Search Results - "Barbara J. Flynn"

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite by Kisalu, Neville K, Idris, Azza H, Weidle, Connor, Flores-Garcia, Yevel, Flynn, Barbara J, Sack, Brandon K, Murphy, Sean, Schön, Arne, Freire, Ernesto, Francica, Joseph R, Miller, Alex B, Gregory, Jason, March, Sandra, Liao, Hua-Xin, Haynes, Barton F, Wiehe, Kevin, Trama, Ashley M, Saunders, Kevin O, Gladden, Morgan A, Monroe, Anthony, Bonsignori, Mattia, Kanekiyo, Masaru, Wheatley, Adam K, McDermott, Adrian B, Farney, S Katie, Chuang, Gwo-Yu, Zhang, Baoshan, Kc, Natasha, Chakravarty, Sumana, Kwong, Peter D, Sinnis, Photini, Bhatia, Sangeeta N, Kappe, Stefan H I, Sim, B Kim Lee, Hoffman, Stephen L, Zavala, Fidel, Pancera, Marie, Seder, Robert A

“…The identification of antibodies targeting a conserved site of vulnerability in the Plasmodium falciparum circumsporozoite protein reveals opportunities for…”
Get full text

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response by McNamara, Hayley A., Idris, Azza H., Sutton, Henry J., Vistein, Rachel, Flynn, Barbara J., Cai, Yeping, Wiehe, Kevin, Lyke, Kirsten E., Chatterjee, Deepyan, KC, Natasha, Chakravarty, Sumana, Lee Sim, B. Kim, Hoffman, Stephen L., Bonsignori, Mattia, Seder, Robert A., Cockburn, Ian A.

“…Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the…”
Get full text

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates by Francica, Joseph R, Laga, Richard, Lynn, Geoffrey M, Mužíková, Gabriela, Androvič, Ladislav, Aussedat, Baptiste, Walkowicz, William E, Padhan, Kartika, Ramirez-Valdez, Ramiro Andrei, Parks, Robert, Schmidt, Stephen D, Flynn, Barbara J, Tsybovsky, Yaroslav, Stewart-Jones, Guillaume B E, Saunders, Kevin O, Baharom, Faezzah, Petrovas, Constantinos, Haynes, Barton F, Seder, Robert A

“…Peptide immunogens provide an approach to focus antibody responses to specific neutralizing sites on the HIV envelope protein (Env) trimer or on other…”
Get full text

Variant-proof high affinity ACE2 antagonist limits SARS-CoV-2 replication in upper and lower airways by Gagne, Matthew, Flynn, Barbara J., Honeycutt, Christopher Cole, Flebbe, Dillon R., Andrew, Shayne F., Provost, Samantha J., McCormick, Lauren, Van Ry, Alex, McCarthy, Elizabeth, Todd, John-Paul M., Bao, Saran, Teng, I-Ting, Marciano, Shir, Rudich, Yinon, Li, Chunlin, Jain, Shilpi, Wali, Bushra, Pessaint, Laurent, Dodson, Alan, Cook, Anthony, Lewis, Mark G., Andersen, Hanne, Zahradník, Jiří, Suthar, Mehul S., Nason, Martha C., Foulds, Kathryn E., Kwong, Peter D., Roederer, Mario, Schreiber, Gideon, Seder, Robert A., Douek, Daniel C.

“…SARS-CoV-2 has the capacity to evolve mutations that escape vaccine- and infection-acquired immunity and antiviral drugs. A variant-agnostic therapeutic agent…”
Get full text

Immunization with HIV Gag targeted to dendritic cells followed by recombinant New York vaccinia virus induces robust T-cell immunity in nonhuman primates by Flynn, Barbara J, Kastenmüller, Kathrin, Wille-Reece, Ulrike, Tomaras, Georgia D, Alam, Munir, Lindsay, Ross W, Salazar, Andres M, Perdiguero, Beatriz, Gomez, Carmen E, Wagner, Ralf, Esteban, Mariano, Park, Chae G, Trumpfheller, Christine, Keler, Tibor, Pantaleo, Giuseppe, Steinman, Ralph M, Seder, Robert

“…Protein vaccines, if rendered immunogenic, would facilitate vaccine development against HIV and other pathogens. We compared in nonhuman primates (NHPs) immune…”
Get full text

Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection by Aguirre-Botero, Manuela C., Wang, Lawrence T., Formaglio, Pauline, Aliprandini, Eduardo, Thiberge, Jean-Michel, Schön, Arne, Flores-Garcia, Yevel, Mathis-Torres, Shamika, Flynn, Barbara J., da Silva Pereira, Lais, Le Duff, Yann, Hurley, Mathew, Nacer, Adéla, Bowyer, Paul W., Zavala, Fidel, Idris, Azza H., Francica, Joseph R., Seder, Robert A., Amino, Rogerio

“…Human monoclonal antibodies (hmAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on the sporozoite surface are a promising tool for…”
Get full text

HIV Gag Protein Conjugated to a Toll-like Receptor 7/8 Agonist Improves the Magnitude and Quality of Th1 and CD8+T Cell Responses in Nonhuman Primates by Ulrike Wille-Reece, Barbara J. Flynn, Karin Loré, Koup, Richard A., Kedl, Ross M., Mattapallil, Joseph J., Weiss, Walter R., Roederer, Mario, Seder, Robert A.

