Search Results - "Baranovski, Boris M"

Acute Phase Protein α₁-Antitrypsin Reduces the Bacterial Burden in Mice by Selective Modulation of Innate Cell Responses by Kaner, Ziv, Ochayon, David E., Shahaf, Galit, Baranovski, Boris M., Bahar, Nofar, Mizrahi, Mark, Lewis, Eli C.

“…Background. Severe bacterial infection can cause sepsis, multiple organ dysfunction syndrome (MODS), and death. Human α₁-antitrypsin (hAAT) is an…”
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Pancreatic islet xenograft survival in mice is extended by a combination of alpha-1-antitrypsin and single-dose anti-CD4/CD8 therapy by Ashkenazi, Efrat, Baranovski, Boris M, Shahaf, Galit, Lewis, Eli C

“…Clinical pancreatic islet transplantation is under evaluation for the treatment of autoimmune diabetes, yet several limitations preclude widespread use. For…”
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Point Mutation of a Non-Elastase-Binding Site in Human α1-Antitrypsin Alters Its Anti-Inflammatory Properties by Lior, Yotam, Zaretsky, Mariana, Ochayon, David E, Lotysh, Diana, Baranovski, Boris M, Schuster, Ronen, Guttman, Ofer, Aharoni, Amir, Lewis, Eli C

“…Human α1-antitrypsin (hAAT) is a 394-amino acid long anti-inflammatory, neutrophil elastase inhibitor, which binds elastase a sequence-specific molecular…”
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Experimental Support for the Ecoimmunity Theory: Distinct Phenotypes of Nonlymphocytic Cells in SCID and Wild-Type Mice by Ochayon, David E, Baranovski, Boris M, Malkin, Peter, Schuster, Ronen, Kalay, Noa, Ben-Hamo, Rotem, Sloma, Ido, Levinson, Justin, Brazg, Jared, Efroni, Sol, Lewis, Eli C, Nevo, Uri

“…Immune tolerance toward "self" is critical in multiple immune disorders. While there are several mechanisms to describe the involvement of immune cells in the…”
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Distinct anti-inflammatory properties of alpha1-antitrypsin and corticosteroids reveal unique underlying mechanisms of action by Schuster, Ronen, Motola-Kalay, Noa, Baranovski, Boris M., Bar, Liliana, Tov, Naveh, Stein, Michal, Lewis, Eli C., Ayalon, Michal, Sagiv, Yuval

“…•AAT results in cytokine shift to resolution as opposed to pan-suppression using Dex.•AAT requires intact NF-κB–p65 activity to amplify LPS-induced IL-1Ra…”
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Human α1-Antitrypsin Binds to Heat-Shock Protein gp96 and Protects from Endogenous gp96-Mediated Injury In vivo by Ochayon, David E, Mizrahi, Mark, Shahaf, Galit, Baranovski, Boris M, Lewis, Eli C

“…The extracellular form of the abundant heat-shock protein, gp96, is involved in human autoimmune pathologies. In patients with type 1 diabetes, circulating…”
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Diluted serum from calorie‐restricted animals promotes mitochondrial β‐cell adaptations and protect against glucolipotoxicity by Cerqueira, Fernanda M., Chausse, Bruno, Baranovski, Boris M., Liesa, Marc, Lewis, Eli C., Shirihai, Orian S., Kowaltowski, Alicia J.

“…β‐cells quickly adjust insulin secretion to oscillations in nutrients carried by the blood, acting as fuel sensors. However, most studies of β‐cell responses…”
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Diluted serum from calorie-restricted animals promotes mitochondrial [beta]-cell adaptations and protect against glucolipotoxicity by Cerqueira, Fernanda M, Chausse, Bruno, Baranovski, Boris M, Liesa, Marc, Lewis, Eli C, Shirihai, Orian S, Kowaltowski, Alicia J

“…[beta]-cells quickly adjust insulin secretion to oscillations in nutrients carried by the blood, acting as fuel sensors. However, most studies of [beta]-cell…”
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Alpha-1 Antitrypsin Substitution for Extrapulmonary Conditions in Alpha-1 Antitrypsin Deficient Patients by Baranovski, Boris M, Schuster, Ronen, Nisim, Omer, Brami, Ido, Lior, Yotam, Lewis, Eli C

“…Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder which most commonly manifests as pulmonary emphysema. Accordingly, alpha-1 antitrypsin (AAT)…”
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T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α1-Antitrypsin by Rider, Peleg, Lewis, Eli C., Freixo-Lima, Gabriella S., Baranovski, Boris M.

“…The traditional model of T helper differentiation describes the naïve T cell as choosing one of several subsets upon stimulation and an added reciprocal…”
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Human α1-antitrypsin attenuates injury-induced Inflammation through interacting with high mobility group box-1 (HMGB1) by Ohayon, David E, Schuster, Ronen, Mizrahi, Mark I, Lior, Yotam, Baranovski, Boris M, Shahaf, Galit, Lewis, Eli C

“…HMGB1 is involved in pathologies such as cellular injury and autoimmunity. Indeed, upon binding to immune-related receptors, HMGB1 promotes an inflammatory…”
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T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, α 1-Antitrypsin by Baranovski, Boris M., Freixo-Lima, Gabriella S., Lewis, Eli C., Rider, Peleg

“…The traditional model of T helper differentiation describes the naïve T cell as choosing one of several subsets upon stimulation and an added reciprocal…”
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T Helper Subsets, Peripheral Plasticity, and the Acute Phase Protein, [alpha]1-Antitrypsin by Baranovski, Boris M, Freixo-Lima, Gabriella S, Lewis, Eli C, Rider, Peleg

“…The traditional model of T helper differentiation describes the naïve T cell as choosing one of several subsets upon stimulation and an added reciprocal…”
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Pancreatic Islet Xenograft Survival in Mice Is Extended by a Combination of Alpha-1-Antitrypsin and Single-Dose Anti-CD4/CD8 Therapy. e63625 by Ashkenazi, Efrat, Baranovski, Boris M, Shahaf, Galit, Lewis, Eli C

“…Clinical pancreatic islet transplantation is under evaluation for the treatment of autoimmune diabetes, yet several limitations preclude widespread use. For…”
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