Assessment of anticancer, antimicrobial, antidiabetic, anti-obesity and antioxidant activity of Ocimum Basilicum seeds essential oil from Palestine

Many modern pharmaceutical researchers continue to focus on the discovery and evaluation of natural compounds for possible therapies for obesity, diabetes, infections, cancer, and oxidative stress. Extraction of Ocimum basilicum seed essential oil and evaluation of its antioxidant, anti-obesity, ant...

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Published in:	BMC complementary and alternative medicine Vol. 23; no. 1; p. 221
Main Authors:	Eid, Ahmad M, Jaradat, Nidal, Shraim, Naser, Hawash, Mohammed, Issa, Linda, Shakhsher, Mohammad, Nawahda, Nour, Hanbali, Ali, Barahmeh, Noor, Taha, Basil, Mousa, Ahmed
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 04-07-2023 BioMed Central BMC
Subjects:	Acarbose Anti-Bacterial Agents - pharmacology Anti-diabetic Anti-Infective Agents - pharmacology Anti-obesity Antibacterial agents Antibiotics Anticancer Anticancer properties Antidiabetics Antimicrobial Antimicrobial agents Antioxidant Antioxidants Antioxidants - pharmacology Antitumor activity Bacteria Cancer Cardiovascular disease Care and treatment Comparative analysis Cytotoxicity Diabetes Diabetes mellitus Diabetes therapy Doxorubicin Drug resistance E coli Enzymes Escherichia coli Essential oils Fungicides Health aspects Herbal medicine Herbs Hypoglycemic Agents - pharmacology Infection Klebsiella Low income groups Medical research Obesity Ocimum basilicum Oils & fats Oils, Volatile - pharmacology Oxidative stress Seeds Vitamin E Palestinian Territories United States > US Germany Antimicrobial Anti-diabetic Anti-obesity Anticancer Antioxidant Ocimum basilicum
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Summary:	Many modern pharmaceutical researchers continue to focus on the discovery and evaluation of natural compounds for possible therapies for obesity, diabetes, infections, cancer, and oxidative stress. Extraction of Ocimum basilicum seed essential oil and evaluation of its antioxidant, anti-obesity, antidiabetic, antibacterial, and cytotoxic activities were the goals of the current study. O. basilicum seed essential oil was extracted and evaluated for its anticancer, antimicrobial, antioxidant, anti-obesity, and anti-diabetic properties utilizing standard biomedical assays. O. basilicum seed essential oil showed good anticancer activity against Hep3B (IC 56.23 ± 1.32 µg/ml) and MCF-7 (80.35 ± 1.17 µg/ml) when compared with the positive control, Doxorubicin. In addition, the essential oil showed potent antibacterial (against Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa) and antifungal (against Candida albicans) activities. Moreover, as for the anti-amylase test, IC was 74.13 ± 1.1 µg/ml, a potent effect compared with the IC of acarbose, which was 28.10 ± 0.7 µg/ml. On the other hand, for the anti-lipase test, the IC was 112.20 ± 0.7 µg/ml a moderate effect compared with the IC of orlistat, which was 12.30 ± 0.8 µg/ml. Finally, the oil had a potent antioxidant effect with an IC of 23.44 ± 0.9 µg/ml compared with trolox (IC was 2.7 ± 0.5 µg/ml). This study has provided initial data that supports the importance of O. basilcum essential oil in traditional medicine. The extracted oil not only exhibited significant anticancer, antimicrobial, and antioxidant properties but also antidiabetic and anti-obesity effects, which provided a foundation for future research.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2662-7671 2662-7671 1472-6882
DOI:	10.1186/s12906-023-04058-w