, Pilar, Poveda-Deltell, María, Pérez-Valenciano, Elizabeth, Barberá, Víctor M, Gallego-Plazas, Javier, Rodríguez-Lescure, Álvaro, Martín-Nieto, José, Saceda, Miguel

“…We have determined the effects of the IGF-1R tyrosine kinase inhibitors BMS-754807 (BMS) and OSI-906 (OSI) on cell proliferation and cell-cycle phase…”
Get full text

Methylation Analysis of MLH1 Improves the Selection of Patients for Genetic Testing in Lynch Syndrome by Pérez-Carbonell, Lucía, Alenda, Cristina, Payá, Artemio, Castillejo, Adela, Barberá, Víctor M, Guillén, Carmen, Rojas, Estefanía, Acame, Nuria, Gutiérrez-Aviñó, Francisco J, Castells, Antoni, Llor, Xavier, Andreu, Montserrat, Soto, José-Luis, Jover, Rodrigo

“…Inactivation of MLH1 due to promoter hypermethylation strongly suggests a sporadic origin, providing exclusion criteria for Lynch syndrome. The aim of this…”
Get full text

Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines by García-Morales, Pilar, Gómez-Martínez, Angeles, Carrato, Alfredo, Martínez-Lacaci, Isabel, Barberá, Víctor M., Soto, José L., Carrasco-García, Estefanía, Menéndez-Gutierrez, María P., Castro-Galache, María D., Ferragut, José A., Saceda, Miguel

“…The antitumor activity of the histone deacetylase inhibitors was tested in three well-characterized pancreatic adenocarcinoma cell lines, IMIM-PC-1, IMIM-PC-2,…”
Get full text

Identification of new targets for glioblastoma therapy based on a DNA expression microarray by Larriba, Eduardo, de Juan Romero, Camino, García-Martínez, Araceli, Quintanar, Teresa, Rodríguez-Lescure, Álvaro, Soto, José Luis, Saceda, Miguel, Martín-Nieto, José, Barberá, Víctor M.

“…This study provides a comprehensive perspective on the deregulated pathways and impaired biological functions prevalent in human glioblastoma (GBM). In order…”
Get full text

Biallelic MYH germline mutations as cause of Muir-Torre syndrome by Guillén-Ponce, Carmen, Castillejo, Adela, Barberá, Víctor M., Pascual-Ramírez, J. Carlos, Andrada, Encarnación, Castillejo, M. Isabel, Guarinós, Carla, Molina-Garrido, M. J., Carrato, Alfredo, Soto, J. L.

“…Muir-Torre syndrome is a rare, inherited disease predisposing of gastrointestinal and cutaneous tumours, such as keratoacanthomas and sebaceous gland adenomas…”
Get full text

Implementation of massive sequencing in the genetic diagnosis of hereditary cancer syndromes: diagnostic performance in the Hereditary Cancer Programme of the Valencia Community (FamCan-NGS) by Ramírez-Calvo, Marta, García-Casado, Zaida, Fernández-Serra, Antonio, de Juan, Inmaculada, Palanca, Sarai, Oltra, Silvestre, Soto, José Luis, Castillejo, Adela, Barbera, Víctor M, Juan-Fita, Ma José, Segura, Ángel, Chirivella, Isabel, Sánchez, Ana Beatriz, Tena, Isabel, Chaparro, Carolina, Salas, Dolores, López-Guerrero, José Antonio

“…Approximately 5 to 10% of all cancers are caused by inherited germline mutations, many of which are associated with different Hereditary Cancer Syndromes…”
Get full text

Utility of p16 Immunohistochemistry for the Identification of Lynch Syndrome by PAYA, Artemio, ALENDA, Cristina, LLOR, Xavier, ANDREU, Montserrat, KOH, Jim, ENDERS, Greg H, BENLLOCH, Susana, JOVER, Rodrigo, PEREZ-CARBONELL, Lucía, ROJAS, Estefanía, SOTO, José-Luis, GUILLEN, Carmen, CASTILLEJO, Adela, BARBERA, Victor M, CARRATO, Alfredo, CASTELLS, Antoni

