Search Results - "Baranowski, Bradley J"

Examination of BDNF Treatment on BACE1 Activity and Acute Exercise on Brain BDNF Signaling by Baranowski, Bradley J, Hayward, Grant C, Marko, Daniel M, MacPherson, Rebecca E K

“…Perturbations in metabolism results in the accumulation of beta-amyloid peptides, which is a pathological feature of Alzheimer's disease. Beta-site amyloid…”
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Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4‐weeks of sprint interval training in young men with obesity by Kurgan, Nigel, Islam, Hashim, Matusiak, Jennifer B. L., Baranowski, Bradley J., Stoikos, Joshua, Fajardo, Val A., MacPherson, Rebecca E. K., Gurd, Brendon J., Klentrou, Panagiota

“…Sclerostin is a Wnt/β‐catenin antagonist, mainly secreted by osteocytes, and most known for its role in reducing bone formation. Studies in rodents suggest…”
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Characterization of Alzheimer's disease‐like neuropathology in Duchenne's muscular dystrophy using the DBA/2J mdx mouse model by Hayward, Grant C., Caceres, Daniela, Copeland, Emily N., Baranowski, Bradley J., Mohammad, Ahmad, Whitley, Kennedy C., Fajardo, Val A., MacPherson, Rebecca E. K.

“…Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder caused by a mutation in the dystrophin gene. In addition to muscle pathology, some…”
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Interleukin-6 Treatment Results in GLUT4 Translocation and AMPK Phosphorylation in Neuronal SH-SY5Y Cells by Marko, Daniel M, Foran, Gregory, Vlavcheski, Filip, Baron, David C, Hayward, Grant C, Baranowski, Bradley J, Necakov, Aleksander, Tsiani, Evangelia, MacPherson, Rebecca E K

“…Interleukin-6 (IL-6) is a pleiotropic cytokine that can be released from the brain during prolonged exercise. In peripheral tissues, exercise induced IL-6 can…”
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Cerebrovascular insufficiency and amyloidogenic signaling in Ossabaw swine with cardiometabolic heart failure by Baranowski, Bradley J, Allen, Matti D, Nyarko, Jennifer Nk, Rector, R Scott, Padilla, Jaume, Mousseau, Darrell D, Rau, Christoph D, Wang, Yibin, Laughlin, M Harold, Emter, Craig A, MacPherson, Rebecca Ek, Olver, T Dylan

“…Individuals with heart failure (HF) frequently present with comorbidities, including obesity, insulin resistance, hypertension, and dyslipidemia. Many patients…”
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GDF15 Associates with, but is not Responsible for, Exercise-Induced Increases in Corticosterone and Indices of Lipid Utilization in Mice by Arbeau, Meagan, Baranowski, Bradley J, Jeromson, Stewart, Bellucci, Annalaura, Akcan, Michael, Trang, Serena, Eisner, Katelyn, Medak, Kyle D, Wright, David C

“…Growth differentiation factor 15 (GDF15) is a stress-induced cytokine that increases with exercise and is thought to increase corticosterone and lipid…”
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Exercise training and BDNF injections alter amyloid precursor protein (APP) processing enzymes and improve cognition by Baranowski, Bradley J, Mohammad, Ahmad, Finch, Michael S, Brown, Alex, Dhaliwal, Roopan, Marko, Daniel M, LeBlanc, Paul J, McCormick, Cheryl M, Fajardo, Val A, MacPherson, Rebecca E K

“…Exercise reduces cognitive aging, neurodegeneration, and Alzheimer's disease (AD) risk. Acute exercise reduces the activity of β-site amyloid precursor…”
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Sclerostin Influences Exercise‐Induced Adaptations in Body Composition and White Adipose Tissue Morphology in Male Mice by Kurgan, Nigel, Stoikos, Joshua, Baranowski, Bradley J., Yumol, Jenalyn, Dhaliwal, Roopan, Sweezey‐Munroe, Jake B., Fajardo, Val A., Gittings, William, Macpherson, Rebecca E.K., Klentrou, Panagiota

