Search Results - "Barber, David M"

Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers by Trads, Julie B., Hüll, Katharina, Matsuura, Bryan S., Laprell, Laura, Fehrentz, Timm, Görldt, Nicole, Kozek, Krystian A., Weaver, C. David, Klöcker, Nikolaj, Barber, David M., Trauner, Dirk

“…Photopharmacology relies on ligands that change their pharmacodynamics upon photoisomerization. Many of these ligands are azobenzenes that are…”
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One-Pot Catalytic Enantioselective Synthesis of Tetrahydropyridines via a Nitro-Mannich/Hydroamination Cascade by Barber, David M, Sanganee, Hitesh J, Dixon, Darren J

“…The highly enantioselective preparation of synthetically useful tetrahydropyridine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is…”
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Optical control of AMPA receptors using a photoswitchable quinoxaline-2,3-dione antagonist by Barber, David M, Liu, Shu-An, Gottschling, Kevin, Sumser, Martin, Hollmann, Michael, Trauner, Dirk

“…AMPA receptors respond to the neurotransmitter glutamate and play a critical role in excitatory neurotransmission. They have been implicated in several…”
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A New Family of Cinchona-Derived Bifunctional Asymmetric Phase-Transfer Catalysts: Application to the Enantio- and Diastereoselective Nitro-Mannich Reaction of Amidosulfones by Johnson, Kayli M, Rattley, Matt S, Sladojevich, Filippo, Barber, David M, Nuñez, Marta G, Goldys, Anna M, Dixon, Darren J

“…A new family of bifunctional H-bond donor phase-transfer catalysts derived from cinchona alkaloids has been developed and evaluated in the enantio- and…”
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A Competitive Edge: Competitor Inspired Scaffold Hopping in Herbicide Lead Optimization by Barber, David M.

“…Over the years, scaffold hopping has proven to be a powerful tool in the agrochemical optimization process. It offers the opportunity to modify known molecular…”
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Dual Amine and Palladium Catalysis in Diastereo- and Enantioselective Allene Carbocyclization Reactions by Li, Meiling, Datta, Swarup, Barber, David M, Dixon, Darren J

“…A pyrrolidine and Pd catalyzed diastereoselective carbocyclization of aldehyde and ketone-linked allenes has been developed. The cooperative…”
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Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO) by Barber, David M, Schönberger, Matthias, Burgstaller, Jessica, Levitz, Joshua, Weaver, C David, Isacoff, Ehud Y, Baier, Herwig, Trauner, Dirk

“…G-protein coupled inwardly rectifying potassium channels (GIRKs) are ubiquitously expressed throughout the human body and are an integral part of inhibitory…”
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One-pot nitro-Mannich/hydroamination cascades for the direct synthesis of 2,5-disubstituted pyrroles using base and gold catalysis by Barber, David M, Sanganee, Hitesh, Dixon, Darren J

“…An efficient, easy to perform, one-pot reaction cascade for the synthesis of 2,5-disubstituted pyrroles from p-toluenesulfonyl protected imines and…”
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Enantioselective Michael Addition/Iminium Ion Cyclization Cascades of Tryptamine-Derived Ureas by Aillaud, Isabelle, Barber, David M, Thompson, Amber L, Dixon, Darren J

“…A Michael addition/iminium ion cyclization cascade of enones with tryptamine-derived ureas under BINOL phosphoric acid (BPA) catalysis is reported. The cascade…”
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Synthesis and biological profile of 2,3-dihydro[1,3]thiazolo[4,5- b ]pyridines, a novel class of acyl-ACP thioesterase inhibitors by Frackenpohl, Jens, Barber, David M, Bojack, Guido, Bollenbach-Wahl, Birgit, Braun, Ralf, Getachew, Rahel, Hohmann, Sabine, Ko, Kwang-Yoon, Kurowski, Karoline, Laber, Bernd, Mattison, Rebecca L, Müller, Thomas, Reingruber, Anna M, Schmutzler, Dirk, Svejda, Andrea

“…The present work covers novel herbicidal lead structures that contain a 2,3-dihydro[1,3]thiazolo[4,5- ]pyridine scaffold as structural key feature carrying a…”
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Catalytic Asymmetric Alkylation Reactions for the Construction of Protected Ethylene-Amino and Propylene-Amino Motifs Attached to Quaternary Stereocentres by Moss, Thomas A., Barber, David M., Kyle, Andrew F., Dixon, Darren J.

