Search Results - "Barbaro, Andrea De Lerma"

Irradiated CIITA-positive mammary adenocarcinoma cells act as a potent anti-tumor-preventive vaccine by inducing tumor-specific CD4+ T cell priming and CD8+ T cell effector functions by Mortara, Lorenzo, Frangione, Valeria, Castellani, Patrizia, De Lerma Barbaro, Andrea, Accolla, Roberto S.

“…In the present study, we investigated the possibility to use irradiated, non-replicating class II transcriptional activator (CIITA)-transfected tumor TS/A…”
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Methylation of CIITA promoter IV causes loss of HLA-II inducibility by IFN-γ in promyelocytic cells by De Lerma Barbaro, Andrea, De Ambrosis, Alessandro, Banelli, Barbara, Pira, Giuseppina Li, Aresu, Ottavia, Romani, Massimo, Ferrini, Silvano, Accolla, Roberto S.

“…The human promyelocytic cell line THP-1 expresses high level of HLA class II (HLA-II) molecules after IFN-γ treatment. Here, we report a variant of THP-1 that…”
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CIITA-Induced MHC Class II Expression in Mammary Adenocarcinoma Leads to a Th1 Polarization of the Tumor Microenvironment, Tumor Rejection, and Specific Antitumor Memory by MORTARA, Lorenzo, CASTELLANI, Patrizia, MEAZZA, Raffaella, TOSI, Giovanna, DE LERMA BARBARO, Andrea, PROCOPIO, Francesco A, COMES, Alberto, ZARDI, Luciano, FERRINI, Silvano, ACCOLLA, Roberto S

“…Purpose: We have shown previously that the MHC class II–negative murine TS/A adenocarcinoma is rejected in vivo if induced to express MHC class II molecules by…”
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Therapy-induced antitumor vaccination by targeting tumor necrosis factor-α to tumor vessels in combination with melphalan by Mortara, Lorenzo, Balza, Enrica, Sassi, Francesca, Castellani, Patrizia, Carnemolla, Barbara, De Lerma Barbaro, Andrea, Fossati, Sara, Tosi, Giovanna, Accolla, Roberto S, Borsi, Laura

“…Treatment of tumor-bearing mice with mouse (m)TNF-α, targeted to tumor vasculature by the anti-ED-B fibronectin domain antibody L19(scFv) and combined with…”
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Inflammation, inflammatory cells and angiogenesis: decisions and indecisions by Noonan, Douglas M., De Lerma Barbaro, Andrea, Vannini, Nicola, Mortara, Lorenzo, Albini, Adriana

“…Endothelial-immune cell cross-talk goes well beyond leukocyte and lymphocyte trafficking, since immune cells are able to intimately regulate vessel formation…”
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Inhibition of Human T Cell Leukemia Virus Type 2 Replication by the Suppressive Action of Class II Transactivator and Nuclear Factor Y by Tosi, Giovanna, Pilotti, Elisabetta, Mortara, Lorenzo, De Lerma Barbaro, Andrea, Casoli, Claudio, Accolla, Roberto S.

“…The master regulator of MHC-II gene transcription, class II transactivator (CIITA), acts as a potent inhibitor of human T cell leukemia virus type 2 (HTLV-2)…”
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Surface protein components from entomopathogenic nematodes and their symbiotic bacteria: effects on immune responses of the greater wax moth, Galleria mellonella (Lepidoptera: Pyralidae) by Brivio, Maurizio Francesco, Toscano, Andrea, De Pasquale, Simone Maria, De Lerma Barbaro, Andrea, Giovannardi, Stefano, Finzi, Giovanna, Mastore, Maristella

“…BACKGROUND Steinernema carpocapsae is a nematocomplex widely used as an alternative to chemicals for the biological control of insect pests; this nematode is…”
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Neutrophil and Natural Killer Cell Interactions in Cancers: Dangerous Liaisons Instructing Immunosuppression and Angiogenesis by Palano, Maria Teresa, Gallazzi, Matteo, Cucchiara, Martina, De Lerma Barbaro, Andrea, Gallo, Daniela, Bassani, Barbara, Bruno, Antonino, Mortara, Lorenzo

“…The tumor immune microenvironment (TIME) has largely been reported to cooperate on tumor onset and progression, as a consequence of the phenotype/functional…”
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CIITA‐driven MHC‐II positive tumor cells: Preventive vaccines and superior generators of antitumor CD4+ T lymphocytes for immunotherapy by Frangione, Valeria, Mortara, Lorenzo, Castellani, Patrizia, De Lerma Barbaro, Andrea, Accolla, Roberto S.

