Search Results - "Baraldi, PG"

Transient receptor potential ankyrin receptor 1 is a novel target for pro‐tussive agents by Andrè, E, Gatti, R, Trevisani, M, Preti, D, Baraldi, PG, Patacchini, R, Geppetti, P

“…Background and purpose:  The transient receptor potential ankyrin receptor 1 (TRPA1) is a cation channel, co‐expressed with the pro‐tussive transient receptor…”
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Medicinal Chemistry, Pharmacology, and Clinical Implications of TRPV1 Receptor Antagonists by Aghazadeh Tabrizi, Mojgan, Baraldi, Pier Giovanni, Baraldi, Stefania, Gessi, Stefania, Merighi, Stefania, Borea, Pier Andrea

“…Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory neurons triggering an influx of cations. TRPV1 receptors function as…”
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Medicinal Chemistry of A3 Adenosine Receptor Modulators: Pharmacological Activities and Therapeutic Implications by Baraldi, Pier Giovanni, Preti, Delia, Borea, Pier Andrea, Varani, Katia

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DNA minor groove binders as potential antitumor and antimicrobial agents by Baraldi, Pier Giovanni, Bovero, Andrea, Fruttarolo, Francesca, Preti, Delia, Tabrizi, Mojgan Aghazadeh, Pavani, Maria Giovanna, Romagnoli, Romeo

“…DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form noncovalent complexes with DNA (e.g.,…”
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A glance at adenosine receptors: novel target for antitumor therapy by Merighi, Stefania, Mirandola, Prisco, Varani, Katia, Gessi, Stefania, Leung, Edward, Baraldi, Pier Giovanni, Tabrizi, Mojgan Aghazadeh, Borea, Pier Andrea

“…Adenosine can be released from a variety of cells throughout the body, as the result of increased metabolic rates, in concentrations that can have a profound…”
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Adenosine Receptors as Mediators of Both Cell Proliferation and Cell Death of Cultured Human Melanoma Cells by Merighi, Stefania, Mirandola, Prisco, Milani, Daniela, Varani, Katia, Gessi, Stefania, Klotz, Karl-Norbert, Leung, Edward, Baraldi, Pier Giovanni, Borea, Pier Andrea

“…Adenosine displays contradictory effects on cell growth: it improves cell proliferation, but it may also induce apoptosis and impair cell survival. Following…”
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Antimicrobial and antitumor activity of n-heteroimmine-1,2,3-dithiazoles and their transformation in triazolo-, imidazo-, and pyrazolopirimidines by Baraldi, Pier Giovanni, Pavani, Maria Giovanna, Nuñez, Maria del Carmen, Brigidi, Patrizia, Vitali, Beatrice, Gambari, Roberto, Romagnoli, Romeo

“…The reaction of Appel's salt with o-amino nitrile heterocycles 10– 19 gave the corresponding 4-chloro-5-heteroimmine-1,2,3-dithiazoles 20– 29 which were…”
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Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containing α-Methylene-γ-butyrolactones and Polypyrrole Minor Groove Binders by Baraldi, Pier Giovanni, del Carmen Nunez, Maria, Tabrizi, Mojgan Aghazadeh, De Clercq, Erik, Balzarini, Jan, Bermejo, Jaime, Estévez, Francisco, Romagnoli, Romeo

“…We have synthesized and evaluated a series of hybrids of polypyrrole minor groove binders structurally related to the natural antitumor agent distamycin A, and…”
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A(3) adenosine receptors in human neutrophils and promyelocytic HL60 cells: a pharmacological and biochemical study by Gessi, Stefania, Varani, Katia, Merighi, Stefania, Cattabriga, Elena, Iannotta, Valeria, Leung, Edward, Baraldi, Pier Giovanni, Borea, Pier Andrea

“…This work compares the pharmacological and biochemical properties of A(3) adenosine receptors in human polymorphonuclear neutrophil granulocytes (PMNs) and…”
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[(3)H]MRE 3008F20: a novel antagonist radioligand for the pharmacological and biochemical characterization of human A(3) adenosine receptors by Varani, K, Merighi, S, Gessi, S, Klotz, K N, Leung, E, Baraldi, P G, Cacciari, B, Romagnoli, R, Spalluto, G, Borea, P A