“…Induction and maintenance of antibody and T cell responses will be critical for developing a successful vaccine against HIV. A rational approach for generating…”
Get full text

Innate transcriptional effects by adjuvants on the magnitude, quality, and durability of HIV envelope responses in NHPs by Francica, Joseph R., Zak, Daniel E., Linde, Caitlyn, Siena, Emilio, Johnson, Carrie, Juraska, Michal, Yates, Nicole L., Gunn, Bronwyn, De Gregorio, Ennio, Flynn, Barbara J., Valiante, Nicholas M., Malyala, Padma, Barnett, Susan W., Sarkar, Pampi, Singh, Manmohan, Jain, Siddhartha, Ackerman, Margaret, Alam, Munir, Ferrari, Guido, Salazar, Andres, Tomaras, Georgia D., O'Hagan, Derek T., Aderem, Alan, Alter, Galit, Seder, Robert A.

“…Adjuvants have a critical role for improving vaccine efficacy against many pathogens, including HIV. Here, using transcriptional RNA profiling and systems…”
Get full text

Investigation of the impact of clonal hematopoiesis on severity and pathophysiology of COVID-19 in rhesus macaques by Shin, Tae-Hoon, Zhou, Yifan, Lee, Byung-Chul, Hong, So Gun, Andrew, Shayne F, Flynn, Barbara J, Gagne, Matthew, Todd, John-Paul M, Moore, Ian N, Cook, Anthony, Lewis, Mark G, Foulds, Kathryn E, Seder, Robert A, Douek, Daniel C, Roederer, Mario, Dunbar, Cynthia E

“…Clinical manifestations of COVID-19 vary widely, ranging from asymptomatic to severe respiratory failure with profound inflammation. Although risk factors for…”
Get full text

Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria by Francica, Joseph R, Shi, Wei, Chuang, Gwo-Yu, Chen, Steven J, Da Silva Pereira, Lais, Farney, S Katie, Flynn, Barbara J, Ou, Li, Stephens, Tyler, Tsybovsky, Yaroslav, Wang, Lawrence T, Anderson, Alexander, Beck, Zoltan, Dillon, Marlon, Idris, Azza H, Hurlburt, Nicholas, Liu, Tracy, Zhang, Baoshan, Alving, Carl R, Matyas, Gary R, Pancera, Marie, Mascola, John R, Kwong, Peter D, Seder, Robert A

“…The most advanced malaria vaccine, RTS,S, includes the central repeat and C-terminal domains of the circumsporozoite protein (PfCSP). We have recently isolated…”
Get full text

A Monoclonal Antibody for Malaria Prevention by Gaudinski, Martin R, Berkowitz, Nina M, Idris, Azza H, Coates, Emily E, Holman, LaSonji A, Mendoza, Floreliz, Gordon, Ingelise J, Plummer, Sarah H, Trofymenko, Olga, Hu, Zonghui, Campos Chagas, Andrezza, O’Connell, Sarah, Basappa, Manjula, Douek, Naomi, Narpala, Sandeep R, Barry, Christopher R, Widge, Alicia T, Hicks, Renunda, Awan, Seemal F, Wu, Richard L, Hickman, Somia, Wycuff, Diane, Stein, Judy A, Case, Christopher, Evans, Brian P, Carlton, Kevin, Gall, Jason G, Vazquez, Sandra, Flach, Britta, Chen, Grace L, Francica, Joseph R, Flynn, Barbara J, Kisalu, Neville K, Capparelli, Edmund V, McDermott, Adrian, Mascola, John R, Ledgerwood, Julie E, Seder, Robert A

“…Malaria remains a cause of substantial global morbidity and mortality. In this report, an engineered monoclonal antibody showed protection against malaria…”
Get full text

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver by Wang, Lawrence T., Pereira, Lais S., Flores-Garcia, Yevel, O’Connor, James, Flynn, Barbara J., Schön, Arne, Hurlburt, Nicholas K., Dillon, Marlon, Yang, Annie S.P., Fabra-García, Amanda, Idris, Azza H., Mayer, Bryan T., Gerber, Monica W., Gottardo, Raphael, Mason, Rosemarie D., Cavett, Nicole, Ballard, Reid B., Kisalu, Neville K., Molina-Cruz, Alvaro, Nelson, Jorgen, Vistein, Rachel, Barillas-Mury, Carolina, Amino, Rogerio, Baker, David, King, Neil P., Sauerwein, Robert W., Pancera, Marie, Cockburn, Ian A., Zavala, Fidel, Francica, Joseph R., Seder, Robert A.

