Association of Interleukin‐1 Receptor Antagonist Gene Polymorphisms With Generalized Aggressive Periodontitis in an Iranian Population

Association of Interleukin‐1 Receptor Antagonist Gene Polymorphisms With Generalized Aggressive Periodontitis in an Iranian Population

Background: Periodontitis is a multifactorial disease that occurs in the presence of bacteria, environmental factors, and genetic predispositions. It is suggested that polymorphisms in the interleukin‐1 (IL1) receptor antagonist gene have an important role in the susceptibility of the host to period...

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Bibliographic Details
Published in:Journal of periodontology (1970) Vol. 81; no. 9; pp. 1342 - 1346
Main Authors: Baradaran‐Rahimi, Hesam, Radvar, Mehrdad, Arab, Hamid R., Tavakol‐Afshari, Jalil, Ebadian, Ahmad R.
Format: Journal Article
Language:English
Published: Chicago, IL American Academy of Periodontology 01-09-2010
Subjects:
Adult
Aggressive periodontitis
Aggressive Periodontitis - genetics
Alleles
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Chi-Square Distribution
Dentistry
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Female
Gene Frequency
Genetic Markers
Genetic Predisposition to Disease
Genotype
Humans
Interleukin 1 Receptor Antagonist Protein - genetics
interleukin‐1 receptor antagonist protein
Iran
Male
Medical sciences
Minisatellite Repeats
Non tumoral diseases
Otorhinolaryngology. Stomatology
Polymerase Chain Reaction
Polymorphism, Genetic
Young Adult
Iran
Stomatology
polymorphism, genetic
Dentistry
Generalized
Protein
Aggressive periodontitis
Polymerase chain reaction
Periodontal disease
Association
Gene
Periodontitis
interleukin-1 receptor antagonist protein
Interleukin 1
Genetics
Antagonist
Molecular biology
Polymorphism
Biological receptor
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Summary:Background: Periodontitis is a multifactorial disease that occurs in the presence of bacteria, environmental factors, and genetic predispositions. It is suggested that polymorphisms in the interleukin‐1 (IL1) receptor antagonist gene have an important role in the susceptibility of the host to periodontitis. This study investigates the association of a variable number of tandem repeat polymorphism in the IL1RN gene with generalized aggressive periodontitis (GAgP). Methods: Sixty‐six subjects with GAgP and 56 periodontally healthy subjects took part in the study. All subjects were of Iranian Khorasanian (north‐east province of Iran) descent. Subjects were identified through clinical examinations and radiographs at the Mashad Dental School and Dental Research Center. DNA was extracted from peripheral blood cells, and different genotypes were detected using polymerase chain reaction amplification and fragment‐size analysis. Data were analyzed using the χ2 test. Results: The frequencies of the IL1RN genotype A1A2 (χ2 test; P = 0.001) and allele A2 (χ2 test; P = 0.006) were found to be significantly increased in patients with GAgP compared to normal subjects. Conclusion: These findings suggest that the polymorphic IL1RN gene is a risk determinant for generalized aggressive periodontitis in the Iranian Khorasanian population.
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content type line 23
ISSN:0022-3492
1943-3670
DOI:10.1902/jop.2010.100073