Innate lymphoid cells are pivotal actors in allergic, inflammatory and autoimmune diseases

Innate lymphoid cells are pivotal actors in allergic, inflammatory and autoimmune diseases

Innate lymphoid cells (ILCs) are lymphoid cells that do not express V(D)J-rearranged receptors and play a role in the innate immune system. ILCs are categorized into three groups with respect to their function in the immune system. ILC1 induces production of IFN-γ via T-box expressed on T cells, ILC...

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Bibliographic Details
Published in:Expert review of clinical immunology Vol. 11; no. 8; p. 885
Main Authors: Sanati, Golshid, Aryan, Zahra, Barbadi, Mehri, Rezaei, Nima
Format: Journal Article
Language:English
Published: England 03-08-2015
Subjects:
Animals
Autoimmune Diseases - immunology
Cytokines - metabolism
Epithelial Cells - immunology
Homeostasis
Humans
Hypersensitivity - immunology
Immunity, Innate
Inflammation - immunology
Lymphocytes - immunology
Receptors, Pattern Recognition - metabolism
disease
immunity
innate lymphoid cells
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Summary:Innate lymphoid cells (ILCs) are lymphoid cells that do not express V(D)J-rearranged receptors and play a role in the innate immune system. ILCs are categorized into three groups with respect to their function in the immune system. ILC1 induces production of IFN-γ via T-box expressed on T cells, ILC2 promotes production of type 2 cytokines via GATA-binding protein-3 and ILC3 promotes IL-17 and IL-22 production via retinoic acid receptor-related orphan receptor-γt. ILCs can maintain homeostasis in epithelial surfaces by responding to locally produced cytokines or direct recognition of danger patterns. Altered epithelial barrier function seems to be a key point in inappropriate activation of ILCs to promote inflammatory and allergic responses. ILCs play an essential role in initiation and maintenance of defense against infections as well as immune-mediated diseases. In this paper, we discuss the role of ILCs in inflammatory, allergic and autoimmune diseases.
ISSN:1744-8409
DOI:10.1586/1744666x.2015.1050382