“…Discovering potent human monoclonal antibodies (mAbs) targeting the Plasmodium falciparum circumsporozoite protein (PfCSP) on sporozoites (SPZ) and elucidating…”
Get full text

Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection by Lyke, Kirsten E., Ishizuka, Andrew S., Berry, Andrea A., Chakravarty, Sumana, DeZure, Adam, Enama, Mary E., James, Eric R., Billingsley, Peter F., Gunasekera, Anusha, Manoj, Anita, Li, Minglin, Ruben, Adam J., Li, Tao, Eappen, Abraham G., Stafford, Richard E., KC, Natasha, Murshedkar, Tooba, Mendoza, Floreliz H., Gordon, Ingelise J., Zephir, Kathryn L., Holman, LaSonji A., Plummer, Sarah H., Hendel, Cynthia S., Novik, Laura, Costner, Pamela J. M., Saunders, Jamie G., Berkowitz, Nina M., Flynn, Barbara J., Nason, Martha C., Garver, Lindsay S., Laurens, Matthew B., Plowe, Christopher V., Richie, Thomas L., Graham, Barney S., Roederer, Mario, Sim, B. Kim Lee, Ledgerwood, Julie E., Hoffman, Stephen L., Seder, Robert A.

“…A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ Vaccine), confers sterile protection against controlled human malaria…”
Get full text

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria by Wu, Richard L., Idris, Azza H., Berkowitz, Nina M., Happe, Myra, Gaudinski, Martin R., Buettner, Christian, Strom, Larisa, Awan, Seemal F., Holman, LaSonji A., Mendoza, Floreliz, Gordon, Ingelise J., Hu, Zonghui, Campos Chagas, Andrezza, Wang, Lawrence T., Da Silva Pereira, Lais, Francica, Joseph R., Kisalu, Neville K., Flynn, Barbara J., Shi, Wei, Kong, Wing-Pui, O’Connell, Sarah, Plummer, Sarah H., Beck, Allison, McDermott, Adrian, Narpala, Sandeep R., Serebryannyy, Leonid, Castro, Mike, Silva, Rosa, Imam, Marjaan, Pittman, Iris, Hickman, Somia P., McDougal, Andrew J., Lukoskie, Ashly E., Murphy, Jittawadee R., Gall, Jason G., Carlton, Kevin, Morgan, Patricia, Seo, Ellie, Stein, Judy A., Vazquez, Sandra, Telscher, Shinyi, Capparelli, Edmund V., Coates, Emily E., Mascola, John R., Ledgerwood, Julie E., Dropulic, Lesia K., Seder, Robert A.

“…This phase 1 trial examined an engineered monoclonal antibody, L9LS, targeting the sporozoite. L9LS protected against malaria infection in a human challenge…”
Get full text

Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major by Darrah, Patricia A, Patel, Dipti T, De Luca, Paula M, Lindsay, Ross W B, Davey, Dylan F, Flynn, Barbara J, Hoff, Søren T, Andersen, Peter, Reed, Steven G, Morris, Sheldon L, Roederer, Mario, Seder, Robert A

“…CD4+ T cells have a crucial role in mediating protection against a variety of pathogens through production of specific cytokines. However, substantial…”
Get full text

Protection from SARS-CoV-2 Delta one year after mRNA-1273 vaccination in rhesus macaques coincides with anamnestic antibody response in the lung by Gagne, Matthew, Corbett, Kizzmekia S., Flynn, Barbara J., Foulds, Kathryn E., Wagner, Danielle A., Andrew, Shayne F., Todd, John-Paul M., Honeycutt, Christopher Cole, McCormick, Lauren, Nurmukhambetova, Saule T., Davis-Gardner, Meredith E., Pessaint, Laurent, Bock, Kevin W., Nagata, Bianca M., Minai, Mahnaz, Werner, Anne P., Moliva, Juan I., Tucker, Courtney, Lorang, Cynthia G., Zhao, Bingchun, McCarthy, Elizabeth, Cook, Anthony, Dodson, Alan, Teng, I-Ting, Mudvari, Prakriti, Roberts-Torres, Jesmine, Laboune, Farida, Wang, Lingshu, Goode, Adrienne, Kar, Swagata, Boyoglu-Barnum, Seyhan, Yang, Eun Sung, Shi, Wei, Ploquin, Aurélie, Doria-Rose, Nicole, Carfi, Andrea, Mascola, John R., Boritz, Eli A., Edwards, Darin K., Andersen, Hanne, Lewis, Mark G., Suthar, Mehul S., Graham, Barney S., Roederer, Mario, Moore, Ian N., Nason, Martha C., Sullivan, Nancy J., Douek, Daniel C., Seder, Robert A.