“…In our study, we have investigated whether tumors of distinct histological origin can be rejected if expressing CIITA‐driven MHC class II molecules. Moreover,…”
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Metabolic Rewiring in the Tumor Microenvironment to Support Immunotherapy: A Focus on Neutrophils, Polymorphonuclear Myeloid-Derived Suppressor Cells and Natural Killer Cells by De Lerma Barbaro, Andrea, Palano, Maria Teresa, Cucchiara, Martina, Gallazzi, Matteo, Mortara, Lorenzo, Bruno, Antonino

“…Leukocytes often undergo rapid changes in cell phenotype, for example, from a resting to an activated state, which places significant metabolic demands on the…”
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In Vivo Effects of A Pro-PO System Inhibitor on the Phagocytosis of Xenorhabdus Nematophila in Galleria Mellonella Larvae by De Lerma Barbaro, Andrea, Gariboldi, Marzia B, Mastore, Maristella, Brivio, Maurizio F, Giovannardi, Stefano

“…is a Gram-negative bacterium symbiont of the entomopathogen nematode whose immunosuppressive properties over host's immune response have been thoroughly…”
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The complex liaison between cachexia and tumor burden (Review) by DE LERMA BARBARO, ANDREA

“…Cachexia is a wasting syndrome that afflicts end-stage cancer patients. Whereas a consensus statement for a definition of cachexia recently has been…”
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Block of Stat‐1 activation in macrophages phagocytosing bacteria causes reduced transcription of CIITA and consequent impaired antigen presentation by Barbaro, Andrea De Lerma, Tosi, Giovanna, Frumento, Guido, Bruschi, Emanuele, D'Agostino, Antonella, Valle, Maria‐Teresa, Manca, Fabrizio, Accolla, Roberto S.

“…The IFN‐γ‐induced HLA class II expression in human macrophages was drastically reduced after phagocytosis of Escherichia coli. HLA class II down‐modulation…”
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New strategies of mammary cancer vaccination by Accolla, Roberto S, Frangione, Valeria, De Lerma Barbaro, Andrea, Mortara, Lorenzo

“…A new strategy of vaccination against mammary tumors, extendible to tumors of distinct histological origin, based on the administration of tumor cells…”
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Experimental therapeutic approaches to adenocarcinoma: The potential of tumor cells engineered to express MHC class II molecules combined with naked DNA interleukin-12 gene transfer by Mortara, Lorenzo, Giuliani, Luca, De Lerma Barbaro, Andrea, Accolla, Roberto S, Noonan, Douglas M

“…Summary We have previously shown that TS/A murine mammary adenocarcinoma cells, induced to express high surface expression of MHC class II molecules by stable…”
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The HLA class II transcriptional activator blocks the function of HIV‐1 Tat and inhibits viral replication by Accolla, Roberto S., Mazza, Stefania, Barbaro, Andrea De Lerma, Maria, Andrea De, Tosi, Giovanna

“…The expression of HLA class II genes is under the control of a transcriptional activator, CIITA, encoded by the AIR‐1 locus. Here we show that CIITA inhibits…”
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The MHC class II transactivator (CIITA) mRNA stability is critical for the HLA class II gene expression in myelomonocytic cells by De Lerma Barbaro, Andrea, Procopio, Francesco A., Mortara, Lorenzo, Tosi, Giovanna, Accolla, Roberto S.

“…The human promyelocytic U937 cells express detectable levels of MHC class II (MHC‐II) molecules. Treatment with 12‐o‐‐tetradecanoyl phorbol 13‐acetate (TPA),…”
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HLA Class II Expression in Uninducible Hepatocarcinoma Cells After Transfection of AIR-1 Gene Product CIITA: Acquisition of Antigen Processing and Presentation Capacity by Sartoris, Silvia, Valle, Maria Teresa, Barbaro, Andrea De Lerma, Tosi, Giovanna, Cestari, Tiziana, D'Agostino, Antonella, Megiovanni, Anna Maria, Manca, Fabrizio, Accolla2, Roberto S

“…The AIR-1-encoded CIITA transcriptional activator is crucial for both constitutive and IFN-gamma-induced MHC class II gene transcription. We show here that the…”
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Active suppression of the class II transactivator-encoding AIR-1 locus is responsible for the lack of major histocompatibility complex class II gene expression observed during differentiation from B cells to plasma cells by Sartoris, S, Tosi, G, De Lerma Barbaro, A, Cestari, T, Accolla, R S

“…In this study the genetic control of major histocompatibility complex (MHC) class II gene expression during the transition from B cell to plasma cell has been…”
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Inhibition of human TI cell leukemia virus type 2 replication by the suppressive action of class II transactivator and nuclear factor Y by Tosi, Giovanna, Pilotti, Elisabetta, Mortara, Lorenzo, De Lerma Barbaro, Andrea

“…The master regulator of MHC-11 gene transcription, class II trans-activator (CIITA), acts as a potent inhibitor of human T cell leukemia virus type 2 (HTLV-2)…”
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