“…Purpose: Immunohistochemistry for mismatch repair proteins has shown utility in the identification of Lynch syndrome, but majority of tumors with loss of MLH1…”
Get full text

Pancreatic Cancer Risk in Relation to Lifetime Smoking Patterns, Tobacco Type, and Dose-Response Relationships by Molina-Montes, Esther, Van Hoogstraten, Lisa, Gomez-Rubio, Paulina, Löhr, Matthias, Sharp, Linda, Molero, Xavier, Márquez, Mirari, Michalski, Christoph W, Farré, Antoni, Perea, José, O'Rorke, Michael, Greenhalf, William, Ilzarbe, Lucas, Tardon, Adonina, Gress, Thomas M, Barberà, Victor M, Crnogorac-Jurcevic, Tatjana, Muñoz-Bellvis, Luis, Domínguez-Muñoz, Enrique, Balsells, Joaquim, Costello, Eithne, Iglesias, Mar, Kleeff, Jorg, Kong, Bo, Mora, Josefina, O'Driscoll, Damian, Poves, Ignasi, Scarpa, Aldo, Yu, Jingru, Ye, Weimin, Hidalgo, Manuel, Carrato, Alfredo, Lawlor, Rita, Real, Francisco X, Malats, Nuria

“…Despite smoking being a well-established risk factor for pancreatic cancer, there is a need to further characterize pancreatic cancer risk according to…”
Get full text

Comparison between universal molecular screening for Lynch syndrome and revised Bethesda guidelines in a large population-based cohort of patients with colorectal cancer by Pérez-Carbonell, Lucía, Ruiz-Ponte, Clara, Guarinos, Carla, Alenda, Cristina, Payá, Artemio, Brea, Alejandro, Egoavil, Cecilia M, Castillejo, Adela, Barberá, Victor M, Bessa, Xavier, Xicola, Rosa M, Rodríguez-Soler, María, Sánchez-Fortún, Cristina, Acame, Nuria, Castellví-Bel, Sergi, Piñol, Virgínia, Balaguer, Francesc, Bujanda, Luis, De-Castro, María-Luisa, Llor, Xavier, Andreu, Montserrat, Carracedo, Angel, Soto, José-Luis, Castells, Antoni, Jover, Rodrigo

“…The selection of patients for genetic testing to rule out Lynch syndrome is currently based on fulfilment of at least one of the revised Bethesda criteria…”
Get more information

Risk of Cancer in Cases of Suspected Lynch Syndrome Without Germline Mutation by Rodríguez–Soler, María, Pérez–Carbonell, Lucía, Guarinos, Carla, Zapater, Pedro, Castillejo, Adela, Barberá, Victor M, Juárez, Miriam, Bessa, Xavier, Xicola, Rosa M, Clofent, Juan, Bujanda, Luis, Balaguer, Francesc, Reñé, Josep–Maria, de–Castro, Luisa, Marín–Gabriel, José C, Lanas, Angel, Cubiella, Joaquín, Nicolás–Pérez, David, Brea–Fernández, Alejandro, Castellví–Bel, Sergi, Alenda, Cristina, Ruiz–Ponte, Clara, Carracedo, Angel, Castells, Antoni, Andreu, Montserrat, Llor, Xavier, Soto, José L, Payá, Artemio, Jover, Rodrigo

“…Background & Aims Colorectal cancers (CRCs) with microsatellite instability (MSI) and a mismatch repair (MMR) immunohistochemical deficit without…”
Get full text