“…mRNA-1273 vaccine efficacy against SARS-CoV-2 Delta wanes over time; however, there are limited data on the impact of durability of immune responses on…”
Get full text

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria by Wang, Lawrence T., Hurlburt, Nicholas K., Schön, Arne, Flynn, Barbara J., Flores-Garcia, Yevel, Pereira, Lais S., Kiyuka, Patience K., Dillon, Marlon, Bonilla, Brian, Zavala, Fidel, Idris, Azza H., Francica, Joseph R., Pancera, Marie, Seder, Robert A.

“…L9 is a potent human monoclonal antibody (mAb) that preferentially binds two adjacent NVDP minor repeats and cross-reacts with NANP major repeats of the…”
Get full text

Functional human IgA targets a conserved site on malaria sporozoites by Tan, Joshua, Cho, Hyeseon, Pholcharee, Tossapol, Pereira, Lais S, Doumbo, Safiatou, Doumtabe, Didier, Flynn, Barbara J, Schön, Arne, Kanatani, Sachie, Aylor, Samantha O, Oyen, David, Vistein, Rachel, Wang, Lawrence, Dillon, Marlon, Skinner, Jeff, Peterson, Mary, Li, Shanping, Idris, Azza H, Molina-Cruz, Alvaro, Zhao, Ming, Olano, Lisa Renee, Lee, Patricia J, Roth, Alison, Sinnis, Photini, Barillas-Mury, Carolina, Kayentao, Kassoum, Ongoiba, Aissata, Francica, Joseph R, Traore, Boubacar, Wilson, Ian A, Seder, Robert A, Crompton, Peter D

“…Immunoglobulin (Ig)A antibodies play a critical role in protection against mucosal pathogens. However, the role of serum IgA in immunity to nonmucosal…”
Get more information

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies by Kratochvil, Sven, Shen, Chen-Hsiang, Lin, Ying-Cing, Xu, Kai, Nair, Usha, Da Silva Pereira, Lais, Tripathi, Prabhanshu, Arnold, Johan, Chuang, Gwo-Yu, Melzi, Eleonora, Schön, Arne, Zhang, Baoshan, Dillon, Marlon, Bonilla, Brian, Flynn, Barbara J., Kirsch, Kathrin H., Kisalu, Neville K., Kiyuka, Patience K., Liu, Tracy, Ou, Li, Pancera, Marie, Rawi, Reda, Reveiz, Mateo, Seignon, Kareen, Wang, Lawrence T., Waring, Michael T., Warner, John, Yang, Yongping, Francica, Joseph R., Idris, Azza H., Seder, Robert A., Kwong, Peter D., Batista, Facundo D.

“…Repeat antigens, such as the Plasmodium falciparum circumsporozoite protein (PfCSP), use both sequence degeneracy and structural diversity to evade the immune…”
Get full text

Mucosal adenovirus vaccine boosting elicits IgA and durably prevents XBB.1.16 infection in nonhuman primates by Gagne, Matthew, Flynn, Barbara J., Andrew, Shayne F., Marquez, Josue, Flebbe, Dillon R., Mychalowych, Anna, Lamb, Evan, Davis-Gardner, Meredith E., Burnett, Matthew R., Serebryannyy, Leonid A., Lin, Bob C., Ziff, Zohar E., Maule, Erin, Carroll, Robin, Naisan, Mursal, Jethmalani, Yogita, Pessaint, Laurent, Todd, John-Paul M., Doria-Rose, Nicole A., Case, James Brett, Dmitriev, Igor P., Kashentseva, Elena A., Ying, Baoling, Dodson, Alan, Kouneski, Katelyn, O’Dell, Sijy, Wali, Bushra, Ellis, Madison, Godbole, Sucheta, Laboune, Farida, Henry, Amy R., Teng, I-Ting, Wang, Danyi, Wang, Lingshu, Zhou, Qiong, Zouantchangadou, Serge, Van Ry, Alex, Lewis, Mark G., Andersen, Hanne, Kwong, Peter D., Curiel, David T., Roederer, Mario, Nason, Martha C., Foulds, Kathryn E., Suthar, Mehul S., Diamond, Michael S., Douek, Daniel C., Seder, Robert A.

“…A mucosal route of vaccination could prevent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication at the site of infection and limit…”
Get full text