Search Results - "Barakat, Farah M."

Roles for NK Cells and an NK Cell-Independent Source of Intestinal Gamma Interferon for Innate Immunity to Cryptosporidium parvum Infection by Barakat, Farah M, McDonald, Vincent, Di Santo, James P, Korbel, Daniel S

“…A gamma interferon (IFN-γ)-dependent innate immune response operates against the intestinal parasite Cryptosporidium parvum in T- and B-cell-deficient SCID…”
Get full text

Cryptosporidium parvum Infection Rapidly Induces a Protective Innate Immune Response Involving Type I Interferon by Barakat, Farah M., McDonald, Vincent, Foster, Graham R., Tovey, Michael G., Korbel, Daniel S.

“…Type II interferon (IFN), IFN-γ, is important in innate immunity to the intestinal protozoan parasite Cryptosporidium species, which infects epithelial cells…”
Get full text

CD4⁺ T Cells Are Not Essential for Control of Early Acute Cryptosporidium parvum Infection in Neonatal Mice by Korbel, Daniel S, Barakat, Farah M, Di Santo, James P, McDonald, Vincent

“…Cryptosporidiosis is an important diarrheal disease of humans and neonatal livestock caused by Cryptosporidium spp. that infect epithelial cells. Recovery from…”
Get full text

Incidence and Prevalence of Paediatric Inflammatory Bowel Disease Continues to Increase in the South of England by Ashton, James J., Barakat, Farah M., Barnes, Claire, Coelho, Tracy A.F., Batra, Akshay, Afzal, Nadeem A., Beattie, R. Mark

“…Objective: The incidence of paediatric inflammatory bowel disease (IBD) has been increasing over 25 years; however, contemporary trends are not established and…”
Get full text

Transcriptomic profiling reveals a pronociceptive role for angiotensin II in inflammatory bowel disease by Higham, James P, Bhebhe, Charity N, Gupta, Rohit A, Tranter, Michael M, Barakat, Farah M, Dogra, Harween, Bab, Natalie, Wozniak, Eva, Barker, Katie H, Wilson, Catherine H, Mein, Charles A, Raine, Tim, Cox, James J, Wood, John N, Croft, Nicholas M, Wright, Paul D, Bulmer, David C

“…Visceral pain is a leading cause of morbidity in inflammatory bowel disease (IBD), contributing significantly to reduced quality of life. Currently available…”
Get full text

Item Generation and Reduction Toward Developing a Patient‐reported Outcome for Pediatric Ulcerative Colitis (TUMMY‐UC) by Marcovitch, Liron, Nissan, Anat, Mack, David, Otley, Anthony, Hussey, Seamus, Mclean, Beth, Lewis, Mary, Croft, Nick, Barakat, Farah M., Griffiths, Anne M., Turner, Dan

“…ABSTRACT Background: The Pediatric Ulcerative Colitis Activity Index (PUCAI) is a noninvasive clinician‐based index, which reflects disease severity in…”
Get full text

Oral Iron Treatment Response and Predictors in Anaemic Adolescents and Adults with IBD: A Prospective Controlled Open-Label Trial by Rampton, David S., Goodhand, James R., Joshi, Neerav M., Karim, Abu-Bakarr, Koodun, Yasmine, Barakat, Farah M., Macken, Lucia, Ward, Douglas G., Iqbal, Tariq H., Epstein, Jenny, Fell, John M., Sanderson, Ian R.

“…Abstract Background: Because of previous concerns about the efficacy and safety of oral iron for treating iron deficiency anaemia in inflammatory bowel disease…”
Get full text

Assessing the feasibility of injectable growth-promoting therapy in Crohn's disease by Altowati, Mabrouka A, Jones, Ashley P, Hickey, Helen, Williamson, Paula R, Barakat, Farah M, Plaatjies, Nicolene C, Hardwick, Ben, Russell, Richard K, Jaki, Thomas, Ahmed, S Faisal, Sanderson, Ian R

“…Despite optimal therapy, many children with Crohn's disease (CD) experience growth retardation. The objectives of the study are to assess the feasibility of a…”
Get full text

Incidence and prevalence of paediatric inflammatory bowel disease continues to increase in the south of England by Ashton, James J, Barakat, Farah M, Barnes, Claire, Coelho, Tracy AF, Batra, Akshay, Afzal, Nadeem A, Beattie, R Mark

Get full text

G21 Overlapping clinical profiles when juvenile dermatomyositis presents with coeliac disease by Lucier, Rebecca, Barakat, Farah M, Hall, Tara, Main, Cheryl, Leahy, Alice, Nott, Kerstin, Coelho, Tracy

“…Introduction/BackgroundCo-existing immune-mediated conditions including juvenile dermatomyositis (JDM) are well described in coeliac disease. Both conditions…”
Get full text

G9 Atypical presentation of coeliac disease with acute onset generalized oedema and hypoalbuminemia, but no GI symptoms by Barakat, Farah M, Ghattas, Sylvia, Vadgama, Bhumita, Lawrenson, David, Beattie, Mark, Coelho, Tracy

“…Background/IntroductionCoeliac disease (CD) is a chronic immune-mediated disease of the small intestine that occurs in genetically susceptible individuals,…”
Get full text

P60 Ustekinumab is an effective drug for steroid-free remission in children with refractory IBD and anti TNF-alpha induced psoriasis by Barakat, Farah M, Barnes, Claire, Baker, Jonathan, Batra, Akshay, Afzal, Nadeem A, Mark Beattie, R, Coelho, Tracy A

“…BackgroundManagement of paediatric Crohn’s disease (CD) presents significant challenges. Escalation of therapy to biologics or a ‘top-down’ approach, with…”
Get full text

IBD 3 Weight-based prescribing of thiopurines may not accurately optimise metabolite levels in the safe and therapeutic range: a paediatric IBD study by Barakat, Farah M, Lewis, Sophie, Ashton, James, Gilbert, Luke, Driscoll, Kouros, Barnes, Claire, Sholeye-Bolaji, Adebola, Phan, Hang, Cheng, Guo, Haggarty, Rachel, Batra, Akshay, Afzal, Nadeem A, Mark Beattie, R, Ennis, Sarah, Coelho, Tracy

“…BackgroundThiopurine drugs have been widely used in the treatment of IBD for several decades. In recent years, a better understanding of thiopurine metabolism…”
Get full text