Search Results - "Baranauskiene, Lina"

Phenotypic characterization of Gardnerella vaginalis subgroups suggests differences in their virulence potential by Janulaitiene, Migle, Gegzna, Vilmantas, Baranauskiene, Lina, Bulavaitė, Aistė, Simanavicius, Martynas, Pleckaityte, Milda

“…The well-known genotypic and phenotypic diversity of G. vaginalis resulted in its classification into at least four subgroups (clades) with diverse genomic…”
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Inerolysin and vaginolysin, the cytolysins implicated in vaginal dysbiosis, differently impair molecular integrity of phospholipid membranes by Ragaliauskas, Tadas, Plečkaitytė, Milda, Jankunec, Marija, Labanauskas, Linas, Baranauskiene, Lina, Valincius, Gintaras

“…The pore-forming toxins, inerolysin (INY) and vaginolysin (VLY), produced by vaginal bacteria Lactobacillus iners and Gardnerella vaginalis were studied using…”
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Isothermal titration calorimetry for characterization of recombinant proteins by Baranauskiene, Lina, Kuo, Tai-Chih, Chen, Wen-Yih, Matulis, Daumantas

“…[Display omitted] •ITC quantitatively determines the purity of recombinantly produced proteins.•Protein capability of binding a specific ligand is observed in…”
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A standard operating procedure for an enzymatic activity inhibition assay by Smirnovienė, Joana, Baranauskienė, Lina, Zubrienė, Asta, Matulis, Daumantas

“…This Standard Operating Protocol (SOP) describes the key steps of experimental setup for an inhibition assay of enzymatic activity. The protocol begins with…”
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S100A9 Alters the Pathway of Alpha-Synuclein Amyloid Aggregation by Toleikis, Zigmantas, Ziaunys, Mantas, Baranauskiene, Lina, Petrauskas, Vytautas, Jaudzems, Kristaps, Smirnovas, Vytautas

“…The formation of amyloid fibril plaques in the brain creates inflammation and neuron death. This process is observed in neurodegenerative disorders, such as…”
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Thiazide and other Cl-benzenesulfonamide-bearing clinical drug affinities for human carbonic anhydrases by Baranauskiene, Lina, Škiudaitė, Lina, Michailovienė, Vilma, Petrauskas, Vytautas, Matulis, Daumantas

“…Twelve carbonic anhydrase (CA) isoforms catalyze carbon dioxide hydration to bicarbonate and acid protons and are responsible for many biological functions in…”
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Inhibitory Monoclonal Antibodies and Their Recombinant Derivatives Targeting Surface-Exposed Carbonic Anhydrase XII on Cancer Cells by Stravinskiene, Dovile, Sliziene, Aiste, Baranauskiene, Lina, Petrikaite, Vilma, Zvirbliene, Aurelija

“…Monoclonal and recombinant antibodies are widely used for the diagnostics and therapy of cancer. They are generated to interact with cell surface proteins…”
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Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform by Wagner, Tobias, Greschik, Holger, Burgahn, Teresa, Schmidtkunz, Karin, Schott, Anne-Kathrin, McMillan, Joel, Baranauskienė, Lina, Xiong, Yan, Fedorov, Oleg, Jin, Jian, Oppermann, Udo, Matulis, Daumantas, Schüle, Roland, Jung, Manfred

“…Epigenetic modifications of histone tails play an essential role in the regulation of eukaryotic transcription. Writer and eraser enzymes establish and…”
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Thermodynamic, kinetic, and structural parameterization of human carbonic anhydrase interactions toward enhanced inhibitor design by Linkuvienė, Vaida, Zubrienė, Asta, Manakova, Elena, Petrauskas, Vytautas, Baranauskienė, Lina, Zakšauskas, Audrius, Smirnov, Alexey, Gražulis, Saulius, Ladbury, John E, Matulis, Daumantas

“…The aim of rational drug design is to develop small molecules using a quantitative approach to optimize affinity. This should enhance the development of…”
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POT1 stability and binding measured by fluorescence thermal shift assays by DeLeeuw, Lynn W, Monsen, Robert C, Petrauskas, Vytautas, Gray, Robert D, Baranauskiene, Lina, Matulis, Daumantas, Trent, John O, Chaires, Jonathan B

“…The protein POT1 (Protection of Telomeres 1) is an integral part of the shelterin complex that protects the ends of human chromosomes from degradation or end…”
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Titration calorimetry standards and the precision of isothermal titration calorimetry data by Baranauskiene, Lina, Petrikaite, Vilma, Matuliene, Jurgita, Matulis, Daumantas

