Search Results - "Barbee, Scott A"

FXS causing missense mutations disrupt FMRP granule formation, dynamics, and function by Starke, Emily L, Zius, Keelan, Barbee, Scott A

“…Fragile X Syndrome (FXS) is the most prevalent cause of inherited mental deficiency and is the most common monogenetic cause of autism spectral disorder (ASD)…”
Get full text

GW-Bodies and P-Bodies Constitute Two Separate Pools of Sequestered Non-Translating RNAs by Patel, Prajal H, Barbee, Scott A, Blankenship, J Todd

“…Non-translating RNAs that have undergone active translational repression are culled from the cytoplasm into P-bodies for decapping-dependent decay or for…”
Get full text

Vps54 Regulates Lifespan and Locomotor Behavior in Adult Drosophila melanogaster by Wilkinson, Emily C., Starke, Emily L., Barbee, Scott A.

“…Vps54 is an integral subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans…”
Get full text

Drosophila p38 MAPK interacts with BAG‐3/starvin to regulate age‐dependent protein homeostasis by Ryan, Sarah M., Almassey, Michael, Burch, Amelia M., Ngo, Gia, Martin, Julia M., Myers, David, Compton, Devin, Archie, Shira, Cross, Megan, Naeger, Lauren, Salzman, Ashley, Virola‐Iarussi, Alyssa, Barbee, Scott A., Mortimer, Nathan T., Sanyal, Subhabrata, Vrailas‐Mortimer, Alysia D.

“…As organisms age, they often accumulate protein aggregates that are thought to be toxic, potentially leading to age‐related diseases. This accumulation of…”
Get full text

FMRP cooperates with miRISC components to repress translation and regulate neurite morphogenesis in Drosophila by Kaul, Navneeta, Pradhan, Sarala J, Boin, Nathan G, Mason, Madeleine M, Rosales, Julian, Starke, Emily L, Wilkinson, Emily C, Chapman, Erich G, Barbee, Scott A

“…Fragile X Syndrome (FXS) is the most common inherited form of intellectual disability and is caused by mutations in the gene encoding the Fragile X messenger…”
Get full text

The miRNA pathway controls rapid changes in activity-dependent synaptic structure at the Drosophila melanogaster neuromuscular junction by Nesler, Katherine R, Sand, Robert I, Symmes, Breanna A, Pradhan, Sarala J, Boin, Nathan G, Laun, Anna E, Barbee, Scott A

“…It is widely accepted that long-term changes in synapse structure and function are mediated by rapid activity-dependent gene transcription and new protein…”
Get full text

GLD2 poly(A) polymerase is required for long-term memory by Kwak, Jae Eun, Drier, Eric, Barbee, Scott A, Ramaswami, Mani, Yin, Jerry C.P, Wickens, Marvin

“…The formation of long-term memory is believed to require translational control of localized mRNAs. In mammals, dendritic mRNAs are maintained in a repressed…”
Get full text

The conserved P body component HPat/Pat1 negatively regulates synaptic terminal growth at the larval Drosophila neuromuscular junction by Pradhan, Sarala J, Nesler, Katherine R, Rosen, Sarah F, Kato, Yasuko, Nakamura, Akira, Ramaswami, Mani, Barbee, Scott A

“…The temporal and spatial regulation of protein synthesis plays an important role in the control of neural physiology. In axons and dendrites, translationally…”
Get full text

Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density by Patel, Prajal H, Wilkinson, Emily C, Starke, Emily L, McGimsey, Malea R, Blankenship, J Todd, Barbee, Scott A

“…Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the -Golgi network…”
Get full text

Modification of lactoferrin by peroxynitrite reduces its antibacterial activity and changes protein structure by Alhalwani, Amani Y., Davey, Rachel L., Kaul, Navneeta, Barbee, Scott A., Huffman, J. Alex

Get full text

P-body components, microRNA regulation, and synaptic plasticity by Hillebrand, Jens, Barbee, Scott A, Ramaswami, Mani

“…What is the protein apparatus required for microRNA (miRNA) function and translational repression in neurons? This article reviews our recent work on Me31B, a…”
Get full text

Modification of lactoferrin by peroxynitrite reduces its antibacterial activity and changes protein structure by Alhalwani, Amani Y., Davey, Rachel L., Kaul, Navneeta, Barbee, Scott A., Alex Huffman, J.

“…Lactoferrin (LF) is a multifunctional protein that plays important physiological roles as one of the most concentrated proteins in many human and other…”
Get full text

Presynaptic CamKII regulates activity-dependent axon terminal growth by Nesler, Katherine R., Starke, Emily L., Boin, Nathan G., Ritz, Matthew, Barbee, Scott A.

“…Spaced synaptic depolarization induces rapid axon terminal growth and the formation of new synaptic boutons at the Drosophila larval neuromuscular junction…”
Get full text

Staufen- and FMRP-Containing Neuronal RNPs Are Structurally and Functionally Related to Somatic P Bodies by Barbee, Scott A., Estes, Patricia S., Cziko, Anne-Marie, Hillebrand, Jens, Luedeman, Rene A., Coller, Jeff M., Johnson, Nick, Howlett, Iris C., Geng, Cuiyun, Ueda, Ryu, Brand, Andrea H., Newbury, Sarah F., Wilhelm, James E., Levine, Richard B., Nakamura, Akira, Parker, Roy, Ramaswami, Mani

“…Local control of mRNA translation modulates neuronal development, synaptic plasticity, and memory formation. A poorly understood aspect of this control is the…”
Get full text

Genetic modifiers of dFMR1 encode RNA granule components in Drosophila by Cziko, Anne-Marie J, McCann, Cathal T, Howlett, Iris C, Barbee, Scott A, Duncan, Rebecca P, Luedemann, Rene, Zarnescu, Daniela, Zinsmaier, Konrad E, Parker, Roy R, Ramaswami, Mani

“…Mechanisms of neuronal mRNA localization and translation are of considerable biological interest. Spatially regulated mRNA translation contributes to cell-fate…”
Get full text

The Sm proteins regulate germ cell specification during early C. elegans embryogenesis by Barbee, Scott A., Evans, Thomas C.

“…Sm and Sm-like proteins are core components of the splicesome but have other functions distinct from pre-mRNA processing. Here, we show that Sm proteins also…”
Get full text

A Novel Function for the Sm Proteins in Germ Granule Localization during C. elegans Embryogenesis by Barbee, Scott A., Lublin, Alex L., Evans, Thomas C.

“…General mRNA processing factors are traditionally thought to function only in the control of global gene expression. Here we show that the Sm proteins, core…”
Get full text

Vps54 regulates Drosophila neuromuscular junction development and interacts genetically with Rab7 to control composition of the postsynaptic density by Patel, Prajal H, Wilkinson, Emily C, Starke, Emily L, McGimsey, Malea R, Blankenship, J Todd, Barbee, Scott A

“…Vps54 is a subunit of the Golgi-associated retrograde protein (GARP) complex, which is involved in tethering endosome-derived vesicles to the trans-Golgi…”
Get full text

GW-Bodies and P-Bodies Constitute Two Separate Pools of Sequestered Non-Translating RNAs: e0150291 by Patel, Prajal H, Barbee, Scott A, Blankenship, J Todd

“…Non-translating RNAs that have undergone active translational repression are culled from the cytoplasm into P-bodies for decapping-dependent decay or for…”
Get full text

Exercise-Induced Stress Response as an Adaptive Tolerance Strategy by Sonneborn, Joan Smith, Barbee, Scott A.

Get full text