Pancreatic cancer and autoimmune diseases: An association sustained by computational and epidemiological case–control approaches by Gomez‐Rubio, Paulina, Piñero, Janet, Molina‐Montes, Esther, Gutiérrez‐Sacristán, Alba, Marquez, Mirari, Rava, Marta, Michalski, Christoph W., Farré, Antoni, Molero, Xavier, Löhr, Matthias, Perea, José, Greenhalf, William, O'Rorke, Michael, Tardón, Adonina, Gress, Thomas, Barberá, Victor M., Crnogorac‐Jurcevic, Tatjana, Muñoz‐Bellvís, Luís, Domínguez‐Muñoz, Enrique, Balsells, Joaquim, Costello, Eithne, Yu, Jingru, Iglesias, Mar, Ilzarbe, Lucas, Kleeff, Jörg, Kong, Bo, Mora, Josefina, Murray, Liam, O'Driscoll, Damian, Poves, Ignasi, Lawlor, Rita T., Ye, Weimin, Hidalgo, Manuel, Scarpa, Aldo, Sharp, Linda, Carrato, Alfredo, Real, Francisco X., Furlong, Laura I., Malats, Núria

“…Deciphering the underlying genetic basis behind pancreatic cancer (PC) and its associated multimorbidities will enhance our knowledge toward PC control. The…”
Get full text

Lack of cytomegalovirus detection in human glioma by Garcia-Martinez, Araceli, Alenda, Cristina, Irles, Esperanza, Ochoa, Enrique, Quintanar, Teresa, Rodriguez-Lescure, Alvaro, Soto, Jose L, Barbera, Victor M

“…Gliomas are the most common brain tumors and include a variety of histologic types and grades of malignancy. They arise from glial cells and represent…”
Get full text

Prevalence of MLH1 constitutional epimutations as a cause of Lynch syndrome in unselected versus selected consecutive series of patients with colorectal cancer by Castillejo, Adela, Hernández-Illán, Eva, Rodriguez-Soler, María, Pérez-Carbonell, Lucía, Egoavil, Cecilia, Barberá, Victor M, Castillejo, María-Isabel, Guarinos, Carla, Martínez-de-Dueñas, Eduardo, Juan, María-Jose, Sánchez-Heras, Ana-Beatriz, García-Casado, Zaida, Ruiz-Ponte, Clara, Brea-Fernández, Alejandro, Juárez, Miriam, Bujanda, Luis, Clofent, Juan, Llor, Xavier, Andreu, Montserrat, Castells, Antoni, Carracedo, Angel, Alenda, Cristina, Payá, Artemio, Jover, Rodrigo, Soto, José-Luis

“…The prevalence of MLH1 constitutional epimutations in the general population is unknown. We sought to analyse the prevalence of MLH1 constitutional…”
Get more information

The 18q21 region in colorectal and pancreatic cancer: independent loss of DCC and DPC4 expression by Barberá, Victor M, Martı́n, Mercè, Mariñoso, Luisa, Munné, Assumpta, Carrato, Alfredo, Real, Francisco X, Fabre, Myriam

“…The 18q21 region is frequently altered in gastrointestinal tumors. Three candidate tumor suppressor genes have been identified in it: DCC, Smad4/DPC4 and…”
Get full text

Sa1945 Molecular Characterization of Serrated Polyps Can Differentiate More Advanced Lesions by Juarez-Quesada, Miriam, Egoavil, Cecilia M, Rodriguez-Soler, Maria, Guarinos, Carla, Hernandez-Illan, Eva, Pérez-Carbonell, Lucía, Andreu-Martinez, Laura, Castaño-Soler, Lucia, Martínez, Juan, Ruiz, Francisco, Compañy, Luis, Aparicio, Jose Ramon, Casellas, Juan Antonio, Barberá, Victor M, Castillejo, Adela, Soto, José-Luis, Jover, Rodrigo

Get full text

Familiy history of cancer and diabetes and pancreatic cancer risk by Molina-Montes, Esther, Gómez-Rubio, Paulina, Barberà, Víctor M, Carrato, Alfredo, Crnogorac-Jurcevic, Tatjana, Domínguez-Muñoz, Enrique, Farré, Antonio, Greenhalf, William, Gress, Thomas, Hidalgo, Manuel, Ilzarbe, Lucas, Michalski, Christoph W, Löhr, Matthias, Marquez, Mirari, Molero, Xavier, Muñoz-Bellvís, Luís, Murray, Liam, Perea, José, Scarpa, Aldo, Sharp, Linda, Tardón, Adonina, Real, Francisco X, Malats, Núria

Get full text