“…ABSTRACT Sclerostin is an inhibitor of the osteogenic Wnt/β‐catenin signaling pathway that also has an endocrine role in regulating adipocyte differentiation…”
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Acute exercise induced BDNF-TrkB signalling is intact in the prefrontal cortex of obese, glucose-intolerant male mice by Baranowski, Bradley J, MacPherson, Rebecca E K

“…Obesity and glucose intolerance have been directly implicated in the pathology of Alzheimer's disease. It is thought that diet-induced obesity causes a…”
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Examining the effects of ovarian hormone loss and diet-induced obesity on Alzheimer's disease markers of amyloid-β production and degradation by Hayward, Grant C, Baranowski, Bradley J, Marko, Daniel M, MacPherson, Rebecca E K

“…After menopause, women experience declines in ovarian sex hormones, an event that has recently been associated with increased amyloid-β peptides, a main…”
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New Insights on the Role of Residue 673 of APP in Alzheimer's Disease by Mueller, Matthew C, Baranowski, Bradley J, Hayward, Grant C

“…Mueller et al offer their insights on the role of residue 673 of APP in Alzheimer's disease. They cite a study that investigated whether APPrIta led to…”
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Kynurenine metabolism is altered in mdx mice: a potential muscle to brain connection by Copeland, Emily N., Watson, Colton J. F., Whitley, Kennedy C., Baranowski, Bradley J., Kurgan, Nigel, MacNeil, Adam J., MacPherson, Rebecca E. K., Fajardo, Val A., Allison, David J.

“…New Findings What is the central question in this study? Promoting muscle health with regular aerobic exercise can improve mental health through a kynurenine…”
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Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL/6J mice by Bott, Kirsten N., Gittings, William, Fajardo, Val Andrew, Baranowski, Bradley J., Vandenboom, Rene, LeBlanc, Paul J., Ward, Wendy E., Peters, Sandra J.

“…Scope The effects of a long‐term high fat and sucrose diet (HFS) superimposed with aging on bone and muscle structure and/or function. Methods and results Male…”
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Evaluation of neuropathological effects of a high‐fat high‐sucrose diet in middle‐aged male C57BL6/J mice by Baranowski, Bradley J., Bott, Kirsten N., MacPherson, Rebecca E. K.

“…Metabolic dysfunction related to diet‐induced obesity has recently been linked to the pathogenesis of sporadic Alzheimer's disease (AD). However, the…”
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ESTROGEN LOSS INCREASES AMYLOIDOGENIC PROCESSING, WITH A HIGH FAT DIET EXACERBATING CHANGES IN MARKERS OF AMYLOID DEGRADATION IN C57BL6 FEMALE MICE by Hayward, Grant C., Baranowski, Bradley J., Marko, Danny M., MacPherson, Rebecca E.K.

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P3‐155: ROLE OF ACUTE EXERCISE‐INDUCED BRAIN BDNF ON APP PROCESSING AND BACE1 by Baranowski, Bradley J., Hayward, Grant C., Marko, Daniel M., MacPherson, Rebecca E.K.

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ROLE OF ACUTE EXERCISE-INDUCED BRAIN BDNF ON APP PROCESSING AND BACE1 by Baranowski, Bradley J., Hayward, Grant C., Marko, Daniel M., MacPherson, Rebecca E.K.

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P1‐157: ESTROGEN LOSS INCREASES AMYLOIDOGENIC PROCESSING, WITH A HIGH FAT DIET EXACERBATING CHANGES IN MARKERS OF AMYLOID DEGRADATION IN C57BL6 FEMALE MICE by Hayward, Grant C., Baranowski, Bradley J., Marko, Danny M., MacPherson, Rebecca E.K.

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Evidence of Increased Prefrontal Cortex Inflammation and Amyloid Precursor Protein Processing in a Translational Swine Model of Heart Failure with Preserved Ejection Fraction by Baranowski, Bradley J., Olver, T. Dylan, Edwards, Jenna C., Jurrisen, Tom J., Padilla, Jaume, Rector, R. Scott, Emter, Craig E., MacPherson, Rebecca EK

“…The oligomerization of amyloid beta peptides (Aβ), a histopathological hallmark of diseases such as Alzheimer's, may be elevated in cardiogenic dementias…”
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