Search Results - "Barabino, L"

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid–liquid phase separation by Reber, Stefan, Jutzi, Daniel, Lindsay, Helen, Devoy, Anny, Mechtersheimer, Jonas, Levone, Brunno Rocha, Domanski, Michal, Bentmann, Eva, Dormann, Dorothee, Mühlemann, Oliver, Barabino, Silvia M L, Ruepp, Marc-David

“…Abstract Liquid–liquid phase separation (LLPS) of proteins and RNAs has emerged as the driving force underlying the formation of membrane-less organelles. Such…”
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Clinical course and features of persistent polyclonal B-cell lymphocytosis with BCL-6 amplification during pregnancy by Galitzia, A, Murru, R, Caocci, G, Barabino, L, Azzena, A, Licheri, V M, Greco, M, La Nasa, G

“…Persistent polyclonal B-cell lymphocytosis is a rare nonmalignant disorder characterized by mild persistent lymphocyte proliferation with possible evolution to…”
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Three is better than two: humoral response in allogeneic HSCT after the third BNT162b2 SARS-CoV-2 mRNA vaccine by Barabino, L, Galitzia, A, Murru, R, Caocci, G, Greco, M, Targhetta, C, Angioni, G, Vacca, A, Piras, E, Frau, V, Mulas, O, La Nasa, G

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Chronic graft vs. host disease and hypogammaglobulinemia predict a lower immunological response to the BNT162b2 mRNA COVID-19 vaccine after allogeneic hematopoietic stem cell transplantation by Barabino, L, Galitzia, A, Murru, R, Caocci, G, Targhetta, C, Greco, M, Angioni, G, Mulas, O, Vacca, A, Piras, E, Frau, V, Costa, A, La Nasa, G

“…Due to the high mortality rate of COVID-19, the assessment of BNT162b2 SARS-CoV-2 mRNA vaccine (Pfizer-BioNTech) efficacy in allogeneic hematopoietic stem cell…”
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Paraquat modulates alternative pre-mRNA splicing by modifying the intracellular distribution of SRPK2 by Vivarelli, Silvia, Lenzken, Silvia C, Ruepp, Marc-David, Ranzini, Francesco, Maffioletti, Andrea, Alvarez, Reinaldo, Mühlemann, Oliver, Barabino, Silvia M L

“…Paraquat (PQ) is a neurotoxic herbicide that induces superoxide formation. Although it is known that its toxic properties are linked to ROS production, the…”
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RNA Splicing: A New Player in the DNA Damage Response by Lenzken, Silvia C., Barabino, Silvia M. L., Loffreda, Alessia

“…It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations. However, the molecular…”
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RNA-Binding Proteins in the Regulation of miRNA Activity: A Focus on Neuronal Functions by Loffreda, Alessia, Rigamonti, Aurora, Barabino, Silvia M L, Lenzken, Silvia C

“…Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are…”
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P660: SEROLOGIC RESPONSE TO THE SECOND AND THIRD DOSE OF THE SARS‐COV‐2 VACCINE IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA: RESULTS OF A PROSPECTIVE, CENTRALIZED, MULTICENTER STUDY by Mauro, F. R., Giannarelli, D., Galluzzo, C., Visentin, A., Frustaci, A. M., Sportoletti, P., Vitale, C., Reda, G., Gentile, M., Levato, L., Murru, R., Armiento, D., Ielo, C., Maglione, R., Crisanti, E., Cipiciani, A., Mattiello, V., Gianfelici, V., Barabino, L., Amici, R., Coscia, M., Tedeschi, A., Trentin, L., Baroncelli, S.

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FUS-dependent liquid-liquid phase separation is important for DNA repair initiation by Levone, Brunno R, Lenzken, Silvia C, Antonaci, Marco, Maiser, Andreas, Rapp, Alexander, Conte, Francesca, Reber, Stefan, Mechtersheimer, Jonas, Ronchi, Antonella E, Mühlemann, Oliver, Leonhardt, Heinrich, Cardoso, M Cristina, Ruepp, Marc-David, Barabino, Silvia M L

“…RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA…”
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SOX6 blocks the proliferation of BCR-ABL1+ and JAK2V617F+ leukemic cells by Barbarani, Gloria, Fugazza, Cristina, Barabino, Silvia M. L., Ronchi, Antonella E.