“…Current Isothermal Titration Calorimetry (ITC) data in the literature have relatively high errors in the measured enthalpies of protein-ligand binding…”
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Biochemical Characterization of CA IX, One of the Most Active Carbonic Anhydrase Isozymes by Hilvo, Mika, Baranauskiene, Lina, Salzano, Anna Maria, Scaloni, Andrea, Matulis, Daumantas, Innocenti, Alessio, Scozzafava, Andrea, Monti, Simona Maria, Di Fiore, Anna, De Simone, Giuseppina, Lindfors, Mikaela, Jänis, Janne, Valjakka, Jarkko, Pastoreková, Silvia, Pastorek, Jaromir, Kulomaa, Markku S., Nordlund, Henri R., Supuran, Claudiu T., Parkkila, Seppo

“…Carbonic anhydrase IX (CA IX) is an exceptional member of the CA protein family; in addition to its classical role in pH regulation, it has also been proposed…”
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Looking for a generic inhibitor of amyloid-like fibril formation among flavone derivatives by Šneideris, Tomas, Baranauskienė, Lina, Cannon, Jonathan G, Rutkienė, Rasa, Meškys, Rolandas, Smirnovas, Vytautas

“…A range of diseases is associated with amyloid fibril formation. Despite different proteins being responsible for each disease, all of them share similar…”
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Novel fluorinated carbonic anhydrase IX inhibitors reduce hypoxia-induced acidification and clonogenic survival of cancer cells by Kazokaitė, Justina, Niemans, Raymon, Dudutienė, Virginija, Becker, Holger M, Leitāns, Jānis, Zubrienė, Asta, Baranauskienė, Lina, Gondi, Gabor, Zeidler, Reinhard, Matulienė, Jurgita, Tārs, Kaspars, Yaromina, Ala, Lambin, Philippe, Dubois, Ludwig J, Matulis, Daumantas

“…Human carbonic anhydrase (CA) IX has emerged as a promising anticancer target and a diagnostic biomarker for solid hypoxic tumors. Novel fluorinated CA IX…”
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From X-ray crystallographic structure to intrinsic thermodynamics of protein-ligand binding using carbonic anhydrase isozymes as a model system by Paketurytė-Latvė, Vaida, Smirnov, Alexey, Manakova, Elena, Baranauskiene, Lina, Petrauskas, Vytautas, Zubrienė, Asta, Matulienė, Jurgita, Dudutienė, Virginija, Čapkauskaitė, Edita, Zakšauskas, Audrius, Leitans, Janis, Gražulis, Saulius, Tars, Kaspars, Matulis, Daumantas

“…Carbonic anhydrase (CA) was among the first proteins whose X-ray crystal structure was solved to atomic resolution. CA proteins have essentially the same fold…”
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Purification, enzymatic activity and inhibitor discovery for recombinant human carbonic anhydrase XIV by Juozapaitienė, Vaida, Bartkutė, Brigita, Michailovienė, Vilma, Zakšauskas, Audrius, Baranauskienė, Lina, Satkūnė, Sandra, Matulis, Daumantas

“…•Recombinant preparation of CA XIV, a difficult to produce protein, is described.•Large amount of CA XIV was affinity purified using sulfonamide-modified…”
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Measurement of nanomolar dissociation constants by titration calorimetry and thermal shift assay - radicicol binding to Hsp90 and ethoxzolamide binding to CAII by Zubriene, Asta, Matuliene, Jurgita, Baranauskiene, Lina, Jachno, Jelena, Torresan, Jolanta, Michailoviene, Vilma, Cimmperman, Piotras, Matulis, Daumantas

“…The analysis of tight protein-ligand binding reactions by isothermal titration calorimetry (ITC) and thermal shift assay (TSA) is presented. The binding of…”
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Intrinsic thermodynamics of ethoxzolamide inhibitor binding to human carbonic anhydrase XIII by Baranauskienė, Lina, Matulis, Daumantas

“…Human carbonic anhydrases (CAs) play crucial role in various physiological processes including carbon dioxide and hydrocarbon transport, acid homeostasis,…”
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Indapamide-like benzenesulfonamides as inhibitors of carbonic anhydrases I, II, VII, and XIII by Čapkauskaitė, Edita, Baranauskienė, Lina, Golovenko, Dmitrij, Manakova, Elena, Gražulis, Saulius, Tumkevičius, Sigitas, Matulis, Daumantas

“…A series of novel 2-chloro-5-[(1-benzimidazolyl- and 2-benzimidazolylsulfanyl)acetyl]benzene-sulfonamides were designed and synthesized. Their binding to…”
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Design of [(2-pyrimidinylthio)acetyl]benzenesulfonamides as inhibitors of human carbonic anhydrases by Čapkauskaitė, Edita, Zubrienė, Asta, Baranauskienė, Lina, Tamulaitienė, Giedrė, Manakova, Elena, Kairys, Visvaldas, Gražulis, Saulius, Tumkevičius, Sigitas, Matulis, Daumantas

“…A series of [(2-pyrimidinylthio)acetyl]benzenesulfonamides were designed and synthesized. Their binding affinities as inhibitors of several recombinant human…”
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