Search Results - "Barak, Dov"

Identification by Site-directed Mutagenesis of Residues Involved in Ligand Recognition and Activation of the Human A3 Adenosine Receptor by Gao, Zhan-Guo, Chen, Aishe, Barak, Dov, Kim, Soo-Kyung, Müller, Christa E., Jacobson, Kenneth A.

“…Ligand recognition has been extensively explored in G protein-coupled A1, A2A, and A2B adenosine receptors but not in the A3receptor, which is…”
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Crystal Structures of Aged Phosphonylated Acetylcholinesterase:  Nerve Agent Reaction Products at the Atomic Level by Millard, Charles B, Kryger, Gitay, Ordentlich, Arie, Greenblatt, Harry M, Harel, Michal, Raves, Mia L, Segall, Yoffi, Barak, Dov, Shafferman, Avigdor, Silman, Israel, Sussman, Joel L

“…Organophosphorus acid anhydride (OP) nerve agents are potent inhibitors which rapidly phosphonylate acetylcholinesterase (AChE) and then may undergo an…”
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Functional Characteristics of the Oxyanion Hole in Human Acetylcholinesterase by Ordentlich, Arie, Barak, Dov, Kronman, Chanoch, Ariel, Naomi, Segall, Yoffi, Velan, Baruch, Shafferman, Avigdor

“…The contribution of the oxyanion hole to the functional architecture and to the hydrolytic efficiency of human acetylcholinesterase (HuAChE) was investigated…”
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Constitutive Activation of A3 Adenosine Receptors by Site-Directed Mutagenesis by Chen, Aishe, Gao, Zhan-Guo, Barak, Dov, Liang, Bruce T., Jacobson, Kenneth A.

“…The objective of this study was to create constitutively active mutant human A3 adenosine receptors (ARs) using single amino acid replacements, based on…”
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The Architecture of Human Acetylcholinesterase Active Center Probed by Interactions with Selected Organophosphate Inhibitors by Ordentlich, Arie, Barak, Dov, Kronman, Chanoch, Ariel, Naomi, Segall, Yoffi, Velan, Baruch, Shafferman, Avigdor

“…The role of the functional architecture of human acetylcholinesterase (HuAChE) active center in facilitating reactions with organophosphorus inhibitors was…”
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Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase (∗) by Ordentlich, Arie, Barak, Dov, Kronman, Chanoch, Ariel, Naomi, Segall, Yoffi, Velan, Baruch, Shafferman, Avigdor

“…Substitution of Trp-86, in the active center of human acetylcholinesterase (HuAChE), by aliphatic but not by aromatic residues resulted in a several…”
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Evaluation of Homology Modeling of G-Protein-Coupled Receptors in Light of the A2A Adenosine Receptor Crystallographic Structure by Ivanov, Andrei A, Barak, Dov, Jacobson, Kenneth A

“…Homology modeling of the human A2A adenosine receptor (AR) based on bovine rhodopsin predicted a protein structure that was very similar to the recently…”
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Evaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure by Ivanov, Andrei A, Barak, Dov, Jacobson, Kenneth A

“…Homology modeling of the human A(2A) adenosine receptor (AR) based on bovine rhodopsin predicted a protein structure that was very similar to the recently…”
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Carbocation-Mediated Processes in Biocatalysts. Contribution of Aromatic Moieties by Barak, Dov, Ordentlich, Arie, Segall, Yoffi, Velan, Baruch, Benschop, Hendrik P, De Jong, Leo P. A, Shafferman, Avigdor

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A preliminary comparison of structural models for catalytic intermediates of acetylcholinesterase by Silman, Israel, Millard, Charles B., Ordentlich, Arie, Greenblatt, Harry M., Harel, Michal, Barak, Dov, Shafferman, Avigdor, Sussman, Joel L.

“…Determination of the three dimensional structure of Torpedo Californica acetylcholinesterase (TcAChE) provided an experimental tool for directly visualizing…”
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Ligand-G Protein Allosteric Communication through Internal Waters in GPCR Complexes by Osman, Roman, Gomez, Jose Carlos, Mezei, Mihaly, Barak, Dov, Cordomi, Arnau, Pardo, Leonardo

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The Role of Internal Water in GPCR Complexes by Osman, Roman, Mezei, Mihaly, Barak, Dov, Cordomi, Arnau, Pardo, Leonardo

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Direct determination of the chemical composition of acetylcholinesterase phosphonylation products utilizing electrospray-ionization mass spectrometry by Barak, Ruth, Ordentlich, Arie, Barak, Dov, Fischer, Meir, Benschop, Hendrik P, De Jong, Leo P.A, Segall, Yoffi, Velan, Baruch, Shafferman, Avigdor

“…While non-reactivability of cholinesterases from their phosphyl conjugates (aging) is attributed to an unimolecular process involving loss of alkyl group from…”
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Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions by Barak, Dov, Ordentlich, Arie, Stein, Dana, Yu, Qian-Sheng, Greig, Nigel H, Shafferman, Avigdor

“…The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several…”
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Evaluation of Homology Modeling of G-Protein-Coupled Receptors in Light of the A 2A Adenosine Receptor Crystallographic Structure by Ivanov, Andrei A., Barak, Dov, Jacobson, Kenneth A.

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Structural Determinants of A3 Adenosine Receptor Activation:  Nucleoside Ligands at the Agonist/Antagonist Boundary by Gao, Zhan-Guo, Kim, Soo-Kyung, Biadatti, Thibaud, Chen, Wangzhong, Lee, Kyeong, Barak, Dov, Kim, Seong Gon, Johnson, Carl R, Jacobson, Kenneth A

“…Mutagenesis of the human A3 adenosine receptor (AR) suggested that certain amino acid residues contributed differently to ligand binding and activation…”
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Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary by Gao, Zhan-Guo, Kim, Soo-Kyung, Biadatti, Thibaud, Chen, Wangzhong, Lee, Kyeong, Barak, Dov, Kim, Seong Gon, Johnson, Carl R, Jacobson, Kenneth A

“…Mutagenesis of the human A(3) adenosine receptor (AR) suggested that certain amino acid residues contributed differently to ligand binding and activation…”
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Function-specific blockage of M1 and M3 muscarinic acetylcholine receptors by VX and echothiophate by PITTEL, Zipora, BARAK, Dov, SEGALL, Yoffi

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Flexibility versus “rigidity” of the functional architecture of AChE active center by Shafferman, Avigdor, Barak, Dov, Stein, Dana, Kronman, Chanoch, Velan, Baruch, Greig, Nigel H., Ordentlich, Arie

“…Functional architecture of the AChE active center appears to be characterized by both structural “rigidity”, necessary to stabilize the catalytic triad as well…”
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Efficacy and Safety of Intravenous Immunoglobulin in Patients with Metastatic Melanoma by SCHACHTER, JACOB, KATZ, URIEL, MAHRER, ARIE, BARAK, DOV, DAVID, LIAT ZIEGEL BEN, NUSBACHER, JACOB, SHOENFELD, YEHUDA

“…:  We have previously reported studies performed both in vitro and in laboratory animals, as well as a case study in humans, suggesting that intravenous…”
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