“…An efficient catalytic and stereoselective method for the direct construction of protected ethylene‐amino and propylene‐amino scaffolds attached to quaternary…”
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One-Pot Asymmetric Nitro-Mannich/Hydroamination Cascades for the Synthesis of Pyrrolidine Derivatives: Combining Organocatalysis and Gold Catalysis by Barber, David M, Ďuriš, Andrej, Thompson, Amber L, Sanganee, Hitesh J, Dixon, Darren J

“…The highly enantioselective preparation of trisubstituted pyrrolidine derivatives employing a one-pot nitro-Mannich/hydroamination cascade is reported. This…”
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Total Synthesis of (+)‐Cornexistin by Steinborn, Christian, Wildermuth, Raphael E., Barber, David M., Magauer, Thomas

“…Herein, we describe the first total synthesis of (+)‐cornexistin as well as its 8‐epi‐isomer starting from malic acid. The robust and scalable route features a…”
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Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α‐Fluorinated Ketones by Thomson, Connor J., Barber, David M., Dixon, Darren J.

“…The catalytic enantioselective synthesis of α‐fluorinated chiral tertiary alcohols from (hetero)aryl methyl ketones is described. The use of a bifunctional…”
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Strategies for the Enantioselective Synthesis of 2‐Isoxazolines and 2‐Isoxazolin‐5‐ones Bearing Fully Substituted Stereocenters by McArthur, Gillian, Abel, Steven, Volpin, Giulio, Barber, David M.

“…Although there is an abundance of methods for the enantioselective synthesis of 2‐isoxazolines and 2‐isoxazolin‐5‐ones, relatively few of these approaches have…”
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Innovations in crop protection towards sustainable agriculture by Barber, David M., Jackson, Victoria E., Ling, Kenneth B.

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Total Synthesis of (+)‐Cornexistin by Steinborn, Christian, Wildermuth, Raphael E., Barber, David M., Magauer, Thomas

“…Herein, we describe the first total synthesis of (+)‐cornexistin as well as its 8‐epi‐isomer starting from malic acid. The robust and scalable route features a…”
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One‐Pot Catalytic Enantioselective Synthesis of 2‐Pyrazolines by Thomson, Connor J., Barber, David M., Dixon, Darren J.

“…A scalable, one‐pot, enantioselective catalytic synthesis of 2‐pyrazolines from beta‐substituted enones and hydrazines is described. Pivoting on a two‐stage…”
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Inspired by Nature: Isostere Concepts in Plant Hormone Chemistry by Frackenpohl, Jens, Abel, Steven A G, Alnafta, Neanne, Barber, David M, Bojack, Guido, Brant, Nicola Z, Helmke, Hendrik, Mattison, Rebecca L

“…Chemical concepts such as isosteres and scaffold hopping have proven to be powerful tools in agrochemical innovation processes. They offer opportunities to…”
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Investigations into Simplified Analogues of the Herbicidal Natural Product (+)‐Cornexistin by Steinborn, Christian, Tancredi, Aldo, Habiger, Christoph, Diederich, Christina, Kramer, Jan, Reingruber, Anna M., Laber, Bernd, Freigang, Jörg, Lange, Gudrun, Schmutzler, Dirk, Machettira, Anu, Besong, Gilbert, Magauer, Thomas, Barber, David M.

“…We report the design, synthesis and biological evaluation of simplified analogues of the herbicidal natural product (+)‐cornexistin. Guided by an X‐Ray…”
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