“…SOX6 is a HMG-box transcription factor expressed in a wide range of tissues. Recent data show that SOX6 expression is altered in different cancers, in the…”
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Proteomics Strategies to Identify SUMO Targets and Acceptor Sites: A Survey of RNA-Binding Proteins SUMOylation by Filosa, Giuseppe, Barabino, Silvia M. L., Bachi, Angela

“…SUMOylation is a protein posttranslational modification that participates in the regulation of numerous biological processes within the cells. Small…”
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Distinct Sequence Motifs within the 68-kDa Subunit of Cleavage Factor Im Mediate RNA Binding, Protein-Protein Interactions, and Subcellular Localization by Dettwiler, Sabine, Aringhieri, Chiara, Cardinale, Stefano, Keller, Walter, Barabino, Silvia M L

“…Cleavage factor I m (CF I m ) is required for the first step in pre-mRNA 3′-end processing and can be reconstituted in vitro from its heterologously…”
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Neuronal RNA-binding proteins in health and disease by Lenzken, Silvia Carolina, Achsel, Tilmann, Carrì, Maria Teresa, Barabino, Silvia M.L.

“…In mammalian cells in general and in neurons in particular, mRNA maturation, translation, and degradation are highly complex and dynamic processes. RNA‐binding…”
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Subnuclear localization and dynamics of the Pre-mRNA 3' end processing factor mammalian cleavage factor I 68-kDa subunit by Cardinale, Stefano, Cisterna, Barbara, Bonetti, Paolo, Aringhieri, Chiara, Biggiogera, Marco, Barabino, Silvia M L

“…Mammalian cleavage factor I (CF Im) is an essential factor that is required for the first step in pre-mRNA 3' end processing. Here, we characterize CF Im68…”
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68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs by Ruepp, Marc-David, Vivarelli, Silvia, Pillai, Ramesh S, Kleinschmidt, Nicole, Azzouz, Teldja N, Barabino, Silvia M.L, Schümperli, Daniel

“…Metazoan replication-dependent histone pre-mRNAs undergo a unique 3'-cleavage reaction which does not result in mRNA polyadenylation. Although the cleavage…”
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Mutant SOD1 and mitochondrial damage alter expression and splicing of genes controlling neuritogenesis in models of neurodegeneration by Lenzken, Silvia C, Romeo, Valentina, Zolezzi, Francesca, Cordero, Francesca, Lamorte, Giuseppe, Bonanno, Davide, Biancolini, Donatella, Cozzolino, Mauro, Pesaresi, Maria Grazia, Maracchioni, Alessia, Sanges, Remo, Achsel, Tilmann, Carrì, Maria Teresa, Calogero, Raffaele A, Barabino, Silvia M.L

“…Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders including Parkinson, Alzheimer, and Amyotrophic…”
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miR-129-5p: A key factor and therapeutic target in amyotrophic lateral sclerosis by Loffreda, Alessia, Nizzardo, Monica, Arosio, Alessandro, Ruepp, Marc-David, Calogero, Raffaele A., Volinia, Stefano, Galasso, Marco, Bendotti, Caterina, Ferrarese, Carlo, Lunetta, Christian, Rizzuti, Mafalda, Ronchi, Antonella E., Mühlemann, Oliver, Tremolizzo, Lucio, Corti, Stefania, Barabino, Silvia M.L.

“…•miR-129-5p is increased in different models of SOD1-linked ALS and in peripheral blood cells of sporadic ALS patients.•miR-129-5p upregulation causes the…”
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Transcription Factors, R-Loops and Deubiquitinating Enzymes: Emerging Targets in Myelodysplastic Syndromes and Acute Myeloid Leukemia by Barabino, Silvia M. L., Citterio, Elisabetta, Ronchi, Antonella Ellena

“…Myeloid neoplasms encompass a very heterogeneous family of diseases characterized by the failure of the molecular mechanisms that ensure a balanced equilibrium…”
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Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants by Reber, Stefan, Stettler, Jolanda, Filosa, Giuseppe, Colombo, Martino, Jutzi, Daniel, Lenzken, Silvia C, Schweingruber, Christoph, Bruggmann, Rémy, Bachi, Angela, Barabino, Silvia ML, Mühlemann, Oliver, Ruepp, Marc-David

“…Fused in sarcoma (FUS) is a ubiquitously expressed RNA‐binding protein proposed to function in various RNA metabolic pathways, including transcription…”
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Oxidative stress controls the choice of alternative last exons via a Brahma-BRCA1-CstF pathway by Fontana, Gabriele A, Rigamonti, Aurora, Lenzken, Silvia C, Filosa, Giuseppe, Alvarez, Reinaldo, Calogero, Raffaele, Bianchi, Marco E, Barabino, Silvia M L

“…Alternative splicing of terminal exons increases transcript and protein diversity. How physiological and pathological stimuli regulate the choice between…”
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