“…The lack of a radiolabeled selective A(3) adenosine receptor antagonist is a major drawback for an adequate characterization of this receptor subtype. This…”
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Synthesis of new pyrazolo[4,3- e]-1,2,4-triazolo[1,5- c]pyrimidines and related heterocycles by Baraldi, Pier Giovanni, El-Kashef, Hussein, Farghaly, Abdel-Rahman, Vanelle, Patrice, Fruttarolo, Francesca

“…The reaction between 5-amino-4-imino-1(2)-substituted-1(2) H-4,5-dihydropyrazolo[3,4- d]pyrimidines and several commercially available reactants afforded new…”
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A(3) adenosine receptor ligands: history and perspectives by Baraldi, P G, Cacciari, B, Romagnoli, R, Merighi, S, Varani, K, Borea, P A, Spalluto, G

“…Adenosine regulates many physiological functions through specific cell membrane receptors. On the basis of pharmacological studies and molecular cloning, four…”
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Synthesis, Biological Activity, and Molecular Modeling Investigation of New Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Human A3 Adenosine Receptor Antagonists by Baraldi, Pier Giovanni, Cacciari, Barbara, Moro, Stefano, Spalluto, Giampiero, Pastorin, Giorgia, Da Ros, Tatiana, Klotz, Karl-Norbert, Varani, Katia, Gessi, Stefania, Borea, Pier Andrea

“…A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl moieties at the N5 position, being highly potent and…”
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New potent and selective human adenosine A(3) receptor antagonists by Baraldi, P G, Borea, P A

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Cytotoxic α-Halogenoacrylic Derivatives of Distamycin A and Congeners by Beria, Italo, Baraldi, Pier Giovanni, Cozzi, Paolo, Caldarelli, Marina, Geroni, Cristina, Marchini, Sergio, Mongelli, Nicola, Romagnoli, Romeo

“…The mechanism of action of many antitumor agents involves DNA damage, either by direct binding of the drug to DNA or to DNA-binding proteins. However, most of…”
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Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containing α-Methylene-γ-Butyrolactones and α-Bromoacryloyl Moieties by Romagnoli, Romeo, Baraldi, Pier Giovanni, Tabrizi, Mojgan Aghazadeh, Bermejo, Jaime, Estévez, Francisco, Borgatti, Monica, Gambari, Roberto

“…The synthesis and biological activity of hybrids 8 − 18 prepared combining α-methylene-γ-butyrolactones and α-bromoacryloylamides have been described and their…”
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Pyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine Derivatives as Highly Potent and Selective Human A3 Adenosine Receptor Antagonists:  Influence of the Chain at the N8 Pyrazole Nitrogen by Baraldi, Pier Giovanni, Cacciari, Barbara, Romagnoli, Romeo, Spalluto, Giampiero, Moro, Stefano, Klotz, Karl-Norbert, Leung, Edward, Varani, Katia, Gessi, Stefania, Merighi, Stefania, Borea, Pier Andrea

“…An enlarged series of pyrazolotriazolopyrimidines previously reported, in preliminary form (Baraldi et al. J. Med. Chem. 1999, 42, 4473−4478), as highly potent…”
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Synthesis, biological properties, and molecular modeling investigation of the first potent, selective, and water-soluble human A(3) adenosine receptor antagonist by Maconi, Anna, Pastorin, Giorgia, Da Ros, Tatiana, Spalluto, Giampiero, Gao, Zhan-Guo, Jacobson, Kenneth A, Baraldi, Pier Giovanni, Cacciari, Barbara, Varani, Katia, Moro, Stefano, Borea, Pier Andrea

“…A new, highly potent, selective, and water-soluble antagonist of the hA(3) adenosine receptor was synthesized and tested in binding and functional assays…”
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Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography by Todde, S, Moresco, R M, Simonelli, P, Baraldi, P G, Cacciari, B, Spalluto, G, Varani, K, Monopoli, A, Matarrese, M, Carpinelli, A, Magni, F, Kienle, M G, Fazio, F

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Pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine derivatives as highly potent and selective human A(3) adenosine receptor antagonists by Baraldi, P G, Cacciari, B, Romagnoli, R, Spalluto, G, Klotz, K N, Leung, E, Varani, K, Gessi, S, Merighi, S, Borea, P A

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