Search Results - "Baranov, Sergei V."

Two hit mitochondrial-driven model of synapse loss in neurodegeneration by Baranov, Sergei V., Jauhari, Abhishek, Carlisle, Diane L., Friedlander, Robert M.

“…In healthy neurons, a mitochondrial membrane potential gradient exists whereby membrane potential is highest in the soma and decreases with distance from the…”
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Inhibition of mitochondrial protein import by mutant huntingtin by Yano, Hiroko, Baranov, Sergei V, Baranova, Oxana V, Kim, Jinho, Pan, Yanchun, Yablonska, Svitlana, Carlisle, Diane L, Ferrante, Robert J, Kim, Albert H, Friedlander, Robert M

“…Mitochondrial dysfunction has been associated with Huntington's disease. The authors show that mutant huntingtin binds to the mitochondrial import protein…”
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Melatonin inhibits the caspase-1/cytochrome c /caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis by Zhang, Yi, Cook, Anna, Kim, Jinho, Baranov, Sergei V, Jiang, Jiying, Smith, Karen, Cormier, Kerry, Bennett, Erik, Browser, Robert P, Day, Arthur L, Carlisle, Diane L, Ferrante, Robert J, Wang, Xin, Friedlander, Robert M

“…Abstract Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1G93A transgenic mouse model of amyotrophic…”
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Mitochondria modulate programmed neuritic retraction by Baranov, Sergei V., Baranova, Oxana V., Yablonska, Svitlana, Suofu, Yalikun, Vazquez, Alberto L., Kozai, Takashi D. Y., Cui, X. Tracy, Ferrando, Lisa M., Larkin, Timothy M., Tyurina, Yulia Y., Kagan, Valerian E., Carlisle, Diane L., Kristal, Bruce S., Friedlander, Robert M.

“…Neuritic retraction in the absence of overt neuronal death is a shared feature of normal aging and neurodegenerative disorders, but the intracellular…”
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Systemic antimiR-337-3p delivery inhibits cerebral ischemia-mediated injury by Wang, Xiaomin, Suofu, Yalikun, Akpinar, Berkcan, Baranov, Sergei V, Kim, Jinho, Carlisle, Diane L, Zhang, Yu, Friedlander, Robert M

“…Abstract Modulation of miRNA expression has been shown to be beneficial in the context of multiple diseases. The purpose of this study was to determine if an…”
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Dietary macronutrients modulate the fatty acyl composition of rat liver mitochondrial cardiolipins[S] by Stavrovskaya, Irina G., Bird, Susan S., Marur, Vasant R., Sniatynski, Matthew J., Baranov, Sergei V., Greenberg, Heather K., Porter, Caryn L., Kristal, Bruce S.

“…The interaction of dietary fats and carbohydrates on liver mitochondria were examined in male FBNF1 rats fed 20 different low-fat isocaloric diets. Animal…”
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Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration by Jauhari, Abhishek, Baranov, Sergei V, Suofu, Yalikun, Kim, Jinho, Singh, Tanisha, Yablonska, Svitlana, Li, Fang, Wang, Xiaomin, Oberly, Patrick, Minnigh, M Beth, Poloyac, Samuel M, Carlisle, Diane L, Friedlander, Robert M

“…Chronic inflammation is a pathologic feature of neurodegeneration and aging; however, the mechanism regulating this process is not understood. Melatonin, an…”
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Kinetic Model for Ca2+-induced Permeability Transition in Energized Liver Mitochondria Discriminates between Inhibitor Mechanisms by Baranov, Sergei V., Stavrovskaya, Irina G., Brown, Abraham M., Tyryshkin, Alexei M., Kristal, Bruce S.

“…Cytotoxicity associated with pathophysiological Ca2+ overload (e.g. in stroke) appears mediated by an event termed the mitochondrial permeability transition…”
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Spectroscopic Evidence for Ca2+ Involvement in the Assembly of the Mn4Ca Cluster in the Photosynthetic Water-Oxidizing Complex by Tyryshkin, Alexei M, Watt, Richard K, Baranov, Sergei V, Dasgupta, Jyotishman, Hendrich, Michael P, Dismukes, G. Charles

“…Biogenesis and repair of the inorganic core (Mn4CaO x Cl y ), in the water-oxidizing complex of photosystem II (WOC−PSII), occurs through the light-induced…”
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Calcium controls the assembly of the photosynthetic water-oxidizing complex: a cadmium(II) inorganic mutant of the Mn4Ca core by Bartlett, John E, Baranov, Sergei V, Ananyev, Gennady M, Dismukes, G. Charles

“…bound to the ‘high-affinity’ site. Ca…”
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Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23 by Yablonska, Svitlana, Ganesan, Vinitha, Ferrando, Lisa M., Kim, JinHo, Pyzel, Anna, Baranova, Oxana V., Khattar, Nicolas K., Larkin, Timothy M., Baranov, Sergei V., Chen, Ning, Strohlein, Colleen E., Stevens, Donté A., Wang, Xiaomin, Chang, Yue-Fang, Schurdak, Mark E., Carlisle, Diane L., Minden, Jonathan S., Friedlander, Robert M.

