Search Results - "Bara, Anne"
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Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut
Published in Development (Cambridge) (01-12-2022)“…There are fundamental differences in how neonatal and adult intestines absorb nutrients. In adults, macromolecules are broken down into simpler molecular…”
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Journal Article -
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FMR1 loss in a human stem cell model reveals early changes to intrinsic membrane excitability
Published in Developmental biology (01-12-2020)“…Fragile X mental retardation 1 (FMR1) encodes the RNA binding protein FMRP. Loss of FMRP drives Fragile X syndrome (FXS), the leading inherited cause of…”
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Journal Article -
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A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease
Published in Stem cell reports (10-10-2017)“…Scaling of CRISPR-Cas9 technology in human pluripotent stem cells (hPSCs) represents an important step for modeling complex disease and developing drug screens…”
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Generation of a TLE3 heterozygous knockout human embryonic stem cell line using CRISPR-Cas9
Published in Stem cell research (01-09-2016)“…Here, we generated a monoallelic mutation in the TLE3 (Transducin Like Enhancer of Split 3) gene using CRISPR-Cas9 editing in the human embryonic stem cell…”
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Journal Article -
5
Generation of a TLE1 homozygous knockout human embryonic stem cell line using CRISPR-Cas9
Published in Stem cell research (01-09-2016)“…Here, we generated a biallelic mutation in the TLE1 (Transducin Like Enhancer of Split 1) gene using CRISPR-Cas9 editing in the human embryonic stem cell…”
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Journal Article -
6
Host cell autophagy promotes BK virus infection
Published in Virology (New York, N.Y.) (01-05-2014)“…Abstract Autophagy is important for a variety for virus life cycles. We sought to determine the role of autophagy in human BK polyomavirus (BKPyV) infection…”
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Journal Article -
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The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia
Published in Nature communications (27-06-2022)“…It is unclear how the 22q11.2 deletion predisposes to psychiatric disease. To study this, we generated induced pluripotent stem cells from deletion carriers…”
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Journal Article -
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Maf Family Proteins in the Intestinal Epithelium
Published 01-01-2022“…There are fundamental differences in the way that neonatal and adult intestines absorb nutrients. In adults, macromolecules are efficiently broken down into…”
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Dissertation -
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Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity
Published in Developmental cell (26-03-2018)“…We show that the loss or gain of transcription factor programs that govern embryonic cell-fate specification is associated with a form of tumor plasticity…”
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Journal Article