“…Mutant huntingtin (mHTT), the causative protein in Huntington’s disease (HD), associates with the translocase of mitochondrial inner membrane 23 (TIM23)…”
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Biosynthesis of neuroprotective melatonin is dysregulated in Huntington's disease by Kim, Jinho, Li, Wei, Wang, Jingjing, Baranov, Sergei V, Heath, Brianna E, Jia, Jiaoying, Suofu, Yalikun, Baranova, Oxana V, Wang, Xiaomin, Larkin, Timothy M, Lariviere, William R, Carlisle, Diane L, Friedlander, Robert M

“…Huntington's disease (HD) is a progressive neurodegenerative brain disorder associated with uncontrolled body movements, cognitive decline, and reduced…”
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Bicarbonate Coordinates to Mn3+ during Photo-Assembly of the Catalytic Mn4Ca Core of Photosynthetic Water Oxidation: EPR Characterization by Dasgupta, Jyotishman, Tyryshkin, Alexei M., Baranov, Sergei V., Dismukes, G. Charles

“…Assembly of the catalytic cluster, Mn 4 CaO x Cl y , comprising the water-oxidizing complex (WOC) of photosystem II (PSII), occurs during biogenesis in the…”
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Melatonin inhibits cytosolic mitochondrial DNA-induced neuroinflammatory signaling in accelerated aging and neurodegeneration by Jauhari, Abhishek, Baranov, Sergei V, Suofu, Yalikun, Kim, Jinho, Singh, Tanisha, Yablonska, Svitlana, Li, Fang, Wang, Xiaomin, Oberly, Patrick, Minnigh, M Beth, Poloyac, Samuel M, Carlisle, Diane L, Friedlander, Robert M

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Cardiolipin signaling mechanisms: collapse of asymmetry and oxidation by Kagan, Valerian E, Tyurina, Yulia Y, Tyurin, Vladimir A, Mohammadyani, Dariush, Angeli, Jose Pedro Friedmann, Baranov, Sergei V, Klein-Seetharaman, Judith, Friedlander, Robert M, Mallampalli, Rama K, Conrad, Marcus, Bayir, Hülya

“…An ancient anionic phospholipid, cardiolipin (CL), ubiquitously present in prokaryotic and eukaryotic membranes, is essential for several structural and…”
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Isolation of functionally active and highly purified neuronal mitochondria from human cortex by Khattar, Nicolas K., Yablonska, Svitlana, Baranov, Sergei V., Baranova, Oxana V., Kretz, Eric S., Larkin, Timothy M., Carlisle, Diane L., Richardson, R. Mark, Friedlander, Robert M.

“…•Combined Percoll gradient centrifugation and anti-TOM22 magnetic bead extraction is used to isolate mitochondria.•The mitochondria obtained are neuronal (from…”
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Dipyrone Inhibits Neuronal Cell Death and Diminishes Hypoxic/Ischemic Brain Injury by Zhang, Yi, Wang, Xin, Baranov, Sergei V, Zhu, Shan, Huang, Zhihong, Fellows-Mayle, Wendy, Jiang, Jiying, Day, Arthur L, Kristal, Bruce S, Friedlander, Robert M

“…Abstract BACKGROUND: Dipyrone is an analgesic and antipyretic drug usually prescribed for patients with inflammatory conditions. We recently identified…”
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Isolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization by Gross, Vera S., Greenberg, Heather K., Baranov, Sergei V., Carlson, Greta M., Stavrovskaya, Irina G., Lazarev, Alexander V., Kristal, Bruce S.

“…Isolation of functional and intact mitochondria from solid tissue is crucial for studies that focus on the elucidation of normal mitochondrial physiology…”
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Reactive γ-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis by Stavrovskaya, Irina G., Baranov, Sergei V., Guo, Xiaofeng, Davies, Sean S., Roberts, L. Jackson, Kristal, Bruce S.

“…Isoketals (IsoKs) are γ-ketoaldehydes formed via the isoprostane pathway of arachidonic acid peroxidation and are among the most reactive by-products of lipid…”
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Dietary Omega-3 Fatty Acids Do Not Change Resistance of Rat Brain or Liver Mitochondria to Ca2+ and/or Prooxidants by Bird, Susan S., Stavrovskaya, Irina G., Marur, Vasant R., Baranov, Sergei V., Greenberg, Heather K., Porter, Caryn L., Kristal, Bruce S.

“…Omega-3 polyunsaturated fatty acids (n-3 PUFAs) block apoptotic neuronal cell death and are strongly neuroprotective in acute and chronic neurodegeneration…”
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